[The preventive effect of allopurinol spray on stomatitis induced by anti-cancer drugs].
Gan To Kagaku Ryoho. 2002 Apr; 29(4):563-7.GT

Abstract

The present study was conducted to evaluate the effect of allopurinol spray on stomatitis induced by chemotherapy for esophageal cancer. The chemotherapeutics used consisted of 5-FU + CDDP (FC) given to 40 patients and 5-FU + ND (FN) given to 9 patients. Allopurinol solution for spray was prepared using a gelatin agent as base. The allopurinol spray was used 3-5 times daily before and after chemotherapy. The Japan Society for Cancer Therapy's criteria for stomatitis were used. With FN-therapy, no stomatitis was observed. With FC-therapy, 9 of 40 patients developed stomatitis of grade 1 (8 patients) or grade 2 (1). The incidence of stomatitis was 18.4% with all therapies and 22.5% with FC-therapy. The average graded toxicity was 0.20 for all therapies and 0.25 for FC-therapy. These results suggest that allopurinol spray is markedly effective for the prevention of stomatitis induced by chemotherapy. In addition, allopurinol spray is portable and convenient, and resulted in less nausea or vomiting than mouthwash.

Authors+Show Affiliations

Ito A
Dept. of Pharmacy, Tokyo Women's Medical University.
Hanawa T
No affiliation info available
Fujii E
No affiliation info available

MeSH

AerosolsAllopurinolAntineoplastic Combined Chemotherapy ProtocolsCisplatinEsophageal NeoplasmsFluorouracilHumansStomatitis

Pub Type(s)

Clinical Trial
English Abstract
Journal Article

Language

jpn

PubMed ID

11977540