- Eliminating malaria, tuberculosis & HIV/AIDS in South-East Asia: Why cross-border is so critical. [Editorial]Indian J Med Res. 2022 Sep; 156(3):368-371.IJ
- Publisher Full Text (DOI)
- Impact of antibiotic treatment on the gut microbiome and its resistome in hematopoietic stem cell transplant recipients. [Journal Article]J Infect Dis. 2023 Feb 08 [Online ahead of print]JI
- Antibiotic resistant bacterial infections are increasingly an issue in allogenic hematopoietic stem cell transplant patients. How antibiotic treatment impacts antibiotic resistance in the human gut microbiome remains poorly understood in vivo. Here, a total of 577 fecal samples from 233 heavily antibiotic-treated transplant patients were examined using high-resolution prescription data and shotgu…
- Publisher Full Text (DOI)
- Clinical and Epidemiology Characteristics of COVID-19 Cases Detected During Mass Screening Campaign from July to October 2020 in Bujumbura, Burundi. [Journal Article]East Afr Health Res J. 2022; 6(2):127-133.EA
- CONCLUSIONS: This study revealed that a significant proportion (32.5%) of COVID-19 patients were silent carriers of the virus. Data highlighted that high proportion of cases were among the active age group and contacts with confirmed cases, and noted high proportion of asymptomatic cases at diagnosis. Measures including routine testing of asymptomatic contacts could contribute to tackling corona virus in Burundi.
- PMC Free PDF
- Disparity of HIV-1 Pretreatment Drug Resistance in Men Who Have Sex With Men and the Heterosexual Population in Guangxi, China. [Journal Article]Open Forum Infect Dis. 2023 Feb; 10(2):ofad016.OF
- CONCLUSIONS: The prevalence of PDR was different between MSM and HES, which may be associated with subtype. Thus, the monitoring of subtype and PDR should be strengthened.
- PMC Free PDF
- Cumulative Human Immunodeficiency Virus (HIV)-1 Viremia Is Associated With Increased Risk of Multimorbidity Among US Women With HIV, 1997-2019. [Journal Article]Open Forum Infect Dis. 2023 Feb; 10(2):ofac702.OF
- CONCLUSIONS: Among ART-treated WWH, greater cumulative viremia increased the risk of multimorbidity and of developing each NACM, and hence this may be a prognostically useful biomarker for NACM risk assessment in this population.
- PMC Free PDF
- Effect of a ward-based outreach team and adherence game on retention and viral load suppression. [Journal Article]South Afr J HIV Med. 2022; 23(1):1446.SA
- CONCLUSIONS: This study demonstrated that an adherence game intervention could help keep PLWH in care.
- PMC Free PDF
- HIV-Related Knowledge, Attitude, and Practices Research Among College Students - Six Chinese Cities, 2021. [Journal Article]China CDC Wkly. 2022 Nov 25; 4(47):1043-1050.CC
- The number of newly diagnosed human immunodeficiency virus (HIV) cases among Chinese youth 15-24 years of age shows an upward trend between 2010 and 2019.
- PMC Free PDF
- A Case of Pericardial Effusion and Human Immunodeficiency Virus in the Postmodern Era. [Case Reports]Cureus. 2023 Jan; 15(1):e33349.C
- Pericardial effusion is a relatively common cardiac pathology associated with various infectious and non-infectious etiologies. In developed countries, viral pericarditis and idiopathic reasons are the two most common causes of this condition. Mycobacterium tuberculosis is prevalent in developing countries and is the most common cause of pericardial effusion in these regions. Parasitic and bacter…
- PMC Free PDF
- Mechanical Assist Device-Assisted Percutaneous Coronary Intervention: The Use of Impella Versus Extracorporeal Membrane Oxygenation as an Emerging Frontier in Revascularization in Cardiogenic Shock. [Review]Cureus. 2023 Jan; 15(1):e33372.C
- The extracorporeal membrane oxygenation (ECMO) procedure aids in the provision of prolonged cardiopulmonary support, whereas the Impella device (Abiomed, Danvers, MA) is a ventricular assist device that maintains circulation by pumping blood into the aorta from the left ventricle. Blood is circulated in parallel with the heart by Impella. It draws blood straight into the aorta from the left ventr…
- PMC Free PDF
- Molecular basis of RNA recognition by TBP of HIV-1 from multiple molecular dynamics simulations and energy predictions. [Journal Article]J Comput Chem. 2023 Feb 07 [Online ahead of print]JC
- The frequent outbreaks of the AIDS (Acquired Immune Deficiency Syndrome) pandemic and the limited availability of anti-Human Immunodeficiency Virus (HIV) drugs highlight the urgent need to develop new antiviral drugs. A detailed understanding of the interactions between TAR-Binding Proteins (TBP) and RNA will facilitate the discovery of new anti-AIDS drugs. In order to characterize and explore th…
- Publisher Full Text (DOI)
- The effectiveness of pay-for-performance contracts with non-governmental organizations in Afghanistan - results of a controlled interrupted time series analysis. [Journal Article]BMC Health Serv Res. 2023 Feb 07; 23(1):122.BH
- CONCLUSIONS: P4P contracts with NGOs led to a substantial improvement in service delivery at lower cost despite a very difficult security situation. The promising results from this large-scale experience warrant more extensive application of P4P contracts in other fragile settings or wherever coverage remains low.
