- Low lymphocyte-to-monocyte ratio, calcitriol level, and CD206 level predict the development of acute-on-chronic liver failure in patients with cirrhosis with acute decompensation. [Journal Article]J Chin Med Assoc. 2023 Jan 23 [Online ahead of print]JC
- CONCLUSIONS: Single and combined immunological markers, including low LMR and low levels of calcitriol and CD206, were promising for early prediction of the development of ACLF, HE, and infection in patients with cirrhosis.
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- Calcipotriol Attenuates Form Deprivation Myopia Through a Signaling Pathway Parallel to TGF-β2-Induced Increases in Collagen Expression. [Journal Article]Invest Ophthalmol Vis Sci. 2023 Feb 01; 64(2):2.IO
- CONCLUSIONS: Scleral vitamin D3 inhibits myopia development in mice, potentially by activating a VDR-dependent signaling pathway and increasing scleral COL1A1 expression levels.
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- Hungry bone syndrome after parathyroid surgery. [Journal Article]Hemodial Int. 2023 Jan 31 [Online ahead of print]HI
- CONCLUSIONS: Hungry bone syndrome is common (83.3%) after parathyroidectomy for secondary hyperparathyroidism in patients undergoing hemodialysis, and this complication should be monitored and managed appropriately.
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- Does the VDR gene polymorphism influence the efficacy of denosumab therapy in postmenopausal osteoporosis? [Journal Article]
- CONCLUSIONS: BB and Bb genotypes of the Bsml polymorphism of the VDR gene determine higher DXA parameter values both before and after one-year denosumab therapy in postmenopausal women with osteoporosis.
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- Vitamin D receptor polymorphism and prostate cancer prognosis. [Journal Article]
- CONCLUSIONS: The VDR ApaI C/A polymorphism may be a diagnostic and prognostic marker for prostate cancer in Egyptian men.
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- Vitamin D and cathelicidin levels and susceptibility to Mycobacterium tuberculosis infection acquisition in household contacts. [Journal Article]Enferm Infecc Microbiol Clin (Engl Ed). 2023 Jan 25 [Online ahead of print]EI
- CONCLUSIONS: These data argue against a major role for hypovitaminosis D in tuberculosis infection susceptibility.
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- Mechanisms of action of vitamin D in delaying aging and preventing disease by inhibiting oxidative stress. [Journal Article]Vitam Horm. 2023; 121:293-318.VH
- Although several recent studies have shown that vitamin D supplementation beneficially decreases oxidative stress parameters, there is no consensus on this subject in humans. Thus the role of vitamin D supplementation has recently become a controversial topic because large intervention studies in humans have not shown significant benefits. These studies have indicated that supplementation with pr…
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- Genotypic Spectrum and its Correlation with Alopecia and Clinical Response in Hereditary Vitamin D Resistant Rickets: Our Experience and Systematic Review. [Journal Article]Calcif Tissue Int. 2023 Jan 27 [Online ahead of print]CT
- Alopecia in hereditary vitamin D resistant rickets (HVDRR) has some correlation with severe rickets and poor overall response. However, these observations are based on small series. Hence, we aim to assess the genotypic spectrum of HVDRR and its correlation with alopecia and clinical response. Seven genetically-proven HVDDR patients from five unrelated families and 119 probands from systematic re…
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- Effect of calcitriol treated mesenchymal stem cells as an immunomodulation micro-environment on allergic asthma in a mouse model. [Journal Article]Endocr Metab Immune Disord Drug Targets. 2023 Jan 27 [Online ahead of print]EM
- CONCLUSIONS: Using the allergic asthma model, we were able to show that calcitriol-treated MSCs had an inhibitory impact on airway inflammation. Our findings suggest that the injection of calcitriol-treated MSCs may be a viable treatment option for allergic asthma.
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- IARS2-related disease manifesting as sideroblastic anemia and hypoparathyroidism: A case report. [Case Reports]
- CONCLUSIONS: Our findings broaden the clinical and genetic spectrum of IARS2-associated disease, and case summaries help raise clinical awareness of IARS2-associated disease and reduce under- and misdiagnosis.
