- Crocin treatment exerts anti-inflammatory and anti-oxidative effects in liver tissue damage of pinealectomized diabetic rats. [Journal Article]Environ Sci Pollut Res Int. 2023 Feb 06 [Online ahead of print]ES
- Diabetes mellitus (DM) is a chronic metabolic disorder with an increasing global prevalence that leads to significant morbidity and mortality. The liver plays a vital role in glycemic regulation in physiological and pathological conditions such as DM. Free radical formation and inhibition of antioxidant defense systems play a role in the liver damage pathogenesis in diabetic patients The antioxid…
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- Developing a new biologic toxin binder for reducing AFB1 toxicity in laying hens. [Journal Article]Lett Appl Microbiol. 2023 Feb 06 [Online ahead of print]LA
- Aflatoxin (AFs)-contaminated diet in feeding domestic animals is one of the biggest health concerns for humans. Therefore, various methods have been developed to detoxify AFs. In the present study, adding Saccharomyces cerevisiae probiotic yeast and titanium dioxide nanoparticles (TiO2-NPs) reduces the toxicity of Aflatoxin B1 (AFB1) in laying hens was studied. After preparing laying hens, they w…
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- Quince extract resists atherosclerosis in rats by down-regulating the EGFR/PI3K/Akt/GSK-3β pathway. [Journal Article]Biomed Pharmacother. 2023 Feb 04; 160:114330.BP
- We identified the effective components and the underlying mechanisms of Quince (Cydonia oblonga Mill, COM) extract against atherosclerosis. The effective components of COM extract were identified with UHPLC-Q-TOF-MS/MS. Network pharmacology was performed. A rat model of atherosclerosis induced by high-fat emulsion combined with vitamin D3 was established. The anti-atherosclerosis effect of COM ex…
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- Comparing Effectiveness and Safety of SGLT2 Inhibitors vs DPP-4 Inhibitors in Patients With Type 2 Diabetes and Varying Baseline HbA1c Levels. [Journal Article]JAMA Intern Med. 2023 Feb 06 [Online ahead of print]JIM
- CONCLUSIONS: In this comparative effectiveness and safety research study among adults with T2D, SGLT2i vs DPP-4i treatment initiators had a reduced risk of modified MACE and HHF, an increased risk of genital infections and DKA, and a lower risk of AKI, regardless of baseline HbA1c.
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- MDM4 amplification in atypical lipomatous tumors/ well-differentiated liposarcoma: private event or alternative oncogenic mechanism? [Journal Article]Genes Chromosomes Cancer. 2023 Feb 06 [Online ahead of print]GC
- Adipocytic tumors are the most common mesenchymal tumors in soft tissues. Among them, a diagnostic challenge relies in the distinction between lipoma and Atypical Lipomatous Tumor (ALT)/Well Differentiated Liposarcoma (WDLPS), as both entities are often undistinguishable not only from a radiological point of view, but also at the microscopic level and particularly when dealing with small tumor sp…
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- Assessment of serum glutamate dehydrogenase activity and comparison to serum alanine aminotransferase activity in cats with increased blood total T4 concentration. [Journal Article]J Vet Diagn Invest. 2023 Feb 06 [Online ahead of print]JV
- Glutamate dehydrogenase (GLDH), a key enzyme in amino acid oxidation and urea production, is mainly derived from the liver and its activity may increase with hepatocellular necrosis. Feline hyperthyroidism is associated with elevated serum activities of various enzymes, but the pattern of serum GLDH activity has not been reported, to our knowledge. Feline clinical biochemistry results from 2 comm…
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- Association between different patterns of shift work and liver function tests: A cross-sectional analysis of Shahedieh PERSIAN cohort data, Iran, 2020. [Journal Article]Work. 2023 Feb 03 [Online ahead of print]WORK
- CONCLUSIONS: There was only a significant association between shift work and elevated AST, and no relationship was found with ALT, ALP, GGT, and ALT/AST ratio.
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- Mechanism of crocin I on ANIT-induced intrahepatic cholestasis by combined metabolomics and transcriptomics. [Journal Article]Front Pharmacol. 2022; 13:1088750.FP
- Background: Intrahepatic cholestasis (IC) is a disorder of bile production, secretion, and excretion with various causes. Crocin I (CR) is effective in the treatment of IC, but its underlying mechanisms need to be further explored. We aimed to reveal the therapeutic mechanism of crocin I for IC by combining an integrated strategy of metabolomics and transcriptomics. Methods: The hepatoprotective …
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- Genetic variants of IFIH1 and DHX58 affect the chronicity of hepatitis C in the Chinese Han population. [Journal Article]PeerJ. 2023; 11:e14740.P
- Hepatitis C remains a major public health problem in the world. The host immune system plays a key role in viral clearance. This study aimed to investigate the connection between retinoic acid-inducible gene I-like (RIG-I-like) receptor gene polymorphism and hepatitis C chronicity in the Chinese Han population. The current study genotyped three SNPs (IFIH1 rs10930046 and DHX58 rs2074158, rs207416…
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- The spleen-strengthening and liver-draining herbal formula treatment of non-alcoholic fatty liver disease by regulation of intestinal flora in clinical trial. [Journal Article]Front Endocrinol (Lausanne). 2022; 13:1107071.FE
- CONCLUSIONS: SLF can improve liver function and glucolipid metabolism in patients with NAFLD and lower down liver fat content to some extent. SLF could be carried out by regulating the disturbance of intestinal flora, especially Coprococcus, Lachnospiraceae_NK4A136 group, and Ruminococcus genus.
