The large first periplasmic loop of SecD and SecF plays an important role in SecDF functioning.
A remarkable feature of proteins of the SecD and SecF family involved in protein translocation is that they possess a very large first periplasmic domain. Here we report that this large first periplasmic domain is not required for the SecD-SecF interaction but that it is important for catalyzing protein translocation.
Bacterial ProteinsCytoplasmEscherichia coliEscherichia coli ProteinsGene DeletionMembrane ProteinsMembrane Transport ProteinsMutagenesisProtein Structure, Tertiary
Research Support, Non-U.S. Gov't