- Publisher Full Text (DOI)
- Factors that influence the satisfaction of people living with HIV with differentiated antiretroviral therapy delivery models in east Central Uganda: a cross-sectional study. [Journal Article]BMC Health Serv Res. 2023 Feb 08; 23(1):127.BH
- CONCLUSIONS: Results showed that 64.2% of patients were satisfied with DSDM services. HIV service delivery and treatment factors (DSDM type, time in DSDM, WHO stage, ART adherence), plus social factors (employment and marital status, transport costs, alcohol consumption), were associated with patient satisfaction. DSDM implementers should tailor services to address these factors to improve patient satisfaction.
- Publisher Full Text (DOI)
- Potential role of doravirine for the treatment of HIV-1-infected persons with transmitted drug resistance. [Journal Article]AIDS Res Ther. 2023 Feb 07; 20(1):8.AR
- CONCLUSIONS: First-line therapy containing doravirine plus two NRTIs is expected to be effective in treating most persons with TDR as more than 80% of TDR sequences had a single NNRTI DRM and as more than 90% with a single DRM were expected to be susceptible to doravirine. However, caution is required for the use of doravirine in persons with more than one NNRTI DRM even if none of the DRMs are canonical doravirine-resistance mutations.
- Publisher Full Text (DOI)
- Assessment of an instrument scale measuring the knowledge of antiretroviral therapy among people living with HIV. [Journal Article]BMC Public Health. 2023 Feb 07; 23(1):278.BP
- CONCLUSIONS: The psychometric assessment indicated that this ART knowledge scale had accepted internal consistency and discriminant construct validity. It can be used to assess the knowledge of antiretroviral therapy for PLHs.
- Publisher Full Text (DOI)
- Student nurses' perceptions and experiences in caring for people living with HIV/AIDS: a qualitative study. [Journal Article]BMC Med Educ. 2023 Feb 07; 23(1):99.BM
- CONCLUSIONS: Findings shed light on the development and changes in student nurses' perspectives on PLWHAs throughout their clinical experiences. Student nurses' perceptions and attitudes toward PLWHAs progressed through three distinct stages, and positive changes were observed after care-giving. Participants' perceptions and practical experiences with patients with AIDS enable patients to receive fair and high-quality care and provide valuable insights for nursing educators better prepare HIV nurses.
- Publisher Full Text (DOI)
- New designs for HIV-1 integrase inhibitors: a patent review (2018-present). [Journal Article]Expert Opin Ther Pat. 2023 Feb 07 [Online ahead of print]EO
- Combination antiretroviral therapy (cART) has dramatically reduced morbidity and mortality of HIV-1-infected patients. Integrase strand transfer inhibitors (INSTIs) play an important role as a key drug in cART. The second-generation INSTIs are very potent, but due to the emergence of highly resistant viruses and the demand for more conveniently usable drugs, the development of "third-generation" …
- Publisher Full Text (DOI)
- Epidemiological and genomic analysis of dengue cases in Guangzhou, China, from 2010 to 2019. [Journal Article]Sci Rep. 2023 Feb 07; 13(1):2161.SR
- With a long epidemic history and a large number of dengue cases, Guangzhou is a key city for controlling dengue in China. The demographic information regarding dengue cases, and the genomic characteristics of the envelope gene of dengue viruses, as well as the associations between these factors were investigated from 2010 to 2019, to improve the understanding of the epidemiology of dengue in Guan…
- Publisher Full Text (DOI)
- Impact of COVID-19 Pandemic on HIV Testing Uptake Among Key Populations Enrolled in Targeted Intervention Program in Maharashtra, India. [Journal Article]AIDS Behav. 2023 Feb 07 [Online ahead of print]AB
- The COVID-19 pandemic posed unprecedented challenges to HIV services globally. We evaluated the impact of the COVID-19 pandemic on the uptake of HIV testing in the Targeted Intervention (TI) program in Maharashtra-a high HIV burden state in India. Annual HIV testing was sustained during the pandemic year (2020-2021), at levels similar to the pre-pandemic year (2019-2020), among Female Sex Workers…
- Publisher Full Text (DOI)
- Monkeypox-induced proctitis: a case report of an emerging complication. [Journal Article]Infection. 2023 Feb 07 [Online ahead of print]I
- CONCLUSIONS: As more cases of monkeypox-associated proctitis emerge, clinicians should keep this disease in their differential due to the growing atypical presentations that have diverged from previous patterns to avoid the risk of misdiagnosing another sexually transmitted infection. Additionally, appropriate medical management is still not definitive and requires further development of evidence-based protocols to treat such patients.
