The authors present the case of a 47-year-old female who presents with bilateral Dupuytren's disease of the wrist. To date, three English language papers reporting on the occurrence of Dupuytren's disease at the wrist have been presented. These reports represent cases in males with unilateral involvement of their wrists where there has been primary Dupuytren's disease of the palm apparently spreading to the wrist in continuity. Our case demonstrates isolated bilateral Dupuytren's disease of the wrist in a female. The authors feel that this clinical presentation is rare and that consideration should be given to the diagnosis of Dupuytren's disease when there is a painful lesion of the soft tissues adjacent to the wrist. The presence of bilateral lesions at the wrist should further heighten the suspicion of Dupuytren's disease even in the absence of associated disease in the palm or fingers. A discussion of the previous reports is included.