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(ACTH)
61,236 results
  • Developing an optimal follow-up strategy based on the natural history of nonfunctioning pituitary adenomas. [Journal Article]
  • JNJ Neurosurg 2018 Sep 14; :1-7
  • Kim JH, Dho YS, … Shin CS
  • CONCLUSIONS: The authors have devised a follow-up strategy based on the tumor volume growth rate as well as initial tumor volume. In patients with microadenomas, the next MRI study can be performed at 3 years. In patients with macroadenomas, the second MRI study should be performed between 6 months and 1 year to assess the tumor growth rate. In patients with a tumor growth rate ≥ 0.88 cm3/year, the MRI study should be performed within 2 years. In patients with a tumor growth rate < 0.88 cm3/year, the MRI study can be delayed until 4 years.
  • Adrenocortical function during prolonged critical illness and beyond: a prospective observational study. [Journal Article]
  • ICIntensive Care Med 2018 Sep 13
  • Peeters B, Meersseman P, … Van den Berghe G
  • CONCLUSIONS: Irrespective of sepsis/septic shock, need for glucocorticoids and survival, low cortisol plasma binding proteins and suppressed cortisol breakdown determine systemic (free)cortisol availability in prolonged critical illness, the latter no longer elevated beyond ICU day 28. The uniform rise in ACTH and cortisol to supra-normal levels 1 week after ICU discharge indicates recovery of a central adrenocortical suppression while in ICU. Low cortisol plasma binding invalidates the cosyntropin test.
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