The interaction between FOXO and SIRT1: tipping the balance towards survival.
Trends Cell Biol. 2004 Aug; 14(8):408-12.TC

Abstract

When overexpressed, the NAD-dependent protein deacetylase Sir2 extends the lifespan of both budding yeast and the nematode worm Caenorhabditis elegans. In the worm, this extension of lifespan requires the FOXO transcription factor daf-16. Three recent articles focusing on mammalian homologues of Sir2 and FOXO have highlighted the mechanisms that generate this genetic interaction. Mammalian SIRT1 deacetylates FOXO3 and/or FOXO4, thus attenuating FOXO-induced apoptosis and potentiating FOXO-induced cell-cycle arrest. SIRT1 might increase longevity by shifting FOXO dependent responses away from cell death and towards cell survival.

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Authors+Show Affiliations

Giannakou ME
Department of Biology, University College London, London WC1E 6BT, UK.
Partridge L
No affiliation info available

MeSH

AnimalsCell Cycle ProteinsCell SurvivalDrosophila ProteinsForkhead Box Protein O3Forkhead Transcription FactorsHistone DeacetylasesHumansSirtuin 1SirtuinsTranscription Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15308206