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18,621 results
  • Climate, Life Form and Family Jointly Control Variation of Leaf Traits. [Journal Article]
    Plants (Basel) 2019; 8(8)Zhang H, Zeng Z, … Zeng F
  • Variation in leaf traits may represent differences in physiological processes and environmental adaptative strategies. Using multivariate analyses, we investigated 13 leaf traits to quantify the trade-off in these traits and the trait-climate/biome relationships based on the China Plant Trait Database, which contains morphometric and physiological character information on 1215 species for 122 sit…
  • Centre of mass control is reduced in older people when descending stairs at an increased riser height. [Journal Article]
    Gait Posture 2019; 73:305-314Foster RJ, Maganaris CN, … Buckley JG
  • CONCLUSIONS: Descending stairs became more challenging in both age groups as riser-height increased. Older adults adopted a strategy of reducing CoM velocity to lessen the eccentric landing demands. In both groups, but more so older adults, there was a greater reliance on using leading-limb eccentric plantarflexion at 255 mm riser-height compared to 170 mm, to arrest/control increased downward CoM velocity and acceleration during landing.
  • Discovery of a novel rhein-SAHA hybrid as a multi-targeted anti-glioblastoma drug. [Journal Article]
    Invest New Drugs 2019Chen J, Luo B, … Pi R
  • Glioblastoma multiforme (GBM) is the most common malignant tumor of the central nervous system (CNS). Effective treatments remain limited. Therefore, novel chemotherapy drugs with high efficiency and few adverse effects are urgently needed. Histone deacetylase (HDAC) and serum and glucocorticoid-regulated protein kinase 1 (SGK1) are targets for the prevention and treatment of GBM. Rhein has antit…
  • Application of Highly Immunocompromised Mice for the Establishment of Patient-Derived Xenograft (PDX) Models. [Review]
    Cells 2019; 8(8)Okada S, Vaeteewoottacharn K, Kariya R
  • Patient-derived xenograft (PDX) models are created by engraftment of patient tumor tissues into immunocompetent mice. Since a PDX model retains the characteristics of the primary patient tumor including gene expression profiles and drug responses, it has become the most reliable in vivo human cancer model. The engraftment rate increases with the introduction of Non-obese diabetic Severe combined …
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