- Magnetic hydrogel particles improve nanopore sequencing of SARS-CoV-2 and other respiratory viruses. [Journal Article]Sci Rep. 2023 Feb 07; 13(1):2163.SR
- Presented here is a magnetic hydrogel particle enabled workflow for capturing and concentrating SARS-CoV-2 from diagnostic remnant swab samples that significantly improves sequencing results using the Oxford Nanopore Technologies MinION sequencing platform. Our approach utilizes a novel affinity-based magnetic hydrogel particle, circumventing low input sample volumes and allowing for both rapid m…
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- COVID drug drives viral mutations - and now some want to halt its use. [News]Nature. 2023 Feb 07 [Online ahead of print]Nat
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- An abundance of antibiotics, and more - this week's best science graphics. [News]Nature. 2023 Feb 07 [Online ahead of print]Nat
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- Global pandemic treaty: what we must learn from climate-change errors. [News]Nature. 2023 Feb; 614(7947):195-196.Nat
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- Relative effectiveness of COVID-19 vaccination and booster dose combinations among 18.9 million vaccinated adults during the early SARS-CoV-2 Omicron period - United States, January 1, 2022-March 31, 2022. [Journal Article]Clin Infect Dis. 2023 Feb 08 [Online ahead of print]CI
- Small sample sizes have limited prior studies' ability to capture severe COVID-19 outcomes, especially among Ad26.COV2.S vaccine recipients. This study of 18.9 million adults aged ≥18 years assessed relative vaccine effectiveness (rVE) in three recipient cohorts: (1) primary Ad26.COV2.S vaccine and Ad26.COV2.S booster (two Ad26.COV2.S), (2) primary Ad26.COV2.S vaccine and mRNA booster (Ad26.COV2.…
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- The role of digital technology in surgical home hospital programs. [Review]NPJ Digit Med. 2023 Feb 07; 6(1):22.ND
- Home hospital (HH), a care delivery model of providing hospital-grade care to patients in their homes, has become increasingly common in medical settings, though surgical uptake has been limited. HH programs have been shown to be safe and effective in a variety of medical contexts, with increased usage of this care pathway during the COVID-19 pandemic. Though surgical patients have unique clinica…
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- Optimal spatial evaluation of a pro rata vaccine distribution rule for COVID-19. [Journal Article]Sci Rep. 2023 Feb 07; 13(1):2194.SR
- The COVID-19 Vaccines Global Access (COVAX) is a World Health Organization (WHO) initiative that aims for an equitable access of COVID-19 vaccines. Despite potential heterogeneous infection levels across a country, countries receiving allotments of vaccines may follow WHO's allocation guidelines and distribute vaccines based on a jurisdictions' relative population size. Utilizing economic-epidemi…
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- Author Correction: Measuring sensitivity to social distancing behavior during the COVID-19 pandemic. [Published Erratum]Sci Rep. 2023 Feb 07; 13(1):2192.SR
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- Fall of viral and bacterial pneumonia hospitalizations following COVID-19 pandemic mitigation strategies: a central Italian Region retrospective study. [Journal Article]Intern Emerg Med. 2023 Feb 07 [Online ahead of print]IE
- Community-Acquired Pneumonia (CAP) represents one of the first causes of hospitalization and death in the elderly all over the world and weighs heavily on public health system. Since the beginning of the COVID-19 (CoronaVirus Disease-19) pandemic, everybody's behavior was forced to change, as the result of a global lockdown strategy and the obligation of using personal protection equipment (PPE).…
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- Racial and Ethnic Disparities in Coexisting Cancer and COVID-19 Mortality. [Letter]J Gen Intern Med. 2023 Feb 07 [Online ahead of print]JG
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- Visual and quantitative assessment of hip implant-related metal artifacts at low field MRI: a phantom study comparing a 0.55-T system with 1.5-T and 3-T systems. [Journal Article]Eur Radiol Exp. 2023 Feb 08; 7(1):5.ER
- CONCLUSIONS: Artifact intensity was lowest for Ti alloys at 0.55 T. For other alloys, it was similar at 0.55 T and 1.5 T, higher at 3 T. Despite an inferior gradient system and a larger bore width, the 0.55-T system showed the same artifact intensity of the 1.5-T system.
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- Prospective cohort study of Cryptosporidium infection and shedding in infants and their households. [Journal Article]Clin Infect Dis. 2023 Feb 08 [Online ahead of print]CI
- CONCLUSIONS: In this intensive, longitudinal study of Cryptosporidium infection in families we found high rates of cryptosporidiosis in infants and children, and prolonged parasite shedding, especially among malnourished children. These data support that transmission within the household is an important route of exposure for young infants, and that treatment of non-diarrheal infection to interrupt person-to-person transmission within the home may be essential for preventing cryptosporidiosis in infants.
