Environmental factors and Parkinson's disease: a case-control study in Belgrade, Serbia.
Int J Neurosci. 2010 May; 120(5):361-7.IJ

Abstract

A case-control study was performed in Belgrade in order to investigate the association between Parkinson's disease (PD) and some environmental factors. During the period 2001-2005, 110 new PD cases and 220 hospital controls were interviewed. Cases and controls were matched by sex, age (+/-2 years), and place of residence (urban/rural). According to multivariate conditional logistic regression analysis, PD was positively asssociated with exposure to insecticides (odds ratio (OR) 3.22, 95% confidence interval (95% CI) 1.32-7.87), dyes (OR 25.33; 95% CI, 2.89-222.0), and naphtha and its derivates (OR 9.53; 95% CI, 1.04-86.96), and with gardening (OR 5.51; 95% CI, 3.04-10.01), well water drinking (OR 2.62; 95% CI, 1.40-4.90), and spring water drinking (OR 2.19; 95% CI, 1.15-4.16). Negative association was found for service-sector working (OR 0.15; 95% CI, 0.04-0.59). The results obtained did not changed after adjustment for smoking. The findings of the present study support the role of environmental factors in the occurence of PD.

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Authors+Show Affiliations

Vlajinac HD
Institute of Epidemiology, School of Medicine, University of Belgrade, Visegradska 26, Belgrade, 11000 Serbia. kristiv@eunet.rs
Hristina VD
No affiliation info available
Sipetic SB
No affiliation info available
Maksimovic JM
No affiliation info available
Marinkovic JM
No affiliation info available
Dzoljic ED
No affiliation info available
Ratkov IS
No affiliation info available
Kostic VS
No affiliation info available

MeSH

AdultAgedAgricultureCase-Control StudiesEnvironmental ExposureFemaleHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisParkinson DiseasePesticidesRisk FactorsRural HealthSerbiaWater Supply

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20402575