- Intractable hyponatremia complicated by a reset osmostat: a case report. [Case Reports]
- CONCLUSIONS: Preservation of urinary concentrating and diluting ability at a lower-than-normal serum sodium concentration, especially in the setting of chronic hyponatremia, is diagnostic of a reset osmostat. The presence of a reset osmostat often confounds the treatment of concomitant acute hyponatremia. Early recognition of a reset osmostat avoids the need to normalize serum sodium concentration, expedites hospital discharge, and limits potential harm from overcorrecting acute hyponatremia.
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- Ratio Profile: Physiologic Approach to Estimating Appropriate Intravenous Fluid Rate to Manage Hyponatremia in the Syndrome of Inappropriate Antidiuresis. [Review]
- A hyponatremic patient with the syndrome of inappropriate antidiuresis (SIAD) gets normal saline (NS), and the plasma sodium decreases, paradoxically. To explain, desalination is often invoked: if urine is more concentrated than NS, the fluid's salts are excreted while some water is reabsorbed, exacerbating hyponatremia. But comparing concentrations can be deceiving. They should be converted to q…
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- Endotext: Endocrine testing for the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) [BOOK]Endotext. MDText.com, Inc.: South Dartmouth (MA)BOOK
- The diagnosis of Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) relies on an adequate assessment of a hyponatremic state (that is a serum sodium level <136 mmol/l) and on the exclusion of other causative conditions leading to an adequate secretion of antidiuretic hormone (ADH). The understanding of mechanisms involved in pathological ADH secretion is essential for diagnosis and …
- Efficacy of empagliflozin for syndrome of inappropriate antidiuresis. [Journal Article]Nat Rev Nephrol. 2023 Feb; 19(2):73.NR
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- Hyponatremia and stroke mimic: a case report. [Case Reports]
- The differential diagnosis of acute stroke is often a challenge for the emergency care staff. In medical literature, about 30% of patients presenting in an emergency department with suspected stroke at initial assessment are actually stroke mimic. We report here a case of a 61-year-old woman who got admitted at the emergency service for an acute stroke that was actually a symptomatic hyponatremia…
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- Vaptans for hyponatraemia. [Letter]Br J Clin Pharmacol. 2023 Feb; 89(2):921.BJ
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- Human herpesvirus 6 (HHV-6) associated permanent hyponatremia in umbilical cord blood transplant recipient. [Case Reports]Transpl Immunol. 2023 Feb; 76:101742.TI
- Long-term neurocognitive deficits after human herpesvirus-6 (HHV-6) infection are common in stem-cell transplant recipients, but SIADH (Syndrome of inappropriate antidiuretic hormone secretion) with persistent hyponatremia is rare. A 51-year-old woman presented with somnolence, hyponatremia (121 mmol/L) and HHV-6 viremia (80,330 copies/ml) on day +22 post umbilical cord blood transplant (UCBT). W…
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- Disorders of Salt and Water Balance After Pituitary Surgery. [Journal Article]
- Transsphenoidal surgery is the first-line treatment for many clinically significant pituitary tumors and sellar lesions. Although complication rates are low when performed at high-volume centers, disorders of salt and water balance are relatively common postoperatively. Both, or either, central diabetes insipidus (recently renamed arginine vasopressin deficiency - AVP-D), caused by a deficiency i…
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- Associations of hyponatremia and SIADH with increased mortality, young age and infection parameters in patients with tuberculosis. [Journal Article]
- CONCLUSIONS: In this study of a large cohort from a tertiary care hospital in a non-endemic area of TB, 0.07% of patients presenting with hyponatremia, but especially younger patients and patients with high CRP values, were diagnosed with TB. Crucially, patients with moderate to profound hyponatremia had a significantly higher mortality rate and thus required increased medical care.
