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(Theoretical biology medical modelling[TA])
544 results
  • A highly pathogenic simian/human immunodeficiency virus effectively produces infectious virions compared with a less pathogenic virus in cell culture. [Journal Article]
  • TBTheor Biol Med Model 2017 Apr 21; 14(1):9
  • Iwanami S, Kakizoe Y, … Iwami S
  • CONCLUSIONS: We quantified virological indices including virus burst sizes and basic reproduction number of both SHIV-KS661 and -#64. Comparing the burst size of total and infectious viruses (viral RNA copies and TCID50, respectively), we found that there was a statistically significant difference between the infectious virus burst size of SHIV-KS661 and -#64, while there was no significant difference between the total virus burst size. Furthermore, our analyses showed that the fraction of infectious virus among the produced SHIV-KS661 viruses, which is defined as the infectious viral load (TCID50/ml) divided by the total viral load (RNA copies/ml), is more than 10-fold higher than that of SHIV-#64 during overall infection (i.e., for 9 days). Taken together, we conclude that the highly pathogenic SHIV produces infectious virions more effectively than the less pathogenic SHIV in cell culture.
  • An outbreak vector-host epidemic model with spatial structure: the 2015-2016 Zika outbreak in Rio De Janeiro. [Journal Article]
  • TBTheor Biol Med Model 2017 Mar 27; 14(1):7
  • Fitzgibbon WE, Morgan JJ, Webb GF
  • CONCLUSIONS: The results for the model simulations of the 2015-2016 Zika seasonal outbreak in Rio de Janeiro Municipality indicate that the spatial distribution and final size of the epidemic at the end of the season are strongly dependent on the location and magnitude of local outbreaks at the beginning of the season. The application of the model to the Rio de Janeiro Municipality Zika 2015-2016 outbreak is limited by incompleteness of the epidemic data and by uncertainties in the parametric assumptions of the model.
  • Modeling multi-mutation and drug resistance: analysis of some case studies. [Journal Article]
  • TBTheor Biol Med Model 2017 Mar 21; 14(1):6
  • Feizabadi MS
  • CONCLUSIONS: In the present study, the evolution of the cells in a conjoint setting, when the system expresses both intrinsic and induced resistance, is mathematically modeled. Followed by a set of computer simulations, the different growing patterns that can be created based on choices of therapy were examined. The model can still be improved by considering other factors including, but not limited to, the nature of the cancer growth, the level of toxicity that the body can tolerate, or the strength of the patient's immune system.
  • The role of mobility and health disparities on the transmission dynamics of Tuberculosis. [Journal Article]
  • TBTheor Biol Med Model 2017 Jan 28; 14(1):3
  • Moreno V, Espinoza B, … Castillo-Chavez C
  • CONCLUSIONS: The study highlights that allowing infected individuals to move from high to low TB prevalence areas (for example via the sharing of treatment and isolation facilities) may lead to a reduction in the total TB prevalence in the overall population. The higher the population size heterogeneity between distinct risk patches, the larger the benefit (low overall prevalence) under the same "traveling" patterns. Policies need to account for population specific factors (such as risks that are inherent with high levels of migration, local and regional mobility patterns, and first time infection rates) in order to be long lasting, effective and results in low number of drug resistant cases.
  • Thermodynamic considerations in renal separation processes. [Journal Article]
  • TBTheor Biol Med Model 2017 Jan 26; 14(1):2
  • Louw RH, Rubin DM, … Hildebrandt D
  • CONCLUSIONS: A comparison of these thermodynamic results with physiological reference points, elucidates how various factors affect the energy cost of the process. Surprisingly little energy is required to produce human urine, seeing that double the amount of work can theoretically be done with all the energy provided through pressure drop of blood flow through the kidneys, while the metabolic energy consumption of the kidneys could possibly drive almost one hundred times more separation work. Nonetheless, the model's outputs, which are summarised graphically, show the separation work's nuances, which can be further analysed in the context of more empirical evidence.
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