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(5′ nucleotidase)
6,477 results
  • Tumor-Selective Altered Glycosylation and Functional Attenuation of CD73 in Human Hepatocellular Carcinoma. [Journal Article]
    Hepatol Commun 2019; 3(10):1400-1414Alcedo KP, Guerrero A, … Snider NT
  • CONCLUSIONS: We provide the first detailed characterization of CD73 glycosylation in normal and tumor tissue, revealing a novel mechanism that leads to the functional suppression of CD73 in human HCC tumor cells. The present findings have translational implications for therapeutic candidate antibodies targeting cell-surface CD73 in solid tumors and small-molecule adenosine receptor agonists that are in clinical development for HCC.
  • Estrogen receptors modulate ectonucleotidases activity in hippocampal synaptosomes of male rats. [Journal Article]
    Neurosci Lett 2019; 712:134474Mitrović N, Dragić M, … Grković I
  • Extracellular adenine nucleotides and nucleosides, such as adenosine-5'-triphosphate (ATP) and adenosine, are among least investigated signaling factors that participate in 17β-estradiol (E2)-mediated synaptic rearrangements in rodent hippocampus. Their levels in the extrasynaptic space are tightly controlled by ecto-nucleoside triphosphate diphosphohydrolases1-3 (NTPDase1-3)/ecto-5'-nucleotidase…
  • Cell type- and tissue-specific functions of ecto-5'-nucleotidase (CD73). [Journal Article]
    Am J Physiol Cell Physiol 2019Minor M, Alcedo KP, … Snider NT
  • CD73 is a ubiquitously-expressed glycosylphosphatidylinositol (GPI)-anchored glycoprotein that converts extracellular adenosine 5'-monophosphate (AMP) to adenosine. Anti-CD73 inhibitory antibodies are currently undergoing clinical testing for cancer immunotherapy. However, CD73 has many protective physiological functions that need to be taken into account for new targeted therapies. This review c…
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