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- Calcitriol-enhanced autophagy in gingival epithelium attenuates periodontal inflammation in rats with type 2 diabetes mellitus. [Journal Article]
- Type 2 diabetes mellitus (T2DM)-associated periodontitis is a common disease with high prevalence, associated with persistent infection and complicated manifestations. Calcitriol (1 alpha, 25-dihydroxyvitamin D3, 1,25D) is the active form of vitamin D that plays a protective role in immune regulation, bone metabolism, and inflammatory response. In this study, we constructed a T2DM model in rats b…
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- The effect of high-dose vitamin D supplementation on hepcidin-25 and erythropoiesis in patients with chronic kidney disease. [Randomized Controlled Trial]
- CONCLUSIONS: High-dose VD supplementation had no discernible effect on markers of hepcidin or erythropoiesis in the entire study cohort. However, in patients with low baseline 25(OH)D levels, high-dose VD supplementation associated with beneficial effects on erythropoiesis and iron availability. In contrast, in patients with elevated baseline 25(OH)D levels, high-dose VD supplementation resulted in a decrease in hepcidin levels, most likely due to a deterioration in iron status.
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- Dissociation of clinical, laboratory, and bone biopsy findings in adult X-linked hypophosphatemia: a case report. [Journal Article]Wien Med Wochenschr. 2023 Jan 25 [Online ahead of print]WM
- X‑linked hypophosphatemia (XLH) is a phosphate wasting disorder. Typical serum constellations include low serum phosphate as well as high alkaline phosphatase (ALP) and fibroblast growth factor 23 (FGF-23) levels. Adult XLH patients usually suffer from (pseudo)fractures, enthesopathies, impaired mobility, and osteoarthritis. We report the case of a middle-aged woman with clinically mild disease, …
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- Association between genetic variants in key vitamin-D-pathway genes and external apical root resorption linked to orthodontic treatment. [Journal Article]Eur J Oral Sci. 2023 Jan 22 [Online ahead of print]EJ
- This study evaluated the association between single-nucleotide polymorphisms (SNPs) in vitamin-D-related genes and the amount of external apical root resorption linked to orthodontic treatment. One hundred and forty-three individuals were assessed. The amount of external apical root resorption of upper central incisors (EARRinc) and lower first molars (EARRmol) were evaluated in radiographs. Seve…
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- A Parathyroid Hormone-guided Calcium and Calcitriol Supplementation Protocol Reduces Hypocalcemia-related Readmissions Following Total Thyroidectomy. [Journal Article]Endocr Pract. 2023 Jan 19 [Online ahead of print]EP
- CONCLUSIONS: Compared to a historical cohort, a PTH-guided protocol for calcium and calcitriol supplementation significantly reduces postoperative hypocalcemia and hospital readmission rates, in patients undergoing total thyroidectomy.
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- Calcitriol Suppressed Isoproterenol-induced Proliferation of Cardiac Fibroblasts via Integrin β3/FAK/Akt Pathway. [Journal Article]Curr Med Sci. 2023 Jan 21 [Online ahead of print]CM
- CONCLUSIONS: These findings revealed a novel role for CAL in suppressing the CFs growth by the downregulation of the integrin β3/FAK/Akt pathway.
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- Research Trends of Vitamin D Metabolism Gene Polymorphisms Based on a Bibliometric Investigation. [Journal Article]
- Vitamin D requires activation to show its pharmacological effect. While most studies investigate the association between vitamin D and disease, only a few focus on the impact of vitamin D metabolism gene polymorphisms (vitDMGPs). This bibliometric study aims to provide an overview of current publications on vitDMGPs (CYP27B1, CYP24A1, CYP2R1, CYP27A1, CYP2R1, DHCR7/NADSYN1), compare them across c…
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- Vitamin D Receptor Gene Polymorphisms Affect Osteoporosis-Related Traits and Response to Antiresorptive Therapy. [Journal Article]
- The present study analyzed the effect of vitamin D receptor (VDR) gene polymorphisms (ApaI, TaqI, BsmI, FokI, and Cdx2) on bone mineral density (BMD), biochemical parameters and bone turnover markers, fracture prevalence, and response to three types of antiresorptive therapy (estrogen-progesterone, raloxifene, and ibandronate) in 356 postmenopausal women from Slovakia. Association analysis reveal…
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- Chronic Hepatitis B and Related Liver Diseases Are Associated with Reduced 25-Hydroxy-Vitamin D Levels: A Systematic Review and Meta-Analysis. [Review]
- Hepatitis B infection is a major public health problem globally leading to chronic liver disease and death, which are influenced by various environmental and host factors including serum 25-hydroxy-vitamin D levels. There is no comprehensive systematic review reporting the association of serum 25-hydroxy-vitamin D levels and different stages of chronic hepatitis B. This study aimed to analyze the…
