Does diagnosis of metabolic syndrome predict the likelihood of peripheral arterial disease as defined by a low ankle-brachial index?
Eur J Cardiovasc Prev Rehabil. 2008 Dec; 15(6):693-7.EJ

Abstract

BACKGROUND

There is limited information about whether a diagnosis of metabolic syndrome (MS) predicts peripheral arterial disease independently of diabetes. This study assessed whether MS adds prognostic information beyond that relating to diabetes in the identification of a low ankle-brachial index (ABI).

DESIGN

Cross-sectional population-based study of people aged 50-75 years.

METHODS

Eight hundred and fifty-eight participants were randomly selected. The likelihood of low ABI (<0.90) was calculated according to MS status before and after excluding diabetes. The National Cholesterol Education Panel and the International Diabetes Federation (IDF) definitions of MS were used.

RESULTS

The prevalence of National Cholesterol Education Panel-defined and IDF-defined MS, and low ABI was 57.8, 61.1 and 7.5%, respectively. When there were participants with three or more criteria for MS, participants with only three criteria, and participants with four or five criteria were compared with participants without MS, the odds ratio for low ABI was 1.89 (95% confidence interval, 1.08-3.30), 1.34 (0.70-2.60) and 2.70 (1.45-5.03), respectively. The association of MS and low ABI lost statistical significance after excluding diabetes. No difference was observed using the IDF definition of MS.

CONCLUSION

Screening of participants with MS does not improve the identification of abnormal ABI provided by diabetes.

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Authors+Show Affiliations

López-Suárez A
Internal Medicine Department, Virgen del Camino Hospital, Sanlúcar de Barrameda Cádiz, Spain. a.lopez.ssl@gmail.com
Beltrán-Robles M
No affiliation info available
Elvira-González J
No affiliation info available
Alwakil M
No affiliation info available
Bascuñana-Quirell A
No affiliation info available
Rosal-Obrador J
No affiliation info available
Badani-Gutiérrez H
No affiliation info available
Oliver-Pece M
No affiliation info available
Pons-Raga A
No affiliation info available
Ruiz-DeCastroviejo J
No affiliation info available
Cañas-Hormigo F
No affiliation info available
Benítez-Rodríguez E
No affiliation info available

MeSH

AgedAnkleBlood PressureBrachial ArteryCross-Sectional StudiesDiabetes MellitusFemaleHumansLikelihood FunctionsMaleMass ScreeningMetabolic SyndromeMiddle AgedOdds RatioPeripheral Vascular DiseasesPredictive Value of TestsPrevalenceProspective StudiesRisk AssessmentRisk FactorsTime Factors

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18756176