[Prevention of stomatitis induced by anti-cancer drugs].
Gan To Kagaku Ryoho. 1989 Oct; 16(10):3449-51.GT

Abstract

A randomized control trial study was carried out to evaluate the effect of allopurinol mouth wash on stomatitis induced by chemotherapy in gynecologic patients. Chemotherapeutics used consisted of 5-FU+CDDP (PF) given to 10 patients and vincristine and actinomycin-D+cyclophosphamide (VAC) given to 5. Allopurinol mouth wash was prepared for patients to rinse their mouth with the solution 4-5 times daily before and after treatment with anti-cancer drugs. The Japan Society For Cancer Therapy's criteria for stomatitis were used. In the control group, stomatitis occurred in 9 of the 10 patients receiving PF therapy and in all of the 5 receiving VAC. In contrast, stomatitis was observed in only 2 of the 10 patients receiving PF therapy and 2 of the 5 VAC in the allopurinol-treated group. Allopurinol mouth wash showed a marked effect on stomatitis induced by chemotherapy.

Authors+Show Affiliations

Dozono H
Dept. of Gynecology, Faculty of Medicine, Kagoshima University.
Nakamura K
No affiliation info available
Motoya T
No affiliation info available
Nakamura S
No affiliation info available
Shinmura R
No affiliation info available
Miwa K
No affiliation info available
Ishibashi M
No affiliation info available
Nagata Y
No affiliation info available

MeSH

AllopurinolAntineoplastic Combined Chemotherapy ProtocolsClinical Trials as TopicCyclophosphamideDactinomycinFemaleFluorouracilGenital Neoplasms, FemaleHumansMouth MucosaMouthwashesRandom AllocationStomatitisVincristine

Pub Type(s)

Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial

Language

jpn

PubMed ID

2679397