The treatment of tumors of the eyelids must extend not only to complete removal or destruction of the neoplasm, but also to the maintenance of physiology functions. In addition, cosmetic aspects should be taken into consideration. In a prospective study, 278 cryosurgical operations performed for lid tumors in the years from 1980 to 1985 were followed up for 5 years to decide whether cryotherapy fulfilled these demands. We used spray freezing with liquid nitrogen, because the low temperatures and high freezing rates required for cell destruction are achieved only by this technique. The 5-year recurrence rate was 3.5%. The liquid nitrogen therapy is especially suitable when the eye lids are operated on, because the lacrimal system remains functional. Gas expansion cryotherapy should not be used in in the treatment of tumors, as it may lead to stimulation of growth.