Analysis of anti-Clostridium difficile activity of thuricin CD, vancomycin, metronidazole, ramoplanin, and actagardine, both singly and in paired combinations.
Antimicrob Agents Chemother. 2013 Jun; 57(6):2882-6.AA

Abstract

Due to the ongoing problem of recurrence of Clostridium difficile-associated diarrhea following antibiotic treatment, there is an urgent need for alternative treatment options. We assessed the MICs of five antimicrobials singly and in combinations against a range of C. difficile clinical isolates. Ramoplanin-actagardine combinations were particularly effective, with partial synergistic/additive effects observed against 61.5% of C. difficile strains tested.

Links

Publisher Full Text
ncbi.nlm.nih.gov
aac.asm.org
PMC Free PDF

Authors+Show Affiliations

Mathur H
Department of Microbiology, University College Cork, Cork, Ireland.
O'Connor PM
No affiliation info available
Hill C
No affiliation info available
Cotter PD
No affiliation info available
Ross RP
No affiliation info available

MeSH

Anti-Bacterial AgentsBacteriocinsClostridioides difficileDepsipeptidesDrug SynergismDrug Therapy, CombinationEnterocolitis, PseudomembranousHumansMetronidazoleMicrobial Sensitivity TestsPeptidesVancomycin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23571539