- Long-term outcomes of perioperative myocardial infarction/injury after non-cardiac surgery. [Journal Article]Eur Heart J. 2023 Jan 27 [Online ahead of print]EH
- CONCLUSIONS: At 1 year, most PMI aetiologies have unacceptably high rates of MACE and all-cause death, highlighting the urgent need for more intensive treatments.
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- Trends in contemporary advanced heart failure management: an in-depth review over 30 years of heart transplant service in Hong Kong. [Journal Article]
- CONCLUSIONS: The burden of AHF management has increased and gained complexity over the past 30 years in Hong Kong.
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- Effectiveness of Yiqi Fumai lyophilized injection for acute heart failure: Rationale and design of the AUGUST-AHF cohort study. [Journal Article]
- The effect of Yiqi Fumai lyophilized injection (YQFM) on acute heart failure (AHF) patients has been evaluated in a large sample, randomized, controlled trial (AUGUST-AHF RCT study). However, restrictive eligibility criteria from a randomized clinical trial may raise concerns about the generalizability of the results to under-represented groups or complex patients with multimorbidity. Therefore, …
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- Improvement in Renal Function During the Treatment of Acute Decompensated Heart Failure: Relationship With Markers of Renal Tubular Injury and Prognostic Importance. [Journal Article]Circ Heart Fail. 2023 Jan 26 [Online ahead of print]CH
- CONCLUSIONS: IRF during decongestive therapy for acute decompensated heart failure was not associated with improved markers of renal tubular injury and was associated with worsened survival, likely driven by the presence of greater underlying cardiorenal dysfunction and more severe congestion.
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- Efficacy of tolvaptan on the short and mid-term prognosis in elderly patients with acute heart failure coexisting with oliguria: A retrospective cohort study. [Journal Article]Front Cardiovasc Med. 2022; 9:1075631.FC
- CONCLUSIONS: This study demonstrated that the addition of TLV was clinically effective in increasing urine output, and had favorable effects on alleviating AHF progression and may reduce the risk of all-cause mortality at 7 and 90-day in elderly patients with AHF with oliguria, and TLV had a good safety profile.
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- Discussion of a study on the role of EMS in prognosis of elderly patients with AHF. [Letter]Int J Cardiol. 2023 Jan 18 [Online ahead of print]IJ
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- Usefulness of High-Sensitivity Troponin I in Risk Stratification and Final Disposition of Patients with Acute Heart Failure in the Emergency Department: Comparison between HFpEF vs. HFrEF. [Journal Article]
- Background and Objectives: In patients with acute heart failure (AHF), there is no definite evidence on the relationship between high-sensitivity cardiac troponin (hs-cTnI) and the left ventricular ejection fraction (LVEF) comparing the reduced and preserved EF conditions. Materials and Methods: Between January and April 2022, we retrospectively analyzed the data from 386 patients admitted to the…
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- Involvement of Vasopressin in Tissue Hypoperfusion during Cardiogenic Shock Complicating Acute Myocardial Infarction in Rats. [Journal Article]
- Acute heart failure (AHF) due to acute myocardial infarction (AMI) is likely to involve cardiogenic shock (CS), with neuro-hormonal activation. A relationship between AHF, CS and vasopressin response is suspected. This study aimed to investigate the implication of vasopressin on hemodynamic parameters and tissue perfusion at the early phase of CS complicating AMI. Experiments were performed on ma…
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- Effect of protein underdosing on the prognosis of patients with severe acute heart failure in the early acute phase: A single-institutional retrospective cohort study. [Journal Article]Clin Nutr ESPEN. 2023 Feb; 53:260-267.CN
- CONCLUSIONS: Protein underdosing in the early acute phase of severe AHF may be associated with increased in-hospital mortality.
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- Disconnect between the effects of serelaxin on renal function and outcome in acute heart failure. [Journal Article]Clin Res Cardiol. 2023 Jan 19 [Online ahead of print]CR
- CONCLUSIONS: Despite the significant improvement in renal function by serelaxin in patients with acute HF, the potential beneficial treatment effect was not mediated by improvement in renal function. These data suggest that improvement in renal function might not be a suitable surrogate marker for potential treatment efficacy in future studies with novel relaxin agents in acute HF. Central illustration. Conceptual model explaining mediation analysis; treatment efficacy of heart failure therapies mediated by renal function.
