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((Chloroquine OR Hydroxychloroquine) AND ("Novel Coronavirus" OR COVID-19 OR SARS-CoV-2 OR 2019-nCoV) AND Journal Article[PT] NOT (Review[PT] OR Letter[PT]))
1,626 results
  • COVID-19: a basic approach to understanding potential treatments. [Journal Article]
    Gac Med Mex. 2020; 156(6):570-575.Cedillo-Alvarez C, Gallardo-Ortiz IA, … Páez-Martínez N
  • SARS-CoV-2 virus has been identified as the causative agent of the COVID-19 pandemic. Even when no standard treatment is available, antivirals such as remdesivir and other drugs such as chloroquine and ivermectin, which interfere with viral replication, have been assayed. Some strategies aimed at reducing immune mechanisms, such as the use of tocilizumab and natural antioxidants, have also been t…
  • Toxicity of hydroxychloroquine, a potential treatment for COVID-19, on free-living marine nematodes. [Journal Article]
    Mar Pollut Bull. 2021 Apr 15; 167:112361.Ben Ali M, Hedfi A, … Boufahja F
  • On March 2020, hydroxychloroquine (HCQ) was recommended as a treatment for COVID-19 high risk patients. Following the massive and widespread use of HCQ worldwide, a discernible high quantity is anticipated to end-up through the sewage systems in marine coastal areas. A closed microcosm study was undertaken herein for 30 days where meiobenthic nematodes were exposed to a range of HCQ concentration…
  • New Trends On Biological Activities And Clinical Studies Of Quinolinic Analogues: A Review. [Journal Article]
    Curr Drug Targets. 2021 Apr 14 [Online ahead of print]da Silva SEB, da Silva Moura JA, … da Rocha Pitta MG
  • The quinolinic ring, present in several molecules, has a great diversity of biological activities. Therefore, this ring is in the structure composition of several candidates of drugs in preclinical and clinical studies, thus, it is necessary the grouping of these results to facilitate the design of new drugs. For this reason, some of the activities were selected for this review, such as: antimala…
  • Clinical characteristics and outcome of COVID-19 in patients with rheumatic diseases. [Journal Article]
    Rheumatol Int. 2021 Apr 15 [Online ahead of print]Alzahrani ZA, Alghamdi KA, Almaqati AS
  • This study aimed to assess the baseline characteristics and clinical outcomes of coronavirus disease 2019 (COVID-19) in patients with rheumatic diseases and identify the risk factors associated with severe COVID-19 pneumonia. This was a retrospective study in a tertiary care center conducted through the period between March 2020 and November 2020 and included all adult patients with rheumatic dis…
  • Declining Intensive Care Unit Mortality of COVID-19: A Multi-Center Study. [Journal Article]
    J Clin Med Res. 2021 Mar; 13(3):184-190.Roomi S, Shah SO, … Jallo J
  • CONCLUSIONS: The mortality of patients admitted to our ICU system significantly decreased over time. Factors that may have contributed to this may be the result of a better understanding of COVID-19 pathophysiology and treatments. Further research is needed to elucidate the factors contributing to a reduction in the mortality rate for this patient population.
  • Role of interferon therapy in severe COVID-19: the COVIFERON randomized controlled trial. [Journal Article]
    Sci Rep. 2021 04 13; 11(1):8059.Alavi Darazam I, Shokouhi S, … Khoshkar A
  • Type 1 Interferons (IFNs) have been associated with positive effects on Coronaviruses. Previous studies point towards the superior potency of IFNβ compared to IFNα against viral infections. We conducted a three-armed, individually-randomized, open-label, controlled trial of IFNβ1a and IFNβ1b, comparing them against each other and a control group. Patients were randomly assigned in a 1:1:1 ratio t…
  • A call to caution when hydroxychloroquine is given to elderly COVID-19 patients. [Journal Article]
    Int J Infect Dis. 2021 Apr 10 [Online ahead of print]Gabor JJ, Kreidenweiss A, … Kremsner PG
  • CONCLUSIONS: The majority of hospitalized COVID-19 patients had health conditions or took co-medications precluding safe treatment with hydroxychloroquine. Therefore, especially in elderly, hydroxychloroquine should be administered with extreme caution and only in clinical trials.
  • COVID-19 pneumonia successfully managed with high-flow nasal cannula in a 15-year-old boy. [Case Reports]
    BMJ Case Rep. 2021 Apr 12; 14(4)van Gorp G, Sanders P, … Engel M
  • We report an otherwise healthy, fully immunised 15-year-old boy who was transferred to our Pediatric intensive care unit with 4 days of fever, dry cough, increased work of breathing and impending respiratory failure. Two days prior, amoxicillin/clavulanic acid was prescribed for lower airway symptoms resembling pneumonia. PCR of the nasopharyngeal swab revealed an active COVID-19 infection (Ct 19…
  • Clinical Features and Prognostic Factors of 245 Portuguese Patients Hospitalized With COVID-19. [Journal Article]
    Cureus. 2021 Mar 04; 13(3):e13687.Salvador P, Oliveira P, … Malheiro L
  • Introduction Since the declaration of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in March 2020, Portugal was considered a role model with regards to the first COVID-19 wave. However, a third wave started in 2021 started, turning the country into the worst in the world regarding new infections and death rate per capita in the last weeks of January 2021. No significan…
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