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Unbound Medicine.
(2 amino 2 deoxyglucose sulfate)
4,195 results
  • Design of an Ultralow Molecular Weight Heparin That Resists Heparanase Biodegradation. [Journal Article]
    J Med Chem. 2023 Jan 27 [Online ahead of print]Ham H, Xu Y, … Chaikof EL
  • Heparanase, an endo-β-d-glucuronidase produced by a variety of cells and tissues, cleaves the glycosidic linkage between glucuronic acid (GlcA) and a 3-O- or 6-O-sulfated glucosamine, typified by the disaccharide -[GlcA-GlcNS3S6S]-, which is found within the antithrombin-binding domain of heparan sulfate or heparin. As such, all current forms of heparin are susceptible to degradation by heparanas…
  • Hereditary Angioedema: Diagnosis, Clinical Implications, and Pathophysiology. [Review]
    Adv Ther. 2023 Jan 07 [Online ahead of print]Sinnathamby ES, Issa PP, … Kaye AD
  • Hereditary angioedema (HAE) is an autosomal dominant disorder caused by a mutation in the C1 esterase inhibitor gene. HAE affects 1/50,000 people worldwide. Three main types of HAE exist: type I, type II, and type III. Type I is characterized by a deficiency in C1-INH. C1-INH is important in the coagulation complement, contact systems, and fibrinolysis. Most HAE cases are type I. Type I and II HA…
  • Meta-analyses of sulodexide and other drugs in prevention and treatment of post-thrombotic syndrome. [Meta-Analysis]
    Eur Rev Med Pharmacol Sci. 2022 12; 26(24):9372-9381.Pompilio G, Monreal M, … Integlia D
  • CONCLUSIONS: In prevention of PTS, sulodexide and rivaroxaban showed a low incidence and reduced risk of PTS respectively, while in PTS treatment, sulodexide was significantly effective in the complete ulcers healing. These results confirm the need to move from the traditional single-pillar approach with elastic compression stockings to a more effective multi-pillar approach, tailoring the treatment to each individual patient.
  • Emerging pharmaceutical therapeutics and delivery technologies for osteoarthritis therapy. [Review]
    Front Pharmacol. 2022; 13:945876.Shentu CY, Yan G, … Peng LH
  • Osteoarthritis (OA) is one of the most common joint degenerative diseases in the world. At present, the management of OA depends on the lifestyle modification and joint replacement surgery, with the lifespan of prosthesis quite limited yet. Effective drug treatment of OA is essential. However, the current drugs, such as the non-steroidal anti-inflammatory drugs and acetaminophen, as well as gluco…
  • [Points of undenatured type II collagen application in musculoskeletal pain syndromes treatment]. [Journal Article]
    Zh Nevrol Psikhiatr Im S S Korsakova. 2022; 122(11):40-45.Shavlovskaya OA, Gromova OA, Torshin IY
  • The dominant collagen of the cartilaginous matrix in adults is type II collagen. The amount of type II collagen in the intercellular matrix of cartilage is significantly reduced against the background of musculoskeletal system diseases. The basis of articular cartilage is hyaline cartilage tissue consisting of chondrocytes with tissue-specific antigens that induce the production of antibodies in …
  • Glycosaminoglycan Analysis: Purification, Structural Profiling, and GAG-Protein Interactions. [Journal Article]
    Methods Mol Biol. 2023; 2597:159-176.Basu A, Weiss RJ
  • Glycosaminoglycans (GAGs) are long, linear polysaccharides that are ubiquitously expressed on the cell surface and in the extracellular matrix of all animal cells. These complex carbohydrates are composed of alternating glucosamine and uronic acids that can be heterogeneously N- and O-sulfated. The arrangement and orientation of the sulfated sugar residues specify the location of distinct ligand …
  • Synthesis of O-Linked Glycoconjugates in the Nervous System. [Journal Article]
    Adv Neurobiol. 2023; 29:95-116.Inokuchi JI, Go S, Hirabayashi Y
  • Glycoproteins carrying O-linked N-acetylgalactosamine, N-acetylglucosamine, mannose, fucose, glucose, and xylose are found in the nervous system. Lipids are glycosylated by distinct glycosylation enzymes as well. Membrane lipid, ceramide, is modified by the addition of either glucose or galactose to form glycosphingolipid, galactosylceramide, or glucosylceramide. Recent careful analyses by MS hav…
  • Jellyfish Polysaccharides for Wound Healing Applications. [Journal Article]
    Int J Mol Sci. 2022 Sep 29; 23(19)Migone C, Scacciati N, … Piras AM
  • Jellyfishes are considered a new potential resource in food, pharmaceutical and biomedical industries. In these latter cases, they are studied as source of active principles but are also exploited to produce marine collagen. In the present work, jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features were extracted from Rhizostoma pulmo, a main blooming species of Mediterranean…
  • An economic evaluation of knee osteoarthritis treatments in Thailand. [Journal Article]
    Front Pharmacol. 2022; 13:926431.Luksameesate P, Tanavalee A, Taychakhoonavudh S
  • Objective: The objective of this study is to evaluate the cost-effectiveness of different knee OA care sequences compared to standard treatment reimbursed by the major health insurance payer in Thailand. Method: We used decision analytical modeling to evaluate the effect of either adding etoricoxib or crystalline glucosamine sulfate compared to standard treatment from a societal perspective over …
  • Synthesis of a Systematic 64-Membered Heparan Sulfate Tetrasaccharide Library. [Journal Article]
    Angew Chem Int Ed Engl. 2023 Jan 02; 62(1):e202211985.Baryal KN, Ramadan S, … Huang X
  • Heparan sulfate (HS) has multifaceted biological activities. To date, no libraries of HS oligosaccharides bearing systematically varied sulfation structures are available owing to the challenges in synthesizing a large number of HS oligosaccharides. To overcome the obstacles and expedite the synthesis, a divergent approach was designed, where 64 HS tetrasaccharides covering all possible structure…
  • StatPearls: Glucosamine Sulfate [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)WilliamsCarolineCBeth Israel DeaconessAmpatGeorgeGUniversity of LiverpoolBOOK
  • Glucosamine sulfate is an oral supplement used in the management and treatment of osteoarthritis. This activity outlines the indications, hypothesized action, and contraindications for glucosamine sulfate as a valuable agent in managing osteoarthritis. This activity will highlight the hypothesized mechanism of action, adverse event profile, suggested dosing, monitoring for relevant interactions, …
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