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11,637 results
  • Cadmium and High-Fat Diet Disrupt Renal, Cardiac and Hepatic Essential Metals. [Journal Article]
    Sci Rep 2019; 9(1):14675Young JL, Yan X, … Freedman JH
  • Exposure to the environmental toxicant cadmium (Cd) contributes to the development of obesity-associated diseases. Obesity is a risk factor for a spectrum of unhealthy conditions including systemic metabolic dyshomeostasis. In the present study, the effects of whole-life exposure to environmentally-relevant concentrations of Cd on systemic essential metal distribution in adult mice fed a high-fat…
  • Below the Surface: IGF-1R Therapeutic Targeting and Its Endocytic Journey. [Review]
    Cells 2019; 8(10)Crudden C, Song D, … Girnita L
  • Ligand-activated plasma membrane receptors follow pathways of endocytosis through the endosomal sorting apparatus. Receptors cluster in clathrin-coated pits that bud inwards and enter the cell as clathrin-coated vesicles. These vesicles travel through the acidic endosome whereby receptors and ligands are sorted to be either recycled or degraded. The traditional paradigm postulated that the endocy…
  • MANAGEMENT OF ENDOCRINE DISEASE: Are all GLP-1 agonist equal in the treatment of type 2 diabetes? [Review]
    Eur J Endocrinol 2019Nauck MA, Meier JJ
  • GLP-1, a peptide hormone secreted from the gut stimulating insulin and suppressing glucagon secretion was identified as a parent compound for novel treatments of diabetes, but was degraded (dipeptidyl peptidase-4) eliminated (mainly kidneys) too fast (half-life 1-2 min) to be useful as a therapeutic agent. GLP-1 receptor agonist have been used to treat patients with type 2 diabetes since 2007, wh…
  • Tuberculosis in Systemic Lupus Erythematosus Patients. [Journal Article]
    Mymensingh Med J 2019; 28(4):797-807Ahmmed MF, Islam MN, … Ferdous N
  • The tubercular infections (TB) are most important cause of morbidity and mortality in SLE patients worldwide and an ongoing alarming issue in developing countries. This observational study was carried out in SLE clinic of BSMMU, Bangladesh from April 2015 to March 2016 after taking ethical clearance from IRB to observe frequency and risk factors of tuberculosis in SLE patients. A total 230 consec…
  • Detection of Tubercular Pleural Effusion by Molecular Technique PCR. [Journal Article]
    Mymensingh Med J 2019; 28(4):721-726Islam A, Hossain MA, … Islam A
  • Tuberculosis is a common cause of death in developing countries like Bangladesh. About 30% of pulmonary tubercular infected patients developed tubercular pleural effusion. Tubercular pleural effusion was diagnosed by cytological, biochemical and bacteriological methods. But these methods showed low sensitivity. In some cases pleural biopsy showed also negative results. Now a days molecular techni…
  • Two dimensional diffusion-controlled triplet-triplet annihilation kinetics. [Journal Article]
    Chem Sci 2019; 10(32):7633-7640Gschwend GC, Kazmierczak M, … Girault HH
  • Diffusion controlled chemical reactions are usually observed in three dimensional media. In contrast, planar bimolecular reactions taking place between reagents adsorbed at a soft interface are two-dimensional and therefore cannot be studied within the same formalism. Indeed, soft interfaces allow the adsorbed species to freely diffuse in a liquid-like manner. Here, we present the first experimen…
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