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- Idiopathic SIADH: 4 years of diagnostic wandering. [Case Reports]
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- A case of linezolid-induced SIADH in elderly and a review of the literature. [Case Reports]Eur Rev Med Pharmacol Sci. 2022 08; 26(16):5706-5709.ER
- CONCLUSIONS: This is the fourth case of linezolid-induced SIADH. A thorough workup was essential for the diagnosis to correctly differentiate between SIADH and other causes of hyponatremia, which helped us properly conducting follow-up treatments. SIADH is a rare but serious side effect of linezolid, and practicing physicians should be aware of this complication. It is necessary to periodically monitor the serum sodium.
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- [Update on the diagnosis and management of SIADH and Diabetes insipidus]. [Journal Article]Dtsch Med Wochenschr. 2022 09; 147(17):1096-1103.DM
- Dysnatremia is a common occurrence in patients with COVID-19 and is associated with higher mortality and risk for septic conditions. The pathomechanisms are probably multifaceted, but severe hyponatremia may also occur as a result of underlying SIADH or hypocortisolism. Patients with preexisting AVP dysfunction, like SIADH or diabetes insipidus, are at high risk for severe electrolyte imbalances …
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- Hyponatremia and SARS-CoV-2 infection: A narrative review. [Review]
- A novel rapid spreading and changing virus called SARS-CoV-2 appeared in Wuhan city in December 2019. It was announced by the World Health Organization (WHO) as a pandemic disease in March 2020. It commonly presents with respiratory symptoms; however, it may be asymptomatic. Electrolyte abnormalities are not uncommon features of SARS-CoV-2 infection. Hyponatremia is one of these electrolyte distu…
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- Hyperlactatemia and other perioperative metabolic disturbances in neuroanesthesia. [Review]
- CONCLUSIONS: These findings will contribute to a better understanding of the pathophysiology involved and enable better prevention and therapy where possible in clinical practice.
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- Paraneoplastic syndromes: A focus on pathophysiology and supportive care. [Journal Article]Am J Health Syst Pharm. 2022 11 07; 79(22):1988-2000.AJ
- CONCLUSIONS: Supportive care for PNSs lends opportunities to pharmacists to add quality, value, and safety.
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- Eosinophilic granulomatosis with polyangiitis as a rare cause of the syndrome of inappropriate antidiuretic hormone secretion. [Review]
- Eosinophilic granulomatosis with polyangiitis (EGPA, Churg-Strauss syndrome) is a rare multisystem necrotizing vasculitis that involves small- to medium-sized blood vessels. We report a rare case of syndrome of the inappropriate antidiuretic hormone (ADH) secretion (SIADH) secondary to EGPA. A 53-year-old man applied with complaints of pain in the large joints and morning stiffness in knee for 2 …
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- Hyponatremia in the emergency department. [Review]Am J Emerg Med. 2022 10; 60:1-8.AJ
- Hyponatremia, defined as a serum sodium <135 mmol/L, is frequently encountered in patients presenting to the emergency department. Symptoms are often unspecific and include a recent history of falls, weakness and vertigo. Common causes of hyponatremia include diuretics, heart failure as well as Syndrome of Inappropriate Antidiuresis (SIAD) and correct diagnosis can be challenging. Emergency treat…
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- Diagnosis and Management of Hyponatremia: A Review. [Review]
- CONCLUSIONS: Hyponatremia affects approximately 5% of adults and 35% of patients who are hospitalized. Most patients should be managed by treating their underlying disease and according to whether they have hypovolemic, euvolemic, or hypervolemic hyponatremia. Urea and vaptans can be effective in managing the syndrome of inappropriate antidiuresis and hyponatremia in patients with heart failure; hypertonic saline is reserved for patients with severely symptomatic hyponatremia.