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- Intermittent inotropic support with levosimendan in advanced heart failure as destination therapy: The LEVO-D registry. [Journal Article]ESC Heart Fail. 2023 Jan 19 [Online ahead of print]EH
- CONCLUSIONS: In this large real-life series of AHF patients treated with levosimendan as destination therapy, we show a significant decrease of heart failure events during the year after the first administration. The simple LEVO-D Score could be of help when deciding about futile therapy in this population.
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- Sex differences and disparities in cardiovascular outcomes of COVID-19. [Journal Article]Cardiovasc Res. 2023 Jan 18 [Online ahead of print]CR
- CONCLUSIONS: Women in GW were at increased risk of AHF and in-hospital mortality for COVID-19 compared with men. For patients receiving ICU care, fatal complications including AHF and mortality appeared to be independent of sex. Equitable access to COVID-19 ICU care is needed to minimize the unfavourable outcome of women presenting with COVID-19 related complications.
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- Comparison of reorganized versus unaltered cardiology departments during the COVID-19 era: a subanalysis of the COV-HF-SIRIO 6 study. [Journal Article]Cardiol J. 2023 Jan 18 [Online ahead of print]CJ
- CONCLUSIONS: In cardiology departments reorganized to provide care for COVID-19 patients vs. unaltered ones, observed: i) a greater reduction in hospital admissions in 2020 vs. 2019; ii) higher rates of patients brought by ambulance and lower rates of self-referrals; and iii) higher all-cause in-hospital mortality for AHF due to COVID-19 related deaths.
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- Efficacy and Safety of Shenfu Injection on Acute Heart Failure: A Systematic Review and Meta-Analysis. [Meta-Analysis]Phytomedicine. 2023 Feb; 110:154641.P
- CONCLUSIONS: Adjunctive use of SFI was safer to improve TCER and heart function of AHF, but the results should be interpreted with cautious for clinical practice until high quality-designed RCTs were require for further confirmation due to poor quality of part of the included studies.
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- Acute heart failure after non-cardiac surgery: incidence, phenotypes, determinants and outcomes. [Journal Article]Eur J Heart Fail. 2023 Jan 16 [Online ahead of print]EJ
- CONCLUSIONS: pAHF frequently developed following non-cardiac surgery, being de novo in half of cases, and associated with a very high mortality.
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- Incidence, Predictors, and Outcomes of Major Bleeding Among Patients Hospitalized With Acute Heart Failure. [Journal Article]Am J Cardiol. 2023 Jan 12; 191:59-65.AJ
- Acute heart failure (AHF) is a common etiology of hospitalization and is associated with morbidity, including bleeding. In this study, the authors sought to assess the incidence, types, and associates of major bleeding in patients hospitalized with AHF. The National Inpatient Sample from October 2015 to December 2018 was used to identify patients with AHF. The incidence of common bleeding etiolog…
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- Plasma GAS6 predicts mortality risk in acute heart failure patients: insights from the DRAGON-HF trial. [Journal Article]
- CONCLUSIONS: Elevated plasma GAS6 levels were associated with an increased risk of all-cause and cardiovascular death in patients with AHF. Trial registration NCT03727828 (DRAGON-HF trial) clinicaltrials.gov.
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- Recent developments on Junin virus, a causative agent for Argentine haemorrhagic fever. [Review]Rev Med Virol. 2023 Jan 12 [Online ahead of print]RM
- Junin virus consists of ribonucleic acid as the genome and is responsible for a rapidly changing tendency of the virus. The virus is accountable for ailments in the human body and causes Argentine Haemorrhagic Fever (AHF). The infection is may be transmitted through contact between an infected animal/host and a person, and later between person to person. Prevention of outbreaks of AHF in humans c…
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- Hypofractionation as a solution to radiotherapy access in latin america: expert perspective. [Review]
- CONCLUSIONS: Extending the adoption of HRT in LA can provide a path forward to increase access to radiotherapy and overcome the shortage of equipment. HRT has the potential to improve population health outcomes and patient centered care, while offering comparable local control, toxicity, palliation, and late effects for multiple indications, when compared to conventional RT. Concerted efforts from all involved stakeholders are needed to overcome the barriers in adopting this strategy in LA countries. The recommendations presented in this article can serve as a plan of action for HRT adoption in other countries in a similar situation.
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- Lung ultrasound in diagnosis of acute heart failure: A protocol for systematic review and meta-analysis. [Journal Article]
- CONCLUSIONS: This study conducted a systematic review of relevant studies, which aims to systematically evaluate the diagnostic value of lung ultrasound in AHF.
