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88,994 results
  • PARP Inhibition in Cancer: An Update on Clinical Development. [Review]
    Target Oncol 2019Sachdev E, Tabatabai R, … Mita MM
  • PARP (poly(ADP-ribose) polymerase) inhibitors represent a novel class of anti-cancer therapy; they take advantage of synthetic lethality and induce cell death by exploiting a defect in DNA repair. This class of medication was initially evaluated in patients with BRCA-associated tumors, but efficacy was also demonstrated in other populations. Since 2014, four PARP inhibitors have been approved in …
  • Platelet CD40 ligand and bleeding during P2Y12 inhibitor treatment in acute coronary syndrome. [Journal Article]
    Res Pract Thromb Haemost 2019; 3(4):684-694Grosdidier C, Blanz KD, … Canault M
  • Antiplatelet therapy through inhibition of the adenosine diphosphate (ADP)/P2Y12 pathway is commonly used in the treatment of acute coronary syndrome (ACS). Although efficient in preventing platelet activation and thrombus formation, it increases the risk of bleeding complications. In patients with ACS receiving platelet aggregation inhibitors, that is, P2Y12 blockers (n = 923), we investigated t…
  • Durable Antipilling Modification of Cotton Fabric with Chloropyrimidine Compounds. [Journal Article]
    Polymers (Basel) 2019; 11(10)Dong X, Xing T, Chen G
  • Cotton fabric, a natural cellulose material, is widely used in the textile industry for its excellent properties. However, its application in some fields are seriously restricted because of its poor antipilling behavior. In this study, cotton fabrics were modified with 2,4,6-trichloropyrimidine (TLP), 2,4-dichloro-5-methoxypyrimidine (DMP), and 2-amino-4,6-dichloropyridine (ADP). The surface morp…
  • Epicatechin influences primary hemostasis, coagulation and fibrinolysis. [Journal Article]
    Food Funct 2019Sinegre T, Teissandier D, … Lebreton A
  • The different stages of hemostasis (i.e., primary hemostasis, coagulation and fibrinolysis) are involved in the early atherothrombosis steps. The aim of this study was to investigate the effect of epicatechin, a major flavonoid compound, on the hemostasis phenotype using clinically relevant in vitro global assays that mimic the complexity of the in vivo hemostasis systems. Plasma samples from 10 …
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