This review article discusses important infectious illnesses, namely malaria, dengue, and chikungunya, in travelers returning from endemic areas. Malaria and dengue are two of the most common systemic illnesses reported in returning travelers. Because chikungunya is gaining importance, it is also briefly discussed. The clinical significance of these diseases is mainly due to the possibility of sudden deterioration with high mortality in clinically healthy looking patients. The key clinical features, their diagnosis, and treatment algorithms are discussed in detail to help in early diagnosis and appropriate clinical management of such travelers presenting in emergency departments.