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(("Novel Coronavirus" OR COVID-19 OR SARS-CoV-2 OR 2019-nCoV) AND (N Engl J Med[TA] OR JAMA[TA] OR Science[TA] OR 2985213R[JID] OR BMJ[TA]) AND Journal Article[PT] NOT News[PT])
1,156 results
  • Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans. [Journal Article]
    Science. 2020 Aug 04 [Online ahead of print]Mateus J, Grifoni A, … Weiskopf D
  • Many unknowns exist about human immune responses to the SARS-CoV-2 virus. SARS-CoV-2 reactive CD4+ T cells have been reported in unexposed individuals, suggesting pre-existing cross-reactive T cell memory in 20-50% of people. However, the source of those T cells has been speculative. Using human blood samples derived before the SARS-CoV-2 virus was discovered in 2019, we mapped 142 T cell epitope…
  • Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2. [Journal Article]
    Science. 2020 Aug 04 [Online ahead of print]Chan KK, Dorosky D, … Procko E
  • The spike protein S of SARS coronavirus 2 (SARS-CoV-2) binds ACE2 on host cells to initiate entry, and soluble ACE2 is a therapeutic candidate that neutralizes infection by acting as a decoy. Using deep mutagenesis, mutations in ACE2 that increase S binding are found across the interaction surface, in the N90-glycosylation motif and at buried sites. The mutational landscape provides a blueprint f…
  • Association Between Statewide School Closure and COVID-19 Incidence and Mortality in the US. [Journal Article]
    JAMA. 2020 Jul 29 [Online ahead of print]Auger KA, Shah SS, … Thomson JE
  • CONCLUSIONS: Between March 9, 2020, and May 7, 2020, school closure in the US was temporally associated with decreased COVID-19 incidence and mortality; states that closed schools earlier, when cumulative incidence of COVID-19 was low, had the largest relative reduction in incidence and mortality. However, it remains possible that some of the reduction may have been related to other concurrent nonpharmaceutical interventions.
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