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(("Novel Coronavirus" OR COVID-19 OR SARS-CoV-2 OR 2019-nCoV) AND (N Engl J Med[TA] OR JAMA[TA] OR Science[TA] OR 2985213R[JID] OR BMJ[TA]) AND Journal Article[PT] NOT News[PT])
2,860 results
  • Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant. [Journal Article]
    N Engl J Med. 2021 Jul 21 [Online ahead of print]Lopez Bernal J, Andrews N, … Ramsay M
  • CONCLUSIONS: Only modest differences in vaccine effectiveness were noted with the delta variant as compared with the alpha variant after the receipt of two vaccine doses. Absolute differences in vaccine effectiveness were more marked after the receipt of the first dose. This finding would support efforts to maximize vaccine uptake with two doses among vulnerable populations. (Funded by Public Health England.).
  • Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2. [Journal Article]
    Science. 2021 Jul 20 [Online ahead of print]Drayman N, DeMarco JK, … Tay S
  • There is an urgent need for antiviral agents that treat SARS-CoV-2 infection. We screened a library of 1,900 clinically safe drugs against OC43, a human beta-coronavirus that causes the common cold and evaluated the top hits against SARS-CoV-2. Twenty drugs significantly inhibited replication of both viruses in vitro. Eight of these drugs inhibited the activity of the SARS-CoV-2 main protease, 3C…
  • Medical Debt in the US, 2009-2020. [Journal Article]
    JAMA. 2021 07 20; 326(3):250-256.Kluender R, Mahoney N, … Yin W
  • CONCLUSIONS: This study provides an estimate of the amount of medical debt in collections in the US based on consumer credit reports from January 2009 to June 2020, reflecting care delivered prior to the COVID-19 pandemic, and suggests that the amount of medical debt was highest among individuals living in the South and in lower-income communities. However, further study is needed regarding debt related to COVID-19.
  • Estimating global and regional disruptions to routine childhood vaccine coverage during the COVID-19 pandemic in 2020: a modelling study. [Journal Article]
    Lancet. 2021 Jul 14 [Online ahead of print]Causey K, Fullman N, … Mosser JF
  • CONCLUSIONS: Routine immunisation services faced stark challenges in 2020, with the COVID-19 pandemic causing the most widespread and largest global disruption in recent history. Although the latest coverage trajectories point towards recovery in some regions, a combination of lagging catch-up immunisation services, continued SARS-CoV-2 transmission, and persistent gaps in vaccine coverage before the pandemic still left millions of children under-vaccinated or unvaccinated against preventable diseases at the end of 2020, and these gaps are likely to extend throughout 2021. Strengthening routine immunisation data systems and efforts to target resources and outreach will be essential to minimise the risk of vaccine-preventable disease outbreaks, reach children who missed routine vaccine doses during the pandemic, and accelerate progress towards higher and more equitable vaccination coverage over the next decade.
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