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1,512,330 results
  • StatPearls: Cesarean Section [BOOK]
    StatPearls Publishing: Treasure Island (FL) Sung Sharon S Sparrow Hospital Mahdy Heba H BOOK
  • Cesarean section is a fetal delivery through an open abdominal incision (laparotomy) and an incision in the uterus (hysterotomy). The first cesarean documented occurred in 1020 AD, and since then the procedure has evolved tremendously.[1]  It is now the most common surgery performed in the United States, with over 1 million women delivered by cesarean every year. The cesarean delivery rate rose f…
  • The Pathogenesis of Primary Biliary Cholangitis: A Comprehensive Review. [Journal Article]
    Semin Liver Dis 2019Lleo A, Leung PSC, … Gershwin EM
  • Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by autoimmune destruction of small to medium size intrahepatic bile ducts. The etiology of PBC remains unknown and pathogenesis features immune-mediated biliary injury, alongside the consequences of chronic cholestasis. PBC is strongly associated with the loss of immune tolerance against mitochondrial antigens …
  • Phosphodiesterase inhibitors say NO to Alzheimer's disease. [Review]
    Food Chem Toxicol 2019; :110822Nabavi SM, Talarek S, … Farzaei MH
  • Phosphodiesterases (PDEs) consisted of 11 subtypes (PDE1 to PDE11) and over 40 isoforms that regulate levels of cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP), the second messengers in cell functions. PDE inhibitors (PDEIs) have been attractive therapeutic targets due to their involvement in diverse medical conditions, e.g. cardiovascular diseases, autoimmune dise…
  • Mitochondria modulatory effects of new TSPO ligands in a cellular model of tauopathies. [Journal Article]
    J Neuroendocrinol 2019; :e12796Grimm A, Lejri I, … Eckert A
  • Translocator protein 18 kDa (TSPO) is a mitochondrial protein located in the outer membrane and involved in cholesterol translocation, a prerequisite for steroid biosynthesis. TSPO modulation seems also to play a role in other mitochondrial function, including mitochondrial respiration and cell survival. In the central nervous system, its expression is upregulated in neuropathology such as Alzhei…
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