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147 results
  • The Pseudo-Pelger HuËt Cell-A New Permanent Radiation Biomarker. [Journal Article]
    Health Phys 2017; 112(3):252-257Goans RE, Iddins CJ, … Dainiak N
  • Using archival peripheral blood slides obtained from patients in the 1958 Y-12 criticality accident, the authors have recently described the pseudo-Pelger Huët anomaly (PHA) in neutrophils as a new radiation-induced biomarker. The current work provides additional evidence that PHA is also a permanent biomarker, potentially useful in retrospective dosimetry. In the Y-12 cohort, the high dose group…
  • Establishment of Early Endpoints in Mouse Total-Body Irradiation Model. [Journal Article]
    PLoS One 2016; 11(8):e0161079Koch A, Gulani J, … Ossetrova N
  • Acute radiation sickness (ARS) following exposure to ionizing irradiation is characterized by radiation-induced multiorgan dysfunction/failure that refers to progressive dysfunction of two or more organ systems, the etiological agent being radiation damage to cells and tissues over time. Radiation sensitivity data on humans and animals has made it possible to describe the signs associated with AR…
  • MDP: A Deinococcus Mn2+-Decapeptide Complex Protects Mice from Ionizing Radiation. [Journal Article]
    PLoS One 2016; 11(8):e0160575Gupta P, Gayen M, … Maheshwari RK
  • The radioprotective capacity of a rationally-designed Mn2+-decapeptide complex (MDP), based on Mn antioxidants in the bacterium Deinococcus radiodurans, was investigated in a mouse model of radiation injury. MDP was previously reported to be extraordinarily radioprotective of proteins in the setting of vaccine development. The peptide-component (DEHGTAVMLK) of MDP applied here was selected from a…
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