Di (2-ethylhexyl) phthalate (DEHP) is the most detected and concentrated plasticizer in environment and wastewaters, worldwide. In this study, different operating parameters such as current intensity, treatment time, type of anodes, and supporting electrolytes were tested to optimized the electro-oxidation process (EOP) for the removal of DEHP in the presence of methanol as a dissolved organic matter. Among the anodes, the Nb/BDD showed the best degradation rate of DEHP, at low current intensity of 0.2 A after 90 min of treatment time with a percentage of degradation recorded of 81 %, compared to 70 % obtained with the Ti/IrO2-RuO2. Furthermore, due to the combination of direct and indirect oxidation, the removal of DEHP in the presence of 1 g/L Na2SO4 was higher than NaBr, even though the oxidant production of NaBr was 11.7 mmol/L against 3.5 mmol/L recorded in the presence of sulfate at 0.5 A and after 60 min of electrolysis time. Under optimal condition (current intensity = 0.5 A, time = 120 min, using Nb/BDD anode and Na2SO4 as supporting electrolyte), the removal of 87.2 % of DEHP was achieved. The total cost of 0.106 US$/m(3) of treated water was achieved based on economical optimization of reactor with current intensity of 0.2 A and 1 g/L Na2SO4.