To evaluate the potential of stratus optical coherence tomography (OCT) for detecting early glaucoma.
Fifty-two open-angle glaucoma patients with unilateral visual field loss detected by standard automatic perimetry were tested using stratus OCT and frequency doubling technology (FDT) N-30. Fifty-two perimetrically normal eyes were enrolled and divided into 2 groups: eyes with normal OCT results and eyes with abnormal OCT results. FDT parameters and scores were compared between the 2 groups. We evaluated the topographic relationship of the OCT-measured retinal nerve fiber layer (RNFL) defects with the FDT-measured visual field loss and glaucomatous optic neuropathy.
In eyes with abnormal OCT results, the percentage of eyes with abnormal FDT results was significantly higher (P<0.001); FDT mean deviation, pattern standard deviation, and scores were significantly worse than those with normal OCT results (P=0.005, P<0.001, P<0.001, respectively); and the OCT-measured RNFL defects showed good topographic agreement with the FDT-measured visual field loss and glaucomatous optic neuropathy.
RNFL defects detected by stratus OCT were associated with FDT visual field loss. Stratus OCT can detect early glaucoma sooner than standard automatic perimetry.