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(("Novel Coronavirus" OR COVID-19 OR SARS-CoV-2 OR 2019-nCoV) AND (Laboratory Diagnosis OR Clinical Laboratory OR Diagnostic testing OR Serology OR RT-PCR))
30,969 results
  • Rapid determination of infectious SARS-CoV-2 in PCR-positive samples by SDS-PMA assisted RT-qPCR. [Journal Article]
    Sci Total Environ. 2021 Jul 17; 797:149085.Hong W, Xiong J, … Wei H
  • The ongoing COVID-19 pandemic has generated a global health crisis that needs well management of not only patients but also environments to reduce SARS-CoV-2 transmission. The gold standard RT-qPCR method is sensitive and rapid to detect SARS-CoV-2 nucleic acid, but does not answer if PCR-positive samples contain infectious virions. To circumvent this problem, we report an SDS-propidium monoazide…
  • Optimizing testing for COVID-19 in India. [Journal Article]
    PLoS Comput Biol. 2021 Jul; 17(7):e1009126.Cherian P, Krishna S, Menon GI
  • COVID-19 testing across India uses a mix of two types of tests. Rapid Antigen Tests (RATs) are relatively inexpensive point-of-care lateral-flow-assay tests, but they are also less sensitive. The reverse-transcriptase polymerase-chain-reaction (RT-PCR) test has close to 100% sensitivity and specificity in a laboratory setting, but delays in returning results, as well as increased costs relative t…
  • Inhalable nanocatchers for SARS-CoV-2 inhibition. [Journal Article]
    Proc Natl Acad Sci U S A. 2021 Jul 20; 118(29)Zhang H, Zhu W, … Liu Z
  • The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2), presents an urgent health crisis. More recently, an increasing number of mutated strains of SARS-CoV-2 have been identified globally. Such mutations, especially those on the spike glycoprotein to render its higher binding affinity to human angiotensin-converti…
  • DIA-Based Proteome Profiling of Nasopharyngeal Swabs from COVID-19 Patients. [Journal Article]
    J Proteome Res. 2021 Jul 22 [Online ahead of print]Mun DG, Vanderboom PM, … Pandey A
  • Since the recent outbreak of COVID-19, there have been intense efforts to understand viral pathogenesis and host immune response to combat SARS-CoV-2. It has become evident that different host alterations can be identified in SARS-CoV-2 infection based on whether infected cells, animal models or clinical samples are studied. Although nasopharyngeal swabs are routinely collected for SARS-CoV-2 det…
  • Population Pharmacokinetics of Favipiravir in Patients with COVID-19. [Journal Article]
    CPT Pharmacometrics Syst Pharmacol. 2021 Jul 22 [Online ahead of print]Irie K, Nakagawa A, … Hashida T
  • The antiretroviral drug favipiravir inhibits RNA-dependent RNA polymerase. It has been developed for the treatment of novel coronavirus (SARS-CoV-2) infection disease (COVID-19). However, its pharmacokinetics in patients with COVID-19 is poorly understood. In this study, we measured favipiravir serum concentration by liquid chromatography-tandem mass spectrometry and conducted population pharmaco…
  • Quantifying Viral Particle Aerosolization Risk During Tracheostomy Surgery and Tracheostomy Care. [Journal Article]
    JAMA Otolaryngol Head Neck Surg. 2021 Jul 22 [Online ahead of print]Berges AJ, Lina IA, … Hillel AT
  • CONCLUSIONS: The findings of this laboratory and animal comparative effectiveness study indicate that tracheostomy surgery and tracheostomy care are associated with significant aerosol generation, putting health care workers at risk for viral transmission of airborne diseases. Combined HME and surgical mask coverage of the tracheostomy was associated with decreased aerosolization, thereby reducing the risk of viral transmission to health care workers.
  • Biochemical composition, transmission and diagnosis of SARS-CoV-2. [Journal Article]
    Biosci Rep. 2021 Jul 22 [Online ahead of print]Ahirwar R, Gandhi S, … Kumar S
  • Coronavirus disease 2019 (COVID-19) is a life-threatening respiratory infection caused by SARS-CoV-2, a novel human coronavirus. COVID-19 was declared a pandemic by World Health Organization in March 2020 for its continuous and rapid spread worldwide. Rapidly emerging COVID-19 epicenters and mutants of concerns have created mammoth chaos in healthcare sectors across the globe. With over 185 milli…
  • Seasonal Coronaviruses and Other Neglected Respiratory Viruses: A Global Perspective and a Local Snapshot. [Review]
    Front Public Health. 2021; 9:691163.Ljubin-Sternak S, Meštrović T, … Vraneš J
  • Respiratory viral infections are the leading cause of morbidity and mortality in the world; however, there are several groups of viruses that are insufficiently routinely sought for, and can thus be considered neglected from a diagnostic and clinical standpoint. Timely detection of seasonality of certain respiratory viruses (e.g., enveloped viruses such as seasonal coronaviruses) in the local con…
  • Association of anemia and COVID-19 in hospitalized patients. [Journal Article]
    Future Virol. 2021 JunChen C, Zhou W, … Zheng C
  • Aim: COVID-19 is a major threat to public health worldwide. A large proportion of COVID-19 patients is proved to develop anemia. Herein, we investigate the association between anemia and severe pneumonia. Materials & methods: 137 of COVID-19-confirmed patients admitted to Wuhan Union Hospital (Wuhan, China) from 13 February to 17 March 2020 were included. Their clinical characteristics and labora…
  • Saliva: Both a Threat and an Opportunity in Covid-19 Pandemic. [Review]
    Pak J Med Sci. 2021 Jul-Aug; 37(4):1215-1220.Sadikoglu IS, Caymaz MG
  • Covid-19 pandemic, continues all over the world with the increasing number of confirmed cases and performed tests day by day. It has been shown that collecting nasopharyngeal samples, as the most commonly prefered method to perform RT-PCR, has disadvantages like causing discomfort and bleeding in patients. Sample collecting procedure also renders healthcare professionals by exposing them to the r…
  • Glycan Nanostructures of Human Coronaviruses. [Review]
    Int J Nanomedicine. 2021; 16:4813-4830.Guo W, Lakshminarayanan H, … Draz MS
  • Human coronaviruses present a substantial global disease burden, causing damage to populations' health, economy, and social well-being. Glycans are one of the main structural components of all microbes and organismic structures, including viruses-playing multiple essential roles in virus infection and immunity. Studying and understanding virus glycans at the nanoscale provide new insights into th…
  • Impact of repeated nasal sampling on detection and quantification of SARS-CoV-2. [Journal Article]
    Sci Rep. 2021 07 21; 11(1):14903.Levy JM, Frediani JK, … Waggoner JJ
  • The impact of repeated sample collection on COVID-19 test performance is unknown. The FDA and CDC currently recommend the primary collection of diagnostic samples to minimize the perceived risk of false-negative findings. We therefore evaluated the association between repeated sample collection and test performance among 325 symptomatic patients undergoing COVID-19 testing in Atlanta, GA. High co…
  • Metabolomic analyses reveals new stage-specific features of the COVID-19. [Journal Article]
    Eur Respir J. 2021 Jul 21 [Online ahead of print]Jia H, Liu C, … Liang H
  • The current pandemic of coronavirus disease 19 (COVID-19) has affected more than 160 million of individuals and caused millions of deaths worldwide at least in part due to the unclarified pathophysiology of this disease. Therefore, identifying the underlying molecular mechanisms of COVID-19 is critical to overcome this pandemic. Metabolites mirror the disease progression of an individual by acqui…
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