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- Impact of COVID-19 Pandemic on HIV Testing Uptake Among Key Populations Enrolled in Targeted Intervention Program in Maharashtra, India. [Journal Article]AIDS Behav. 2023 Feb 07 [Online ahead of print]AB
- The COVID-19 pandemic posed unprecedented challenges to HIV services globally. We evaluated the impact of the COVID-19 pandemic on the uptake of HIV testing in the Targeted Intervention (TI) program in Maharashtra-a high HIV burden state in India. Annual HIV testing was sustained during the pandemic year (2020-2021), at levels similar to the pre-pandemic year (2019-2020), among Female Sex Workers…
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- [Long-term care facilities-the COVID-19 pandemic as an urgent call: infection prevention, control measures, and factors influencing the health of residents]. [Review]Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2023 Feb 07 [Online ahead of print]BG
- The COVID-19 pandemic once again highlighted the vulnerability of residents of long-term care facilities due to their increased risk of a severe or fatal course of COVID-19. To protect the residents in the face of high incidences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2) in the general population, a number of measures for infection protection were recommended, which led to a…
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- Effect of COVID-19 (SARS-CoV-2) Vaccination on Patients with Atopic Dermatitis Treated with Dupilumab: A Multicenter, Observational Study. [Journal Article]Ann Dermatol. 2023 Feb; 35(1):38-45.AD
- CONCLUSIONS: No serious adverse reactions were observed in patients with AD after COVID-19 vaccination. Exacerbation of pruritus and AD symptoms was observed but was mostly mild and transient.
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- Comparison of faecal calprotectin using two collection and extraction strategies for the BÃHLMANN CALEX® Cap â possible implications for clinical cut-offs? [Journal Article]Ann Clin Biochem. 2023 Feb 07 [Online ahead of print]AC
- CONCLUSIONS: The study shows that collection of a faecal sample using the CALEX® Cap works well and is a good alternative to using standard containers. The correlation gives rise to the possibility that faecal calprotectin is not stable when collected into standard collection containers. Prior to further roll-out of this process, questions surrounding the current cut-offs would need to be addressed.
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- Concordance in COVID-19 serology, bone mineralisation, and inflammatory analytes between venous and self-collected capillary blood samples exposed to various pre-analytical conditions. [Journal Article]Ann Clin Biochem. 2023 Feb 07 [Online ahead of print]AC
- CONCLUSIONS: These findings suggest that remote blood collection devices can be used to measure anti-SARS-CoV-2 IgG, 25(OH)D, CRP, and ALP. Further analysis is required to evaluate the interchangeability between venous and capillary testing in Ca and Ph levels, which are more sensitive to pre-analytical conditions.
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- Telehealth's future in Australian Primary Health Care: Lessons from the COVID-19 Pandemic. [Journal Article]BJGP Open. 2023 Feb 07 [Online ahead of print]BO
- CONCLUSIONS: Providers required resilience and flexibility to adapt to telehealth. Funding models mustreward providers from an outcome focus, rather than placing limits on telehealth's use.Hybrid approaches to service delivery will best meet the needs of the community but mustbe accompanied by support and education for PHC professionals.
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- T Cell Responses to SARS-CoV-2. [Review]Annu Rev Immunol. 2022 Feb 07 [Online ahead of print]AR
- A large body of evidence generated in the last two and a half years addresses the roles of T cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces multi-epitope CD4 and CD8 T cell responses with polyfunctionality. Early T cell responses have been associated with mild COVID-19 outcomes. In concert with animal model data, these results suggest that while antibody…
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- Unusual case of propofol-related infusion syndrome complicating severe COVID-19 ARDS. [Journal Article]BMJ Case Rep. 2023 Feb 07; 16(2)BC
- An elderly man presenting with shortness of breath and hypoxaemia was admitted with acute hypoxic respiratory failure secondary to COVID-19 pneumonia. Due to worsening hypoxaemia, he was transferred to the intensive care unit and required mechanical ventilation. Propofol was infused at 1.5-4 mg/kg/hour. Within 48 hours of initiation, we noticed worsening metabolic acidosis, acute kidney injury, h…
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- Anxiety and stress among healthcare professionals during COVID-19 in Ethiopia: systematic review and meta-analysis. [Journal Article]BMJ Open. 2023 Feb 07; 13(2):e070367.BO
- CONCLUSIONS: COVID-19 pandemic highly affects mental health of healthcare professionals in Ethiopia. Anxiety and stress were among reported mental health problems among healthcare professionals during the pandemic. Timely psychological counselling programmes should be applied for healthcare professionals to improve the general mental health problems.