- Publisher Full Text (DOI)
- Epidemiology of herpes simplex virus type 1 and genital herpes in Australia and New Zealand: Systematic review, meta-analyses, and meta-regressions. [Review]Epidemiol Infect. 2023 Feb 08 [Online ahead of print]EI
- Publisher Full Text (DOI)
- Structures of LRP2 reveal a molecular machine for endocytosis. [Journal Article]Cell. 2023 Jan 28 [Online ahead of print]Cell
- The low-density lipoprotein (LDL) receptor-related protein 2 (LRP2 or megalin) is representative of the phylogenetically conserved subfamily of giant LDL receptor-related proteins, which function in endocytosis and are implicated in diseases of the kidney and brain. Here, we report high-resolution cryoelectron microscopy structures of LRP2 isolated from mouse kidney, at extracellular and endosoma…
- Publisher Full Text (DOI)
- Binaural Hearing Using the ADHEAR Bone Conduction System in the Monaurally Occluded Ear. [Journal Article]Audiol Neurootol. 2023 Feb 07 [Online ahead of print]AN
- CONCLUSIONS: Application of a bone conduction hearing aid in unilateral pseudo-conductive hearing loss strengthens speech recognition of noise by improving the summation effect and impeding the shadow effect of the head; however, there appears to be no improvement in speech perception in noise due to spatial release from masking.
- Publisher Full Text (DOI)
- Promoting conspiracy theory: From AIDS to COVID-19. [Review]Glob Public Health. 2023 Jan; 18(1):2172199.GP
- Conspiracy theories (evidence-free, improbable narratives about powerful agents conspiring to harm people) circulated widely during the acquired immune deficiency syndrome (AIDS) and COVID-19 epidemics. They travelled over time and space, adapted to local conditions and anxieties, and were promoted for commercial and political purposes. Russian conspiracy theories claiming the viruses were United…
- Publisher Full Text (DOI)
- Screening and diagnostic testing protocols for HIV and Syphilis infections in health care setting in Qatar: Evaluation and recommendations. [Journal Article]PLoS One. 2023; 18(2):e0278079.Plos
- CONCLUSIONS: Despite the high rate of false positivity using ARCHITECT® HIV Ag/Ab Combo and RPR screening assays, both assays have proven to be highly effective as screening testing methods.
- Publisher Full Text (DOI)
- Faster progression to multiple sclerosis disability is linked to neuronal pathways associated with neurodegeneration: An ethnicity study. [Journal Article]PLoS One. 2023; 18(2):e0280515.Plos
- Although the causes of multiple sclerosis are largely unknown, genetic and environmental components play an important role. Geographic distribution, varying with latitude, reflects both genetic and environmental influences. We conducted a retrospective exploratory observational study to characterize the disability progression of 2396 Jewish patients with relapsing-remitting multiple sclerosis, fo…
- Publisher Full Text (DOI)
- Late gene expression-deficient cytomegalovirus vectors elicit conventional T cells that do not protect against SIV. [Journal Article]JCI Insight. 2023 Feb 07 [Online ahead of print]JI
- Rhesus cytomegalovirus (RhCMV)-based vaccine vectors induce immune responses that protect ~60% of rhesus macaques (RMs) from SIVmac239 challenge. This efficacy depends on induction of effector memory (EM)-biased CD8+ T cells recognizing SIV peptides presented by major histocompatibility complex (MHC)-E instead of MHC-Ia. The phenotype, durability, and efficacy of RhCMV/SIV-elicited cellular immun…
- Publisher Full Text (DOI)
- Predictors of death among TB/HIV co-infected patients on tuberculosis treatment in Sichuan, China: A retrospective cohort study. [Journal Article]Medicine (Baltimore). 2023 Feb 03; 102(5):e32811.M
- Mycobacterium tuberculosis is the most common opportunistic infection among patients with human immunodeficiency virus (HIV) infection, and it is also the leading cause of death, causing approximately one-third of acquired immune deficiency syndrome deaths worldwide. China is on the World Health Organization's global list of 30 high-tuberculosis (TB) burden countries. The objective of this study …
- Publisher Full Text (DOI)
- [Influence of hearing aid on speech recognition ability, psychology and cognitive function of presbycusis]. [Journal Article]Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2023 Feb 07; 58(2):160-165.ZE
- Publisher Full Text (DOI)
- Preclinical evaluation of a COVID-19 vaccine candidate based on a recombinant RBD fusion heterodimer of SARS-CoV-2. [Journal Article]iScience. 2023 Feb 02 [Online ahead of print]I
- Current COVID-19 vaccines have been associated with a decline in infection rates, prevention of severe disease and a decrease in mortality rates. However, SARS-CoV-2 variants are continuously evolving, and development of new accessible COVID-19 vaccines is essential to mitigate the pandemic. Here, we present data on preclinical studies in mice of a receptor-binding domain (RBD)-based recombinant …
- PMC Free PDF
- Ndel1 modulates dynein activation in two distinct ways. [Preprint]bioRxiv. 2023 Jan 25B
- Dynein is the primary minus-end-directed microtubule motor [1]. To achieve activation, dynein binds to the dynactin complex and an adaptor to form the "activated dynein complex" [2, 3]. The protein Lis1 aids activation by binding to dynein and promoting its association with dynactin and adaptor [4, 5]. Ndel1 and its orthologue Nde1 are dynein and Lis1 binding proteins that help control where dyne…
- PMC Free PDF