[Differences in serum selenium concentration in probands and patients with colorectal neoplasms in Zagreb, Croatia].
Acta Med Austriaca 1994; 21(1):19-23AM

Abstract

Serum selenium concentration (scSe) (microgram/l) was comparatively measured in healthy persons (n = 202), patients with colorectal adenoma(s) (n = 44) and colorectal carcinoma (n = 48). In patients with adenoma(s) scSe (59.05 +/- 15) was significantly lower (p < 0.001) compared with scSe in the control group (66.8 +/- 14.43). Hyposelenemia was more pronounced in patients with multiple polyps (n = 11) than in patients with single adenoma (n = 33) (p < 0.05). Patients with colorectal carcinoma had also significant decrease in scSe (50.93 +/- 13.81) compared with the control group (p < 0.001 and with the adenoma patients (p < 0.001). According to the analysis of variance, highly significant differences were found among the cancer patients stratified in Dukes' stages A to D (p < 0.001), indicating a strong negative correlation between extension of cancer and hyposelenemia. Furthermore, hyposelenemia seemed to be more pronounced in the mucinous type of carcinoma than in adenocarcinoma (p = 0.056). This results indicate that hyposelenemia is strongly associated with colorectal neoplasia (including extension and severity of the disease) and that it may not only be a result but also one of tumorogenic factors. That means that selenium supplementation could be important in prevention or even adjuvant therapy of colorectal cancer.

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  • Authors+Show Affiliations

    Vucelic B
    Gastroenterologischen Abteilung der Inneren Klinik, Universitätsklinik, Rebro, Zagreb, Kroatien.
    Buljevac M
    No affiliation info available
    Romic Z
    No affiliation info available
    Milicic D
    No affiliation info available
    Ostojic R
    No affiliation info available
    Krznaric Z
    No affiliation info available

    MeSH

    Adenomatous Polyposis ColiAdultAgedAged, 80 and overColonic PolypsColorectal NeoplasmsCroatiaFemaleHumansMaleMiddle AgedNeoplasm StagingReference ValuesRisk FactorsSelenium

    Pub Type(s)

    English Abstract
    Journal Article

    Language

    ger

    PubMed ID

    8017164