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(("Novel Coronavirus" OR COVID-19 OR SARS-CoV-2 OR 2019-nCoV) AND (Laboratory Diagnosis OR Clinical Laboratory OR Diagnostic testing OR Serology OR RT-PCR))
5,343 results
  • Neuropathologic features of four autopsied COVID-19 patients. [Letter]
    Brain Pathol. 2020 Aug 06 [Online ahead of print]Kantonen J, Mahzabin S, … Myllykangas L
  • Published descriptions of the neuropathological features of COVID-19 patients have been controversial, ranging from only modest or no pathology to severe hypoxic and hemorrhagic phenotypes, thrombotic complications, acute disseminated encephalomyelitis-like changes, and encephalitis and meningitis. Here we describe the neuropathological findings of four COVID-19-positive patients autopsied at the…
  • Is the COVID-19 thrombotic catastrophe complement-connected? [Review]
    J Thromb Haemost. 2020 Aug 06 [Online ahead of print]Conway EM, Pryzdial ELG
  • In December 2019, the world was introduced to a new betacoronavirus, referred to as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for its propensity to cause rapidly progressive lung damage, resulting in high death rates. As fast as the virus spread, it became evident that COVID-19 is a multi-system disease, that may involve multiple organs, and has a high risk of thrombosis, assoc…
  • Invasive mechanical ventilation using a bilevel PAP ST device in a healthy swine model. [Journal Article]
    Sleep Breath. 2020 Aug 06 [Online ahead of print]Foster BE, Diaz-Abad M, … Robertson BD
  • CONCLUSIONS: Commercially available bilevel PAP ST can provide invasive ventilation with a single limb respiratory circuit and in-line filters to control oxygenation and ventilation without significant rebreathing in a swine model. Further study is needed to evaluate safety and efficacy in clinical disease models. In the setting of a ventilator shortage during the COVID-19 pandemic, and in other resource-constrained situations, these devices may be considered as an effective alternative means for invasive ventilation.
  • Clinical study using mesenchymal stem cells for the treatment of patients with severe COVID-19. [Letter]
    Front Med. 2020 Aug 06 [Online ahead of print]Tang L, Jiang Y, … Li L
  • The Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 was identified in December 2019. The symptoms include fever, cough, dyspnea, early symptom of sputum, and acute respiratory distress syndrome (ARDS). Mesenchymal stem cell (MSC) therapy is the immediate treatment used for patients with severe cases of COVID-19. Herein, we describe two confirmed cases of COVID-19 in Wuhan to explore the …
  • A citizen science initiative for open data and visualization of COVID-19 outbreak in Kerala, India. [Journal Article]
    J Am Med Inform Assoc. 2020 Aug 06 [Online ahead of print]Ulahannan JP, Narayanan N, … Vellichirammal NN
  • CONCLUSIONS: We anticipate that our dataset can form the basis for future studies, supplemented with clinical and epidemiological data from the individuals affected with COVID-19 in Kerala.We reported a citizen science initiative on the COVID-19 outbreak in Kerala to collect and deposit data in a structured format, which was utilized for visualizing the outbreak trend and describing demographic characteristics of affected individuals.
  • Evaluation of serological tests for SARS-CoV-2: Implications for serology testing in a low-prevalence setting. [Journal Article]
    J Infect Dis. 2020 Aug 06 [Online ahead of print]Bond K, Nicholson S, … Williamson DA
  • CONCLUSIONS: Performance characteristics for COVID-19 serological assays were generally lower than those reported by manufacturers. Timing of specimen collection relative to onset of illness or infection is crucial in the reporting of performance characteristics for COVID-19 serological assays. The optimal algorithm for implementing serological testing for COVID-19 remains to be determined, particularly in low-prevalence settings.
  • Deep Learning-Based Decision-Tree Classifier for COVID-19 Diagnosis From Chest X-ray Imaging. [Journal Article]
    Front Med (Lausanne). 2020; 7:427.Yoo SH, Geng H, … Lee H
  • The global pandemic of coronavirus disease 2019 (COVID-19) has resulted in an increased demand for testing, diagnosis, and treatment. Reverse transcription polymerase chain reaction (RT-PCR) is the definitive test for the diagnosis of COVID-19; however, chest X-ray radiography (CXR) is a fast, effective, and affordable test that identifies the possible COVID-19-related pneumonia. This study inves…
  • Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels. [Journal Article]
    Int J Biol Sci. 2020; 16(13):2382-2391.Xiang Z, Liu J, … Yang Z
  • COVID-19 is a public health emergency that has rapidly spread to over 200 countries and regions, and no effective treatment has been established to date. Severe and critical cases have been associated with higher mortality due to acute respiratory distress syndrome (ARDS) and cytokine storm. Based on the novelty and recent emergence of COVID-19, no effective treatment regimen has been identified,…
  • SARS-CoV-2 infection in China-Before the pandemic. [Review]
    PLoS Negl Trop Dis. 2020 Aug; 14(8):e0008472.Liang H, Zheng L, … Tang J
  • In order to rapidly inform polices in the international response to the ongoing pandemic of coronavirus disease 19 (COVID-19), we summarize in this review current evidence on epidemiological and clinical features of the infection, transmission routes, problems of nucleic-acid testing, the epidemiological trend in China and impact of interventional measures, and some lessons learned. We concluded …
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