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137,786 results
  • Deleterious mtDNA Mutations are Common in Mature Oocytes. [Journal Article]
    Biol Reprod 2019Ma H, Hayama T, … Mitalipov S
  • Heritable mitochondrial DNA (mtDNA) mutations are common, yet only a few recurring pathogenic mtDNA variants account for the majority of known familial cases in humans. Purifying selection in the female germline is thought to be responsible for the elimination of most harmful mtDNA mutations during oogenesis. Here, we show that deleterious mtDNA mutations are abundant in ovulated mature mouse ooc…
  • Coenzyme Q10 supplementation acts as antioxidant on dystrophic muscle cells. [Journal Article]
    Cell Stress Chaperones 2019Mizobuti DS, Fogaça AR, … Minatel E
  • Increased oxidative stress is a frequent feature in Duchenne muscular dystrophy (DMD). High reactive oxygen species (ROS) levels, associated with altered enzyme antioxidant activity, have been reported in dystrophic patients and mdx mice, an experimental model of DMD. In this study, we investigated the effects of coenzyme Q10 (CoQ10) on oxidative stress marker levels and calcium concentration in …
  • Different platinum crystal surfaces show very distinct protein denaturation capabilities. [Journal Article]
    Nanoscale 2019Liu S, Yin X, … Zhou R
  • Different platinum (Pt) surfaces of nanocrystals usually exhibit significant distinctions with regard to various biological, physical, and chemical characteristics, such as bio-recognition, surface wetting, and catalytic activities. In this study, we report for the first time that two shape-controlled Pt nanocrystals with the most common low-index surfaces, Pt(100) and Pt(111), show very dissimil…
  • Rapid laser solver for the phase retrieval problem. [Journal Article]
    Sci Adv 2019; 5(10):eaax4530Tradonsky C, Gershenzon I, … Davidson N
  • Tailored physical systems were recently exploited to rapidly solve hard computational challenges, such as spin simulators, combinatorial optimization, and focusing through scattering media. Here, we address the phase retrieval problem where an object is reconstructed from its scattered intensity distribution. This is a key problem in many applications, ranging from x-ray imaging to astrophysics, …
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