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299,721 results
  • A Case of Pericardial Effusion and Human Immunodeficiency Virus in the Postmodern Era. [Case Reports]
    Cureus. 2023 Jan; 15(1):e33349.Silverio Lopez R, Agrawal P
  • Pericardial effusion is a relatively common cardiac pathology associated with various infectious and non-infectious etiologies. In developed countries, viral pericarditis and idiopathic reasons are the two most common causes of this condition. Mycobacterium tuberculosis is prevalent in developing countries and is the most common cause of pericardial effusion in these regions. Parasitic and bacter…
  • Potential role of doravirine for the treatment of HIV-1-infected persons with transmitted drug resistance. [Journal Article]
    AIDS Res Ther. 2023 Feb 07; 20(1):8.Rhee SY, Schapiro JM, … Shafer RW
  • CONCLUSIONS: First-line therapy containing doravirine plus two NRTIs is expected to be effective in treating most persons with TDR as more than 80% of TDR sequences had a single NNRTI DRM and as more than 90% with a single DRM were expected to be susceptible to doravirine. However, caution is required for the use of doravirine in persons with more than one NNRTI DRM even if none of the DRMs are canonical doravirine-resistance mutations.
  • Student nurses' perceptions and experiences in caring for people living with HIV/AIDS: a qualitative study. [Journal Article]
    BMC Med Educ. 2023 Feb 07; 23(1):99.Shi C, Cleofas JV
  • CONCLUSIONS: Findings shed light on the development and changes in student nurses' perspectives on PLWHAs throughout their clinical experiences. Student nurses' perceptions and attitudes toward PLWHAs progressed through three distinct stages, and positive changes were observed after care-giving. Participants' perceptions and practical experiences with patients with AIDS enable patients to receive fair and high-quality care and provide valuable insights for nursing educators better prepare HIV nurses.
  • New designs for HIV-1 integrase inhibitors: a patent review (2018-present). [Journal Article]
    Expert Opin Ther Pat. 2023 Feb 07 [Online ahead of print]Taoda Y, Sugiyama S, Seki T
  • Combination antiretroviral therapy (cART) has dramatically reduced morbidity and mortality of HIV-1-infected patients. Integrase strand transfer inhibitors (INSTIs) play an important role as a key drug in cART. The second-generation INSTIs are very potent, but due to the emergence of highly resistant viruses and the demand for more conveniently usable drugs, the development of "third-generation" …
  • Epidemiological and genomic analysis of dengue cases in Guangzhou, China, from 2010 to 2019. [Journal Article]
    Sci Rep. 2023 Feb 07; 13(1):2161.Jiang L, Liu Y, … Di B
  • With a long epidemic history and a large number of dengue cases, Guangzhou is a key city for controlling dengue in China. The demographic information regarding dengue cases, and the genomic characteristics of the envelope gene of dengue viruses, as well as the associations between these factors were investigated from 2010 to 2019, to improve the understanding of the epidemiology of dengue in Guan…
  • Monkeypox-induced proctitis: a case report of an emerging complication. [Journal Article]
    Infection. 2023 Feb 07 [Online ahead of print]Rathore A, Kahn C, … House JG
  • CONCLUSIONS: As more cases of monkeypox-associated proctitis emerge, clinicians should keep this disease in their differential due to the growing atypical presentations that have diverged from previous patterns to avoid the risk of misdiagnosing another sexually transmitted infection. Additionally, appropriate medical management is still not definitive and requires further development of evidence-based protocols to treat such patients.
  • Structures of LRP2 reveal a molecular machine for endocytosis. [Journal Article]
    Cell. 2023 Jan 28 [Online ahead of print]Beenken A, Cerutti G, … Shapiro L
  • The low-density lipoprotein (LDL) receptor-related protein 2 (LRP2 or megalin) is representative of the phylogenetically conserved subfamily of giant LDL receptor-related proteins, which function in endocytosis and are implicated in diseases of the kidney and brain. Here, we report high-resolution cryoelectron microscopy structures of LRP2 isolated from mouse kidney, at extracellular and endosoma…
  • Binaural Hearing Using the ADHEAR Bone Conduction System in the Monaurally Occluded Ear. [Journal Article]
    Audiol Neurootol. 2023 Feb 07 [Online ahead of print]Canale A, Ndrev D, … Albera A
  • CONCLUSIONS: Application of a bone conduction hearing aid in unilateral pseudo-conductive hearing loss strengthens speech recognition of noise by improving the summation effect and impeding the shadow effect of the head; however, there appears to be no improvement in speech perception in noise due to spatial release from masking.
  • Promoting conspiracy theory: From AIDS to COVID-19. [Review]
    Glob Public Health. 2023 Jan; 18(1):2172199.Nattrass N
  • Conspiracy theories (evidence-free, improbable narratives about powerful agents conspiring to harm people) circulated widely during the acquired immune deficiency syndrome (AIDS) and COVID-19 epidemics. They travelled over time and space, adapted to local conditions and anxieties, and were promoted for commercial and political purposes. Russian conspiracy theories claiming the viruses were United…
  • Ndel1 modulates dynein activation in two distinct ways. [Preprint]
    bioRxiv. 2023 Jan 25Garrott SR, Gillies JP, … DeSantis ME
  • Dynein is the primary minus-end-directed microtubule motor [1]. To achieve activation, dynein binds to the dynactin complex and an adaptor to form the "activated dynein complex" [2, 3]. The protein Lis1 aids activation by binding to dynein and promoting its association with dynactin and adaptor [4, 5]. Ndel1 and its orthologue Nde1 are dynein and Lis1 binding proteins that help control where dyne…
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