SERS aptasensor from nanorod-nanoparticle junction for protein detection.
A multicomponent nanostructure comprising of gold nanorod-nanoparticle (AuNR-AuNP) composites was fabricated to detect thrombin at subnanomolar concentrations in diluted human blood serum. Simulation and experiments revealed that the strong electromagnetic coupling resonance at the nanorod-nanoparticle junction of these probes can be used to construct highly sensitive SERS aptasensors.
AnimalsAptamers, NucleotideBiosensing TechniquesCattleGoldHumansLimit of DetectionNanoparticlesNanostructuresNanotubesProtein BindingSerumSerum Albumin, BovineSpectrum Analysis, RamanThrombin
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.