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- Systematic Review of the Treatment of Persistent Hyperparathyroidism Following Kidney Transplantation. [Review]
- Chronic kidney disease-mineral and bone disorder is one of the complications associated with chronic kidney disease. About 10-50% of patients following kidney transplantation have persistent hyperparathyroidism. Hypercalcaemic hyperparathyroidism has a negative impact on the kidney transplant outcome; therefore, it requires treatment. The data regarding the treatment of persistent hyperparathyroi…
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- Vitamin D Receptor Expression Limits the Angiogenic and Inflammatory Properties of Retinal Endothelial Cells. [Journal Article]
- The integrity of retinal endothelial cell (EC) is essential for establishing and maintaining the retinal blood barrier to ensure proper vision. Vitamin D is a hormone with known protective roles in EC function. The majority of vitamin D action is mediated through the vitamin D receptor (VDR). VDR is a nuclear receptor whose engagement by vitamin D impacts the expression of many genes with importa…
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- CorrespondenceShort shock or slow burn? Patient perspectives on treatment of actinic keratoses with 5-fluorouracil 5% cream monotherapy versus 5-fluorouracil plus calcipotriol combination therapy. [Journal Article]Clin Exp Dermatol. 2023 Jan 20; 48(1):31-32.CE
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- Calcitriol modulate post-ischemic TLR signaling pathway in ischemic stroke patients. [Journal Article]J Neuroimmunol. 2022 Dec 26; 375:578013.JN
- CONCLUSIONS: Calcitriol may be considered a protective reagent after ischemia by reducing the TLR4/NF-kB activation cascade and probably plays a beneficial role in reducing and improving ischemic stroke patients' symptoms.
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- Topical roflumilast (Zoryve) for plaque psoriasis. [Journal Article]Med Lett Drugs Ther. 2023 01 23; 65(1668):10-12.ML
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- Pembrolizumab Induced Calcitriol-Mediated Hypercalcemia. [Case Reports]
- PD-1/PD-L1 inhibitors such as pembrolizumab have radically improved the prognosis for many patients with advanced malignancies. Although revolutionary, its use can be complicated and limited by various immune-related adverse effects. Effective management depends on early recognition and prompt intervention. Herein, we describe a unique syndrome of hypercalcemia, with associated acute renal injury…
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- [The 499th case: Roux-en-Y gastric bypass, limb weakness, and ostealgia]. [Case Reports]Zhonghua Nei Ke Za Zhi. 2023 Jan 01; 62(1):117-121.ZN
- A 36-year-old woman was admitted to the Peking Union Medical College Hospital with a history of fractures for 2 years, limb weakness for 1 year, and ostealgia for 2 months. The patient's examination identified iron deficiency anemia, significantly decreased serum calcium and 25-hydroxyvitamin D3 levels, and increased alkaline phosphatase and parathyroid hormone levels. Imaging showed several typi…
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- Subtotal parathyroidectomy successfully controls calcium levels of patients with neonatal severe hyperparathyroidism carrying a novel CASR mutation. [Case Reports]Horm Res Paediatr. 2023 Jan 10 [Online ahead of print]HR
- CONCLUSIONS: We report a novel heterozygous and homozygous missense variant (c.1817T>C; p.Leu606Pro) in CASR in two NSHPT patients. The mutation likely disrupts conformational changes of CASR and results in cinacalcet unresponsiveness. Intronic variants in CASR identified in the patient with heterozygous variant might have contributed to the clinical manifestations of the patient. Although total parathyroidectomy is wildly accepted as a standard treatment for NSHPT, we demonstrate that subtotal parathyroidectomy is also an effective procedure to normalize Ca levels and allow these patients to be in normocalcemia or mild hypoparathyroidism, which is simply controlled by low-dose calcitriol treatment. Subtotal parathyroidectomy appeared to be an effective treatment for NSHPT regardless of the molecular etiologies.
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- Nutritional secondary hyperparathyroidism in a kitten, supported by immunoenzymatic measurement of feline intact parathyroid hormone. [Journal Article]J Vet Diagn Invest. 2023 Jan 10 [Online ahead of print]JV
- A 6-mo-old, intact male, domestic shorthair cat was referred with a history of poor growth, reluctance to move, and deformation of the nasal profile. The kitten had been fed a diet composed almost exclusively of a complementary pet food and tuna, which was similar to an all-meat diet. We detected osteopenia and hypocalcemia associated with severe parathyroid hormone (PTH) and calcitriol increases…
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- Active Vitamin D3 (Calcitriol) Increases Adipose Graft Retention in a Xenograft Model. [Journal Article]Aesthet Surg J. 2023 Jan 06 [Online ahead of print]AS
- CONCLUSIONS: Calcitriol increased fat graft retention in a xenograft model through. Calcitriol has potential to be a simple, economical means of increasing fat graft retention and long-term outcomes.
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