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65,196 results
  • Cortisol response in children with cancer and fever during chemotherapy: A prospective, observational study using random serum cortisol levels. [Journal Article]
    Cancer Med. 2023 Feb 03 [Online ahead of print]Boekstegers A, Schmidt H, … Schmid I
  • CONCLUSIONS: The incidence of an impaired HPA axis in pediatric cancer patients might be underestimated since 69% of the children in our study had a LCR during fever. Intake of dexamethasone, posaconazole and a time period of ≤7 days from the last glucocorticoid intake were additional risk factors for an LCR. However, we could not confirm that patients with a LCR fared worse than patients with a high cortisol response (HCR). Therefore, a different cortisol threshold may be necessary for defining an impaired HPA axis in febrile oncologic patients without concomitant symptoms of AI.
  • Stress biomarkers in individuals with fibromyalgia syndrome: a systematic review with meta-analysis. [Journal Article]
    Pain. 2023 Jan 05 [Online ahead of print]Beiner E, Lucas V, … Tesarz J
  • Evidence suggests an involvement of hypothalamic-pituitary-adrenal (HPA) axis dysregulation in the development and maintenance of fibromyalgia syndrome (FMS). However, studies on the stress response via the HPA-axis in individuals with FMS show conflicting results. To better understand the relationship between FMS and HPA-axis dysregulation, we (1) systematically summarized the current level of e…
  • Intestinal tuberculosis in a patient with Cushing's syndrome. [Case Reports]
    IDCases. 2023; 31:e01674.Soriano JME, Amadore RA, … Gatchalian LB
  • A 39-year-old woman presented with cushingoid features was worked up and diagnosed to have ACTH-independent Cushing's syndrome. Computed tomography of the whole abdomen revealed a left adrenal mass. She was scheduled for elective laparoscopic left adrenalectomy, however, a few days prior to the surgery, the patient had hematochezia. Colonoscopy revealed multiple ulcers on the terminal ileum, to w…
  • Patterns of stress response to foreign eggs by a rejecter host of an obligate avian brood parasite. [Journal Article]
    Ecol Evol. 2023 Jan; 13(1):e9691.Abolins-Abols M, Peterson M, … Hauber ME
  • One of the most effective defenses of avian hosts against obligate brood parasites is the ejection of parasitic eggs from the nests. Despite the clear fitness benefits of this behavior, individuals within so-called "egg-rejecter" host species still show substantial variation in their propensity to eliminate foreign eggs from the nest. We argue that this variation can be further understood by stud…
  • Immune checkpoint inhibitor-mediated hypophysitis: no place like home. [Journal Article]
    Clin Med (Lond). 2023 Jan; 23(1):81-84.Cooksley T, Knight T, … Adam S
  • Ambulatory emergency care forms a fundamental part of the strategy of trying to ensure safe and sustainable acute care services. Immune checkpoint inhibitor(ICI)-mediated hypophysitis is an important life-threatening complication of therapy. Patients presenting with clinical features and findings consistent with ICI-mediated hypophysitis were considered in the current study. In the absence of sev…
  • ACTH-independent production of 11-oxygenated androgens and glucocorticoids in an adrenocortical adenoma. [Case Reports]
    Eur J Endocrinol. 2022 Dec 01; 187(6):K39-K45.Kitamura T, Blinder AR, … Tagami T
  • Due to its rarity, biochemical and histologic characteristics of androgen and glucocorticoid co-secreting adrenocortical adenomas are largely unknown. Herein, we report a case of adrenocortical adenoma that caused marked hyperandrogenemia and mild autonomous cortisol secretion. In this study, we investigated serum steroid profiles using liquid chromatography-tandem mass spectrometry (LC-MS/MS) an…
  • [Steroid profiling characteristics in pediatrc adrenal diseases]. [Journal Article]
    Probl Endokrinol (Mosk). 2022 Nov 03; 68(6):110-120.Yanar EA, Makazan NV, … Peterkova VA
  • CONCLUSIONS: Results of our study steroid profiling can be used as additional differential diagnosis method in patients with adrenocortical adenomas with or without hormonal hyperproduction (ACTH-independent Cushing syndrome and incidentaloma). Further studies are needed to identify steroid markers for subtyping pediatric adrenal diseases.