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- Relationship between Changes in Foot Arch and Sex Differences during the Menstrual Cycle. [Journal Article]
- This study investigated the relationship between changes in foot characteristics and sex differences during the menstrual cycle in healthy male and female university students. We examined 10 female subjects and 14 male subjects. The menstrual cycle was divided into the three phases: the early follicular phase, ovulatory phase, and luteal phase via basal body temperature, an ovulation kit, and sal…
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- Tricuspid Regurgitation in Acute Heart Failure: Predicting Outcome Using Novel Quantitative Echocardiography Techniques. [Journal Article]
- CONCLUSIONS: TR was not associated with outcome in AHF using guideline measures. A new assessment of "Disproportionate" TR carries a higher risk than proportionate TR but was not related to outcome based on multivariate analysis. Further research is needed to quantify TR more effectively to identify cut-offs for future guidelines and disproportionate TR may be an important part of Heart Failure 2.0.
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- Quantifying inflammation using interleukin-6 for improved phenotyping and risk stratification in acute heart failure. [Journal Article]Eur J Heart Fail. 2023 Jan 04 [Online ahead of print]EJ
- CONCLUSIONS: An unexpectedly high percentage of patients with AHF have subclinical systemic inflammation as quantified by interleukin-6, which seems to contribute to AHF phenotype and to the risk of death.
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- The Landscape of Vitiligo in Latin America: A Call to Action. [Review]J Dermatolog Treat. 2023 Jan 03 [Online ahead of print]JD
- Vitiligo is a chronic pigmentary condition and severely impacts patient quality of life (QoL). It is an underrecognized burden for patients, healthcare systems, and society in Latin America (LA). This paper examines the journey of a vitiligo patient in LA and assesses the disease landscape. Americas Health Foundation (AHF) assembled a panel of six Argentine, Brazilian, Colombian, and Mexican viti…
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- Trajectory of Decongestion and Mortality in Young Adults with Acute Heart Failure. [Review]Curr Probl Cardiol. 2022 Dec 30; 48(4):101579.CP
- Although the prevalence of HF in young adults (age <50 years) is increasing, there are limited data on the trajectory of decongestion and short-term outcomes in young adults with acute heart failure (AHF). We pooled patients from 3 randomized trials of AHF conducted within the Heart Failure Network (the Diuretic Optimization Strategies trial, the Renal Optimization Strategies Trial, and the Cardi…
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- Mammarenavirus Genetic Diversity and Its Biological Implications. [Review]Curr Top Microbiol Immunol. 2023; 439:265-303.CT
- Members of the family Arenaviridae are classified into four genera: Antennavirus, Hartmanivirus, Mammarenavirus, and Reptarenavirus. Reptarenaviruses and hartmaniviruses infect (captive) snakes and have been shown to cause boid inclusion body disease (BIBD). Antennaviruses have genomes consisting of 3, rather than 2, segments, and were discovered in actinopterygian fish by next-generation sequenc…
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- Cardiovascular and renal effects of SGLT2 inhibitor initiation in acute heart failure: a meta-analysis of randomized controlled trials. [Journal Article]
- CONCLUSIONS: SGLT2i addition to conventional diuretic therapy reduced all-cause death, readmissions for HF, and the composite of cardiovascular death or readmissions for HF. Moreover, SGLT2i was associated with a higher volume of diuresis with a lower dose of loop diuretics.
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- Effect of eplerenone on clinical stability of Japanese patients with acute heart failure. [Journal Article]Int J Cardiol. 2022 Dec 28 [Online ahead of print]IJ
- CONCLUSIONS: Eplerenone treatment improved the clinical stability particularly during short period following hospitalization for AHF, translated by lower diuretic doses, natriuretic peptide levels, indirect markers of filling pressure and venous congestion, and a smaller LV volume.
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- Trajectory of serum chloride levels during decongestive therapy in acute heart failure. [Journal Article]Int J Cardiol. 2022 Dec 28 [Online ahead of print]IJ
- CONCLUSIONS: Persistent hypochloremia was associated with worse clinical outcomes, while resolved hypochloremia and normochloremia showed a comparable prognosis. Changes in serum chloride levels can help identify patients with poor prognoses and can be used to determine subsequent treatment strategies.
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- External Validation of the Japanese Clinical Score for Mortality Prediction in Patients With Acute Heart Failure. [Journal Article]Circ J. 2022 Dec 28 [Online ahead of print]CJ
- CONCLUSIONS: The unique prediction score may be used in different geographic areas in Japan. The score may help doctors estimate the risk of AHF mortality, and provide information for decisions regarding heart failure treatment.
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