Synergy between cannabidiol, cannabidiolic acid, and Δ⁹-tetrahydrocannabinol in the regulation of emesis in the Suncus murinus (house musk shrew).
Behav Neurosci 2015; 129(3):368-70BN

Abstract

Smoked marijuana contains over 100 different cannabinoids, including the psychoactive compound Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC, CBD, and its acidic precursor, cannabidiolic acid (CBDA), have all been shown to have antiemetic properties in the Suncus murinus (S. murinus; house musk shrew). Here we show that when subthreshold antiemetic doses of CBD (2.5 mg/kg ip) or CBDA (0.05 mg/kg ip) are combined with a subthreshold antiemetic dose of THC (1 mg/kg ip) in the S. murinus, both lithium-chloride-induced vomiting and abdominal retching are dramatically suppressed. These results suggest that combined effects of these compounds may lead to better control of vomiting with fewer side effects.

Links

  • Publisher Full Text
    • Aggregator Full Text

    Authors+Show Affiliations

    Rock EM
    Department of Psychology, University of Guelph.
    Parker LA
    Department of Psychology, University of Guelph.

    MeSH

    AnimalsAntiemeticsCannabidiolCannabinoidsDisease Models, AnimalDronabinolDrug Therapy, CombinationFemaleLithium ChlorideMaleShrewsVomiting

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26030435