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- Canadians' opinions towards COVID-19 data-sharing: a national cross-sectional survey. [Journal Article]BMJ Open. 2023 Feb 07; 13(2):e066418.BO
- CONCLUSIONS: These findings suggest that the Canadian public is generally favourable to deidentified data-sharing. Identifying factors that are likely to improve attitudes towards data-sharing are useful to stakeholders involved in data-sharing initiatives, such as public health agencies, in informing the development of public health communication and data-sharing policies. As Canada progresses through the COVID-19 pandemic, and with limited testing and reporting of COVID-19 data, it is essential to improve deidentified data-sharing given the public's general support for these efforts.
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- Health and economic benefits of achieving contraceptive and maternal health targets in Small Island Developing States in the Pacific and Caribbean. [Journal Article]BMJ Glob Health. 2023 Feb; 8(2)BG
- CONCLUSIONS: Achieving full coverage of contraceptive and MH services in the Pacific and Caribbean is likely to have a high return on investment.
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- Physician perceptions of restrictive visitor policies during the COVID-19 pandemic: a qualitative study. [Journal Article]CMAJ Open. 2023 Jan-Feb; 11(1):E110-E117.CO
- CONCLUSIONS: Our study highlights substantial negative consequences of restrictive visitor policies, with heightened effects on older adults and people who did not speak English. Research is required to identify whether the benefits of visitor restrictions on infection control outweigh the numerous deleterious consequences to patients, families and care providers.
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- The History of Extracorporeal Membrane Oxygenation and the Development of Extracorporeal Membrane Oxygenation Anticoagulation. [Journal Article]Semin Thromb Hemost. 2023 Feb 07 [Online ahead of print]ST
- Extracorporeal membrane oxygenation (ECMO) was first started for humans in early 1970s by Robert Bartlett. Since its inception, there have been numerous challenges with extracorporeal circulation, such as coagulation and platelet activation, followed by consumption of coagulation factors and platelets, and biocompatibility of tubing, pump, and oxygenator. Unfractionated heparin (heparin hereafter…
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- COVID-19: Understanding the impact of anti-hypertensive drugs and hydroxychloroquine on the ACE1 and ACE2 in lung and adipose tissue in SHR and WKY rats. [Journal Article]Physiol Rep. 2023 Feb; 11(3):e15598.PR
- Hypertensive individuals taking anti-hypertensive drugs from renin-angiotensin system inhibitors may exhibit a more severe evolution of the disease when contracting the SARS-CoV-2 virus (COVID-19 disease) due to potential increases in ACE2 expression. The study investigated ACE1 and ACE2 axes and hydroxychloroquine in the lungs and adipose tissue of male and female normotensive Wistar Kyoto (WKY)…
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- Quality Of Life and Coping With Stress in Relatives of Patients in Intensive Care Units During COVID-19. [Journal Article]Am J Crit Care. 2023 Feb 08 [Online ahead of print]AJ
- CONCLUSIONS: In addition to the uncertainty and fear associated with the COVID-19 pandemic, it is very distressing to have a relative who is a patient in the intensive care unit. In this context, it is especially important to improve the level of coping with stress of the relatives of patients in the intensive care unit and to increase their quality of life.
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- Hyaluronan in the Pathogenesis of Acute and Post-Acute COVID-19 Infection. [Review]Matrix Biol. 2023 Feb 05 [Online ahead of print]MB
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently emerged as the cause of a global pandemic. Infection with SARS-CoV-2 can result in COVID-19 with both acute and chronic disease manifestations that continue to impact many patients long after the resolution of viral replication. There is therefore great interest in understanding the host factors that contribute to COVID-19 path…
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- Learning from community-based HIV prevention to inform control and mitigation of the COVID-19 pandemic. [Journal Article]Prev Med. 2023 Feb 05 [Online ahead of print]PM
- The current COVID-19 pandemic and the likelihood of future viral pandemics demonstrate a need for strategic prevention campaigns that integrate biomedical, structural, and behavioral interventions within larger scale comprehensive public health initiatives. In Human Immunodeficiency Virus (HIV) prevention, community-based efforts have resulted in reductions in transmission rates, increases in tes…
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- [Neglected differentiations: Of relative and absolute risk reduction and of seat belts and vaccines]. [Journal Article]Dtsch Med Wochenschr. 2023 Feb; 148(4):192-197.DM
- It is often reported that established COVID-19 vaccines have an efficacy of 70 % or more in preventing serious illnesses or deaths. On the other hand, critics claim that the vaccines have actually shown less than 1 % efficacy in studies and are therefore of little use. Which statement is correct? And where do these discrepancies come from?
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