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46,008 results
  • Developing a new biologic toxin binder for reducing AFB1 toxicity in laying hens. [Journal Article]
    Lett Appl Microbiol. 2023 Feb 06 [Online ahead of print]Poroj SN, Fazeli MR, … Shariatmadari F
  • Aflatoxin (AFs)-contaminated diet in feeding domestic animals is one of the biggest health concerns for humans. Therefore, various methods have been developed to detoxify AFs. In the present study, adding Saccharomyces cerevisiae probiotic yeast and titanium dioxide nanoparticles (TiO2-NPs) reduces the toxicity of Aflatoxin B1 (AFB1) in laying hens was studied. After preparing laying hens, they w…
  • Quince extract resists atherosclerosis in rats by down-regulating the EGFR/PI3K/Akt/GSK-3β pathway. [Journal Article]
    Biomed Pharmacother. 2023 Feb 04; 160:114330.Abulizi A, Simayi J, … Zhou W
  • We identified the effective components and the underlying mechanisms of Quince (Cydonia oblonga Mill, COM) extract against atherosclerosis. The effective components of COM extract were identified with UHPLC-Q-TOF-MS/MS. Network pharmacology was performed. A rat model of atherosclerosis induced by high-fat emulsion combined with vitamin D3 was established. The anti-atherosclerosis effect of COM ex…
  • Red-fleshed apple flavonoid extract alleviates CCl4-induced liver injury in mice. [Journal Article]
    Front Nutr. 2022; 9:1098954.Chen Y, Wang Y, … Zhang Y
  • In recent years, the global incidence of liver damage has increased. Despite the many known health benefits of red-fleshed apple flavonoids, their potential liver-protective effects have not yet been investigated. In this study, we analyzed the composition of red-fleshed apple flavonoid extract (RAFE) by high-performance liquid chromatography (HPLC). We then induced liver damage in mice with carb…
  • [Effects of interleukin-4-modified gold nanozymes on the full-thickness skin defects in diabetic mice]. [Journal Article]
    Zhonghua Shao Shang Za Zhi. 2023 Jan 20; 39(1):15-24.Yao MY, Zhang N, … Luo GX
  • Objective: To investigate the effects and mechanism of interleukin-4-modified gold nanoparticle (IL-4-AuNP) on the wound healing of full-thickness skin defects in diabetic mice. Methods: Experimental research methods were adopted. Gold nanoparticle (AuNP) and IL-4-AuNP were synthesized by improving the methods described in published literature. The morphology of those two particles were photograp…
  • A novel type lavandulyl flavonoid from Sophora flavescens as potential anti-hepatic injury agent that inhibit TLR2/NF-κB signaling pathway. [Journal Article]
    J Ethnopharmacol. 2023 Feb 02 [Online ahead of print]Lin Y, Chen XJ, … Zeng Z
  • CONCLUSIONS: These findings demonstrated that the novel compound (kurarinol A, 1) possessed notable hepatoprotective activity against CCl4. It was confirmed that kurarinol A had a certain effect on mice with liver damage induced by CCl4, and its mechanism could be include inhibiting inflammation and reducing of oxidative stress reaction by regulating expression of related genes and proteins. Thus, kurarinol A could as a novel active agent that contributes to the hepatoprotective activity of S. flavescens for the treatment of live injury.
  • A Human Liver Organoid Screening Platform for DILI Risk Prediction. [Journal Article]
    J Hepatol. 2023 Feb 02 [Online ahead of print]Zhang CJ, Meyer SR, … Sexton JZ
  • CONCLUSIONS: The high throughput and liver-on-chip system exhibit enhanced in vivo-like function and demonstrate the potential utility of these platforms for hepatotoxicity risk assessment. Tenofovir-inarigivr associated hepatotoxicity was observed and correlates with the clinical manifestation of DILI observed in patients.
  • Optical characterisation of two novel myopia control spectacle lenses. [Journal Article]
    Ophthalmic Physiol Opt. 2023 Feb 04 [Online ahead of print]Gantes-Nuñez J, Jaskulski M, … Kollbaum PS
  • CONCLUSIONS: Varying sagittal power and consistent curvature power across the lenslets is an identifying signature of the novel non-coaxial lens design included in both spectacle lenses. Lenslet array structure itself plays a significant role in determining image characteristics. For both lenses, the blur created by the fragmented base optic contributes to the image quality. The reduced MTFs over a wide range of spatial frequencies result in lowered image contrast.
  • Age-specific risk factors for the prediction of obesity using a machine learning approach. [Journal Article]
    Front Public Health. 2022; 10:998782.Jeon J, Lee S, Oh C
  • Machine Learning is a powerful tool to discover hidden information and relationships in various data-driven research fields. Obesity is an extremely complex topic, involving biological, physiological, psychological, and environmental factors. One successful approach to the topic is machine learning frameworks, which can reveal complex and essential risk factors of obesity. Over the last two decad…
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