  • [Survival predictors in patients with ectopic acth syndrome]. [Journal Article]
    Probl Endokrinol (Mosk). 2022 Aug 15; 68(6):30-42.Golounina OO, Belaya ZE, … Dedov II
  • CONCLUSIONS: The prognosis of patients with EAS is influenced by the age of diagnosis, NET localization, distant metastases and level of LNSC. The most common cause of ectopic ACTH syndrome was bronchopulmonary NET which was associated with the best survival rate.
  • Multilimbed membrane guanylate cyclase signaling system, evolutionary ladder. [Review]
    Front Mol Neurosci. 2022; 15:1022771.Duda T, Sharma RK
  • One monumental discovery in the field of cell biology is the establishment of the membrane guanylate cyclase signal transduction system. Decoding its fundamental, molecular, biochemical, and genetic features revolutionized the processes of developing therapies for diseases of endocrinology, cardio-vasculature, and sensory neurons; lastly, it has started to leave its imprints with the atmospheric …
  • High fat diet exacerbates stress responsivity in juvenile traumatic brain injury. [Journal Article]
    J Neurotrauma. 2023 Jan 21 [Online ahead of print]Smith AM, Warfield ZJ, … Grayson BE
  • Traumatic brain injury (TBI) is one of the leading causes of death for children in the United States. Juveniles are more likely to sustain TBIs than most other age groups, and TBI has been shown to result in increased anxiety and stress behaviors. In addition, the hypothalamic-pituitary-adrenal (HPA) axis has previously been shown to become dysregulated after a TBI. Furthermore, many children con…
  • An Approach to Traumatic Brain Injury-Related Hypopituitarism: Overcoming the Pediatric Challenges. [Case Reports]
    Diagnostics (Basel). 2023 Jan 06; 13(2)Vlad RM, Albu AI, … Păcurar D
  • Traumatic brain injury (TBI)-related hypopituitarism is a rare polymorphic complication of brain injury, with very little data, particularly concerning children and teenagers. This is a comprehensive review of the literature regarding this pathology, starting from a new pediatric case. The research was conducted on PubMed and included publications from the last 22 years. We identified nine origin…
  • Advances in Molecular Pathophysiology and Targeted Therapy for Cushing's Disease. [Review]
    Cancers (Basel). 2023 Jan 13; 15(2)Takayasu S, Kageyama K, Daimon M
  • Cushing's disease is caused by autonomous secretion of adrenocorticotropic hormone (ACTH) from corticotroph pituitary neuroendocrine tumors. As a result, excess cortisol production leads to the overt manifestation of the clinical features of Cushing's syndrome. Severe complications have been reported in patients with Cushing's disease, including hypertension, menstrual disorders, hyperglycemia, o…
  • Glucocorticoid-sensitive period of corticotroph development-Implications for mechanisms of early life stress. [Journal Article]
    J Neuroendocrinol. 2022 Dec 27 [Online ahead of print]Peles G, Swaminathan A, Levkowitz G
  • Corticotrophs are intermediaries in the hypothalamic-pituitary-adrenal (HPA) axis, which plays a crucial role in stress response in vertebrates. The HPA axis displays an intricate mode of negative feedback regulation, whereby the peripheral effector, cortisol inhibits the secretion of its upstream regulator, adrenocorticotropic hormone (ACTH) from proopiomelanocortin (POMC)-expressing cells in th…
  • Gene Mutations in Cushing's Syndrome. [Review]
    Mol Syndromol. 2023 Jan; 13(6):459-470.Ojha U, Ogunmwonyi I, … Ojha H
  • Prolonged exposure to glucocorticoids can result in the development of Cushing's syndrome. Excess serum cortisol can occur due to several factors including exogenous steroids, pituitary and adrenal adenoma, and ectopic ACTH secretion.
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