Atherosclerosis is a generalized vascular disease. There are methods to investigate the development of atherosclerosis. Doppler ultrasonography is a noninvasive and safe method. By this method we can see and measure the first stage of atherosclerosis development--thickening of intima-media complex. Measuring intima-media thickness of common carotid artery may be used as an indicator of generalized atherosclerosis. Intima-media thickness is also used to study progression of atherosclerosis and its possible regression during therapy.