Independent prognostic role of PD-L1expression in patients with esophageal squamous cell carcinoma.
Oncotarget. 2017 Jan 31; 8(5):8315-8329.O

Abstract

Accumulating evidence has shown that PD-L1 expression is associated with clinicopathological features in various human malignancies. We searched for correlations between PD-L1 expression and clinicopathological data in esophageal squamous cell carcinoma (ESCC) patients. PD-L1 expression in primary tumors from 278 patients was evaluated using immunohistochemistry (IHC) in ESCC tissue microarray. Survival curves were constructed by using the Kaplan-Meier method. Univariate and multivariate Cox proportional hazard regression models were performed to identify associations with outcome variables. Overall, tumoral PD-L1 expression (≥10%, 20% or 30% as cut-off value) was associated with favorable DFS and OS upon multivariate analysis. When the patients stratified into stage I-II (168, 60.4%) and stage III-IV (110, 39.6%), or with lymph node metastasis (133, 47.8%), the prognostic role was not consistent. In patients with stage I-II disease, tumoral PD-L1 expression (≥5%, 10%, 20% or 30%) was associated with better DFS and OS upon multivariate analysis. In patients without lymph node metastasis, tumoral PD-L1 expression (≥1%, 5%, 10%, 20%, or 30%) was associated with improved DFS and OS in univariate or multivariate analysis. However, PD-L1 expression was not correlated with prognosis in patients with stage III-IV disease or with lymph node metastasis. Our results for the first time showed the prognostic role of tumoral PD-L1 expression was variable in different stages and lymph node status of ESCC. Tumoral PD-L1 expression was independent favorable predictor in ESCC patients with Stage I-II disease or without lymph node metastasis, not in stage III-IV or lymph node metastasis.

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ncbi.nlm.nih.gov
impactjournals.com
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Authors+Show Affiliations

Jiang D
Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
Song Q
Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
Wang H
Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
Huang J
Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
Wang H
Department of thoracic surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
Hou J
Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
Li X
Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
Xu Y
Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
Sujie A
Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
Zeng H
Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
Tan L
Department of thoracic surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
Hou Y
Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China. Department of Pathology, School of Basic Medical Sciences & Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.

MeSH

AdultAgedAged, 80 and overB7-H1 AntigenBiomarkers, TumorCarcinoma, Squamous CellChi-Square DistributionDisease ProgressionDisease-Free SurvivalEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaFemaleHumansImmunohistochemistryKaplan-Meier EstimateLymphatic MetastasisMaleMiddle AgedMultivariate AnalysisNeoplasm StagingProportional Hazards ModelsRetrospective StudiesRisk FactorsTime FactorsTissue Array AnalysisTreatment Outcome

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28039448