The additive effects of minoxidil and retinol on human hair growth in vitro.
Biol Pharm Bull. 2007 Jan; 30(1):21-6.BP

Abstract

Minoxidil enhances hair growth by prolonging the anagen phase and induces new hair growth in androgenetic alopecia (AGA), whereas retinol significantly improves scalp skin condition and promotes hair growth. We investigated the combined effects of minoxidil and retinol on human hair growth in vitro and on cultured human dermal papilla cells (DPCs) and epidermal keratinocytes (HaCaT). The combination of minoxidil and retinol additively promoted hair growth in hair follicle organ cultures. In addition, minoxidil plus retinol more effectively elevated phosphorylated Erk, phosphorylated Akt levels, and the Bcl-2/Bax ratio than minoxidil alone in DPCs and HaCaT. We found that the significant hair shaft elongation demonstrated after minoxidil plus retinol treatment would depend on the dual kinetics associated with the activations of Erk- and Akt-dependent pathways and the prevention of apoptosis by increasing the Bcl-2/Bax ratio.

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Authors+Show Affiliations

Yoo HG
Department of Dermatology, Seoul National University College of Medicine, Korea.
Chang IY
No affiliation info available
Pyo HK
No affiliation info available
Kang YJ
No affiliation info available
Lee SH
No affiliation info available
Kwon OS
No affiliation info available
Cho KH
No affiliation info available
Eun HC
No affiliation info available
Kim KH
No affiliation info available

MeSH

AdultAlopeciaApoptosisCell LineCell ProliferationDose-Response Relationship, DrugDrug Therapy, CombinationExtracellular Signal-Regulated MAP KinasesHairHair FollicleHumansKeratinocytesMaleMinoxidilOrgan Culture TechniquesPhosphorylationProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-bcl-2SkinVitamin AVitaminsbcl-2-Associated X Protein

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17202653