[Sex differences in brain stem auditory evoked potentials and P300 examination in patients with mild cognitive impairment and Alzheimer's disease].
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2005 Mar; 34(2):172-6.ZD

Abstract

OBJECTIVE

To compare the sex differences on brain stem auditory evoked potentials (BAEP) and P300 in the elderly patients with mild cognitive impairment (MCI) and the patients with Alzheimer's disease (AD).

METHODS

Thirty-eight elderly patients with MCI, 26 cases of AD and 20 health controls (HC) were examined with BAEP, P300 . Sex difference of the variables was compared inter-and intra-groups.

RESULTS

Significant sex differences of BAEP were found in the latency period wave III, V of left side in the MCI group (P <0.01), in the latency period wave IV, V of left side in HC group (P<0.01), and no such differences were found in AD group. The females had longer latency period in P300 measurement than males in MCI group (P <0.01), but there were no significant differences within AD or HC groups. The males showed significant differences in wave I, II in left side between the MCI and AD groups. The males also showed significant difference in wave I, III approximate, equals V in left side, wave IV in right side between AD and HC groups, and so did the females in wave I approximate, equals V in both sides. The males had significant difference in the left wave III, IV and right wave I, IV, V between MCI and HC groups, and so did the females in right side wave I, II, V. In P300, longer latency waves were found in AD group than in MCI group. Both sexes showed significant differences in the latency of Fz, Cz, Pz between AD and HC groups, but no significant differences were found in the latency of Fz, Cz, Pz in the females between the MCI and HC groups.

CONCLUSION

Sex differences were found in the examination of both BAEP and P300 in MCI group, but not in AD group. The people of same sex have different expression of BAEP and P300 among MCI, AD and HC groups, suggesting the sex difference should be considered in the differential diagnosis.

Authors+Show Affiliations

Chen W
Department of Psychology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China. cc0731@hzcnc.com
Wang JQ
No affiliation info available
Zhang LJ
No affiliation info available

MeSH

AgedAged, 80 and overAlzheimer DiseaseCognition DisordersDiagnosis, DifferentialEvent-Related Potentials, P300Evoked Potentials, Auditory, Brain StemFemaleHumansMaleMiddle AgedSex Factors

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

15812894