Ovarian Teratoma Associated with Coexisting Anti-N-Methyl-D-Aspartate Receptor and Glial Fibrillary Acidic Protein Autoimmune Meningoencephalitis in an Adolescent Girl: A Case Report.
J Pediatr Adolesc Gynecol. 2018 Jun; 31(3):321-324.JP

Abstract

BACKGROUND

Ovarian teratomas are rarely associated with paraneoplastic autoimmune meningoencephalitis. In addition to the well known N-methyl-D-aspartate receptor (NMDA-R) antibody, the glial fibrillary acidic protein (GFAP) antibody is a novel biomarker of autoimmune meningoencephalitis that might be seen in patients with ovarian teratoma.

CASE

A 13-year-old girl with acute-onset meningoencephalitis and incidental finding of ovarian teratoma was found to have coexisting anti-NMDA-R and GFAP antibodies present in her cerebrospinal fluid.

SUMMARY AND CONCLUSION

NMDA-R and GFAP autoimmune encephalitis should be considered in adolescent patients with neurologic or psychiatric symptoms and an ovarian teratoma. Prompt diagnosis and surgical resection increase the likelihood of full neurologic recovery.

Links

Publisher Full Text
Aggregator Full Text

Authors+Show Affiliations

Martin AL
Department of Obstetrics, Gynecology and Women's Health, University of Louisville School of Medicine, Louisville, Kentucky. Electronic address: almart15@louisville.edu.
Jolliffe E
Department of Neurology, Mayo Clinic, Rochester, Minnesota.
Hertweck SP
Department of Pediatric and Adolescent Gynecology, Norton Children's Hospital, Louisville, Kentucky.

MeSH

AdolescentAnti-N-Methyl-D-Aspartate Receptor EncephalitisBiomarkersFemaleGlial Fibrillary Acidic ProteinHumansLaparoscopyMeningoencephalitisOvarian NeoplasmsOvaryReceptors, N-Methyl-D-AspartateTeratomaUltrasonography

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

29294378