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- Symptomatic hyponatremia after ChAdOx1 nCoV-19 coronavirus disease-19 vaccination. [Case Reports]Clin Nephrol. 2022 Sep; 98(3):162-166.CN
- Adverse events, particularly severe adverse events, after coronavirus disease vaccination are the primary concern for many patients. We present the first report of symptomatic hyponatremia, a potentially life-threatening condition, after administration of the ChAdOx1 nCoV-19 coronavirus disease-19 vaccine. A 24-year-old man developed altered consciousness and high-grade fever a day after receivin…
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- StatPearls: Neurohypophysis [BOOK]StatPearls. StatPearls Publishing: Treasure Island (FL)BOOK
- The neurohypophysis (pars posterior) is a structure that is located at the base of the brain and is the posterior lobe of the pituitary gland. Its embryological origin is from the neuroectodermal layer called the infundibulum. The neurohypophysis is divided into two regions; the pars nervosa and the infundibular stalk. Sometimes the pars intermedia and the median eminence are included. It secrete…
- Asymptomatic syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following duloxetine treatment for pain with depression: Two case reports. [Case Reports]
- CONCLUSIONS: We conclude that asymptomatic SIADH was induced by use of duloxetine. Psychiatrists should be aware of this syndrome.
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- Clinical efficacy of urea treatment in syndrome of inappropriate antidiuretic hormone secretion. [Journal Article]
- The aim of this work is to examine our experience in the use of urea in patients with SIADH. Observational retrospective analysis of 48 patients with SIADH that have been treated with urea in a third-level hospital. Pre-post analysis of serum sodium levels. The 48 patients with SIADH had a median age of 78.5 (range 26-97 years). The serum sodium nadir was 119.8 ± 5.0 mmoL/L and at the beginning o…
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- Syndrome of Inappropriate Secretion of Antidiuretic Hormone Associated With Varicella Infection in Children. [Case Reports]
- A 9-year-old girl with remarkable hyponatremia was diagnosed with SIADH that was likely secondary to varicella. Under appropriate treatment, her serum sodium returned to the normal level. There was no evidence of hyponatremia at a 3-month follow-up. We propose that medical professionals need to consider the existence of that SIADH when treating patients with varicella who present with severe hypo…
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- [The role of hyponatremia in the rapid onset of coma after Cyclophosphamide]. [Case Reports]Rev Mal Respir. 2022 Jun; 39(6):571-574.RM
- CONCLUSIONS: Hyponatremia induced by low-dose Cyclophosphamide is a rare but serious adverse effect that requires special attention.
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- Syndrome of inappropriate antidiuretic hormone secretion. [Review]Med Clin (Barc). 2022 08 12; 159(3):139-146.MC
- Hyponatremia is the most frequent electrolytic disorder in hospitalized patients, and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH), the most frequent cause of hiponatremia with clinically normal extracellular volume. It consists of a disorder of the regulation of body water that obeys to different causes, mainly cancer, pulmonary illnesses, disorders of the central nerv…
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- A Tick-Borne Cause of Hyponatremia: SIADH Due to Lyme Meningitis. [Case Reports]Am J Med. 2022 10; 135(10):e389-e390.AJ
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- Syndrome of Inappropriate Antidiuretic Hormone Secretion Following Ayahuasca Use in a Satanic Ritual: A Case Report. [Case Reports]
- Ayahuasca is a psychedelic blend originating from South America that has been used for hundreds of years by local tribes in ritualistic ceremonies. For the last few decades, its usage has expanded to North America in various mindfulness retreats that can benefit from its hallucinogenic properties. In this case report, our patient had attended a satanic ritual where he had consumed copious amounts…
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- Syndrome of inappropriate antidiuretic hormone secretion is associated with different proton pump inhibitor use: a pharmacovigilance study. [Journal Article]
- CONCLUSIONS: According to our findings, more attention should be paid to SIADH within the first several months after the administration of PPIs. For women older than 65 years, dexlansoprazole may reduce the incidence of PPI-associated SIADH. Nonetheless, larger epidemiological studies are suggested to verify this conclusion.
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- Severe Hyponatremia During First Cycle of Cyclophosphamide/Doxorubicin Chemotherapy. [Journal Article]Am J Ther. 2022 May 18 [Online ahead of print]AJ
- Syndrome of inappropriate anti-diuretic hormone release (SIDAH) is a condition characterized by an unregulated release of anti-diuretic hormone (ADH) resulting in increased water retention and decreased plasma osmolarity. Without regulation, ADH release will cause a significant decrease in plasma sodium concentration and can present with cramping, nausea, vomiting, and in severe cases, seizures, …
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