Serum zinc, copper and magnesium were studied in patients with sickle cell disease in the steady state. There was significantly lower serum zinc concentration (P < 0.01) and significantly higher serum copper and magnesium in haemoglobin S patients compared with controls (HbA). In haemoglobin SC patients, there was a significant reduction in serum zinc (P < 0.01) but no significant difference in serum copper and magnesium concentrations compared with the controls. There was no significant difference in serum zinc concentration between the HbS and HbS + C patients. However there were significantly higher serum copper and magnesium in HbS than HbS + C patients (P < 0.01) The level of serum zinc has no correlation with the steady state Haematocrit or severity index score in HbS and HbS + C patients.