Download the Free Prime PubMed App to your smartphone or tablet.

Available for iPhone or iPad:

Unbound PubMed app for iOS iPhone iPadAlso Available:
Unbound PubMed app for Android

Available for Mac and Windows Desktops and laptops:

Unbound PubMed app for Windows
49,475 results
  • Mass balance and metabolite profiling of 14C-guadecitabine in patients with advanced cancer. [Journal Article]
    Invest New Drugs 2019Roosendaal J, Rosing H, … Oganesian A
  • Purpose The objective of this mass balance trial was to determine the excretory pathways and metabolic profile of the novel anticancer agent guadecitabine in humans after administration of a 14C-radiolabeled dose of guadecitabine. Experimental design Included patients received at least one cycle of 45 mg/m2 guadecitabine subcutaneously as once-daily doses on Days 1 to 5 of a 28-day cycle, of whic…
  • Processing Induced Degradation Routes of Prochloraz in Rapeseed Oil. [Journal Article]
    J Agric Food Chem 2019Goeckener B, Kotthoff M, … Buecking M
  • Analysing the fate of substances in complex matrices, such as processed food, is a major challenge in modern analytical chemistry. However, current regulatory procedures for pesticides only include high temperature hydrolysis of the active substance in water (OECD 507) to simulate food processing. This study shows that heating radiolabelled [imidazolyl 2 14C]prochloraz in virgin rapeseed oil at t…
  • Novel pyridazinone derivatives as butyrylcholinesterase inhibitors. [Journal Article]
    Bioorg Chem 2019; 92:103304Dundar Y, Kuyrukcu O, … Orhan IE
  • In the current study, forty-four new [3-(2/3/4-methoxyphenyl)-6-oxopyridazin-1(6H)-yl]methyl carbamate derivatives were synthesized and evaluated for their ability to inhibit electric eel acetylcholinesterase (EeAChE) and equine butyrylcholinesterase (eqBuChE) enzymes. According to the inhibitory activity results, [3-(2-methoxyphenyl)-6-oxopyridazin-1(6H)-yl]methyl heptylcarbamate (16c, eqBuChE, …
  • Fractionated Antioxidant and Anti-inflammatory Kernel Oil from Torreya fargesii. [Journal Article]
    Molecules 2019; 24(18)Zhou X, Shang J, … Zhang Y
  • Polymethylene-interrupted polyunsaturated fatty acids (PMI-PUFAs) are emerging functional lipids with proven antioxidant and anti-inflammatory effects. In this study, a typical PMI-PUFA, sciadonic acid (C20:3, 5c 11c 14c), was enriched in the kernel oil of Torreya fargesii (T. fargesii) by fractionation. Fractionated kernel oil of T. fargesii (containing 25% sciadonic acid) showed equal stability…
  • Metabolomic profiling of oxalate-degrading probiotic Lactobacillus acidophilus and Lactobacillus gasseri. [Journal Article]
    PLoS One 2019; 14(9):e0222393Chamberlain CA, Hatch M, Garrett TJ
  • Oxalate, a ubiquitous compound in many plant-based foods, is absorbed through the intestine and precipitates with calcium in the kidneys to form stones. Over 80% of diagnosed kidney stones are found to be calcium oxalate. People who form these stones often experience a high rate of recurrence and treatment options remain limited despite decades of dedicated research. Recently, the intestinal micr…
    J Mol Endocrinol 2019Vaughan O, Powell T, Jansson T
  • Excess maternal glucocorticoids reduce placental amino acid transport and fetal growth, but whether these effects are mediated directly on the syncytiotrophoblast remains unknown. We hypothesised that glucocorticoids inhibit mechanistic target of rapamycin (mTOR) signaling and insulin-stimulated System A amino acid transport activity in primary human trophoblast (PHT) cells. Syncytialised PHTs, i…
New Search Next