Human T-lymphotropic virus type II infection in Vietnamese thalassemic patients.
Arch Virol. 1997; 142(7):1429-40.AV

Abstract

Anti-human T-lymphotropic virus type I/II (HTLV-I/II) antibodies were screened by particle agglutination test in a total of 66 patients with thalassemia major who received multiple transfusion from paid donors at the Blood Transfusion Hematology Center of Ho Chi Minh City in South Vietnam. HTLV-II infection was confirmed in 6 patients (9.1%) by Western blot analysis and/or polymerase chain reaction. Phylogenetic analysis revealed that long terminal repeat sequences of HTLV-II proviruses from 5 thalassemic patients in Vietnam belonged to the same phylogenetic subgroup of HTLV-IIb as those from intravenous drug abusers in North America and Europe. These data shed light on the route of introducing HTLV-II into Vietnam.

Authors+Show Affiliations

Lin MT
Department of Oncology, Blood Transfusion Hematology Center, Ho Chi Minh City, Vietnam.
Nguyen BT
No affiliation info available
Binh TV
No affiliation info available
Be TV
No affiliation info available
Chiang TY
No affiliation info available
Tseng LH
No affiliation info available
Yang YC
No affiliation info available
Lin KH
No affiliation info available
Chen YC
No affiliation info available

MeSH

AdolescentAgglutination TestsBase SequenceChildChild, PreschoolFemaleGene Products, envGenes, envHTLV-II AntibodiesHTLV-II InfectionsHuman T-lymphotropic virus 2HumansInfantMaleMolecular Sequence DataPhylogenyPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthPrevalenceProvirusesRepetitive Sequences, Nucleic AcidRetroviridae Proteins, OncogenicVietnambeta-Thalassemiaenv Gene Products, Human Immunodeficiency Virus

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9267453