BINOL catalyzed enantioselective addition of titanium phenylacetylide to aromatic ketones.

Chem Commun (Camb). 2004 Nov 07CC

An enantioselective addition of titanium phenylacetylide to ketones, promoted by BINOL, is described; this new enantioselective protocol gives high enantiomeric excess (up to 90% ee) with aromatic ketones using a simple procedure without pyrophoric or expensive reagents.