Long-chain n-3 polyunsaturated fatty acids intake and cardiovascular disease mortality risk in Japanese: a 24-year follow-up of NIPPON DATA80.
Abstract
BACKGROUND
Dietary intake of long-chain n-3 PUFA (LCn3FA) among Japanese is generally higher than that in Western populations. However, little is known whether an inverse association of LCn3FA with cardiovascular disease (CVD) risk exists in a population with higher LCn3FA intake.
OBJECTIVE
To investigate the association between LCn3FA intake and the long-term risk of CVDs in a Japanese general population.
METHODS
We followed-up a total of 9190 individuals (56.2% women, mean age 50.0 years) randomly selected from 300 areas across Japan and free from CVDs at baseline. Dietary LCn3FA intake was estimated using household weighed food records. Cox models were used to calculate multivariate-adjusted hazard ratios (HR) and confidence intervals (CI) according to sex specific quartiles of LCn3FA intake.
RESULTS
During 24-year follow-up (192,897 person-years), 879 cardiovascular deaths were observed. The median daily intake of LCn3FA was 0.37% kcal (0.86 g/day). Adjusted HR for CVD mortality was lower in the highest quartile of LCn3FA intake (HR 0.80; 95% CI 0.66-0.96) compared with the lowest quartile, and the trend was statistically significant (P = 0.038). The similar but statistically non-significant trends were observed for coronary heart disease death and stroke death. In analyses by age groups, the inverse associations of LCn3FA intake with the risk of total CVD death and stroke death were significant in younger individuals (30-59 years at baseline).
CONCLUSION
LCn3FA intake was inversely and independently associated the long-term risk of total CVD mortality in a representative sample of Japanese with high LCn3FA intake.
Department of Health Science, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan. Electronic address: naocom@belle.shiga-med.ac.jp.Department of Health Science, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan; Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan.Section of the National Health and Nutrition Survey, National Institute of Health and Nutrition, Tokyo, Japan.Department of Health Science, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan.Department of Health Science, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan.Department of Epidemiology and Public Health, Kanazawa Medical University, Ishikawa, Japan.Cardiovascular Epidemiology, Kyoto Women's University, Kyoto, Japan.Faculty of Health and Nutrition, Bunkyo University, Chigasaki, Japan.Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.Department of Health Science, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan.Department of Health Science, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan; Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan.Department of Food Science and Nutrition, Osaka City University, Osaka, Japan.Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan.Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan.Department of Preventive Medicine and Public Health, Keio University, Tokyo, Japan.The First Institute for Health Promotion and Health Care, Japan Anti-Tuberculosis Association, Tokyo, Japan.Department of Health Science, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan; Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan.No affiliation info available MeSH
AdultAgedAsian Continental Ancestry GroupCardiovascular DiseasesCohort StudiesDietFatty Acids, Omega-3FemaleFollow-Up StudiesHumansJapanMaleMiddle AgedMultivariate AnalysisProportional Hazards ModelsRisk FactorsTreatment Outcome
Pub Type(s)
Journal Article
Research Support, Non-U.S. Gov't
