Automated assessment of whole-body adipose tissue depots from continuously moving bed MRI: a feasibility study.
J Magn Reson Imaging. 2009 Jul; 30(1):185-93.JM

Abstract

PURPOSE

To present an automated algorithm for segmentation of visceral, subcutaneous, and total volumes of adipose tissue depots (VAT, SAT, TAT) from whole-body MRI data sets and to investigate the VAT segmentation accuracy and the reproducibility of all depot assessments.

MATERIALS AND METHODS

Repeated measurements were performed on 24 volunteer subjects using a 1.5 Tesla clinical MRI scanner and a three-dimensional (3D) multi-gradient-echo sequence (resolution: 2.1 x 2.1 x 8 mm(3), acquisition time: 5 min 15 s). Fat and water images were reconstructed, and fully automated segmentation was performed. Manual segmentation of the VAT reference was performed by an experienced operator.

RESULTS

Strong correlation (R = 0.999) was found between the automated and manual VAT assessments. The automated results underestimated VAT with 4.7 +/- 4.4%. The accuracy was 88 +/- 4.5% and 7.6 +/- 5.7% for true positive and false positive fractions, respectively. Coefficients of variation from the repeated measurements were: 2.32 % +/- 2.61%, 2.25% +/- 2.10%, and 1.01% +/- 0.74% for VAT, SAT, and TAT, respectively.

CONCLUSION

Automated and manual VAT results correlated strongly. The assessments of all depots were highly reproducible. The acquisition and postprocessing techniques presented are likely useful in obesity related studies.

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Authors+Show Affiliations

Kullberg J
Department of Radiology, Uppsala University, Uppsala, Sweden. joel.kullberg@radiol.uu.se
Johansson L
No affiliation info available
Ahlström H
No affiliation info available
Courivaud F
No affiliation info available
Koken P
No affiliation info available
Eggers H
No affiliation info available
Börnert P
No affiliation info available

MeSH

Adipose TissueAdultAlgorithmsBody Fat DistributionFeasibility StudiesFemaleHumansImaging, Three-DimensionalIntra-Abdominal FatMagnetic Resonance ImagingMaleMiddle AgedMotionReference ValuesReproducibility of ResultsSubcutaneous FatWhole Body ImagingYoung Adult

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19557740