Inter-instrumental variation of skin capacitance measured with the Corneometer.Skin Res Technol. 2005 May; 11(2):107-9.SR
BACKGROUND/PURPOSE
Measurement of skin surface and stratum corneum (SC) hydration during clinical and/or experimental trials needs devices with acceptable reproducibility and sensitivity under conditions ranging from increased and normal to low hydration. A previous study comparing Corneometer instruments (European group for Efficacy Measurement of Cosmetics and Other products--EEMCO) used for measurement of electrical capacitance of skin indicated a major difference among Corneometer instruments. The aim of this study was to assess three inter-instrumental similar Corneometer instruments (two pieces of CM820 and one CM810) in normal skin. We named them CM-A(CM820), CM-B(CM820), and CM-C(CM810).
METHODS
The hydration state of SC measured as electrical capacitance of six body sites were measured in 53 subjects with three Corneometer instruments.
RESULT
We found that the Corneometer instruments displayed close capacitance levels. When one Corneometer was plotted against another the regression line indicated a good correlation among instruments albeit a major and random disagreement could appear in individual sites as an exception.
CONCLUSION
Three Corneometer instruments evaluated in this study gave close measurements and correlated well. Nevertheless, pretest validation of instruments should be undertaken in multicenter studies where capacitance data are compared or pooled, and concordance among instruments should be documented prior to study.