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- The association of alanine aminotransferase and diabetic microvascular complications: A Mendelian randomization study. [Journal Article]Front Endocrinol (Lausanne). 2023; 14:1104963.FE
- CONCLUSIONS: With caution, we concluded that ALT plays no linear causal role in developing both diabetic nephropathy and diabetic retinopathy. Further investigations are required to test the hypothesis of a non-linear causal association.
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- p-Coumaric acid has pure anti-inflammatory characteristics against hepatopathy caused by ischemia-reperfusion in the liver and dust exposure. [Journal Article]Iran J Basic Med Sci. 2023 Feb; 26(2):164-175.IJ
- CONCLUSIONS: p-CA alleviated pathological changes caused by dust exposure and IR injury. p-CA protected hepatic injury induced by dust and IR by inhibition of oxidative injury, inflammation, and autophagy.
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- Red-fleshed apple flavonoid extract alleviates CCl4-induced liver injury in mice. [Journal Article]Front Nutr. 2022; 9:1098954.FN
- In recent years, the global incidence of liver damage has increased. Despite the many known health benefits of red-fleshed apple flavonoids, their potential liver-protective effects have not yet been investigated. In this study, we analyzed the composition of red-fleshed apple flavonoid extract (RAFE) by high-performance liquid chromatography (HPLC). We then induced liver damage in mice with carb…
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- The association of the paraoxonase 1 Q192R polymorphism with coronary artery disease (CAD) and cardiometabolic risk factors in Iranian patients suspected of CAD. [Journal Article]Front Cardiovasc Med. 2022; 9:1037940.FC
- The present study aimed to investigate the association of the paraoxonase 1 (PON1) Q192R polymorphism with coronary artery disease (CAD) and cardiometabolic risk factors in Iranian patients suspected of CAD.
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- A nomogram based on HBeAg, AST, and age to predict non-minimal liver inflammation in CHB patients with ALT <80 U/L. [Journal Article]Front Immunol. 2022; 13:1119124.FI
- CONCLUSIONS: The nomogram based on HBeAg, AST, and age might help predict non-minimal liver inflammation in HBeAg-positive CHB patients with ALT < 80 U/L, which is practical and easy to use for clinicians.
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- Serum metabolomics strategy for investigating the hepatotoxicity induced by different exposure times and doses of Gynura segetum (Lour.) Merr. in rats based on GC-MS. [Journal Article]RSC Adv. 2023 Jan 11; 13(4):2635-2648.RA
- Gynura segetum (Lour.) Merr. (GS), has been widely used in Chinese folk medicine and can promote circulation, relieve pain and remove stasis. In recent years, the hepatotoxicity caused by GS has been reported, however its mechanism is not fully elucidated. Metabolomic techniques are powerful means to explore the toxicological mechanism and therapeutic effects of traditional Chinese medicine. The …
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- [Effects of interleukin-4-modified gold nanozymes on the full-thickness skin defects in diabetic mice]. [Journal Article]Zhonghua Shao Shang Za Zhi. 2023 Jan 20; 39(1):15-24.ZS
- Objective: To investigate the effects and mechanism of interleukin-4-modified gold nanoparticle (IL-4-AuNP) on the wound healing of full-thickness skin defects in diabetic mice. Methods: Experimental research methods were adopted. Gold nanoparticle (AuNP) and IL-4-AuNP were synthesized by improving the methods described in published literature. The morphology of those two particles were photograp…
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- The influence of sex and age on bone turnover markers in the adult to geriatric Kangal shepherd dogs. [Journal Article]Vet Clin Pathol. 2023 Feb 05 [Online ahead of print]VC
- CONCLUSIONS: These results show the effect of age and sex on bone turnover in Kangal shepherd dogs and provide information about bone biomarkers.
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- In ovo protective effects of chicoric and rosmarinic acids against Thiacloprid-induced cytotoxicity, oxidative stress, and growth retardation on newly hatched chicks. [Journal Article]Poult Sci. 2023 Jan 09; 102(4):102487.PS
- Thiacloprid (TH) is a neonicotinoid insecticide employed in agriculture to protect fruits and vegetables against different insects. It showed different deleterious effects on the general health of non-target organisms including birds and animals, however, its developmental toxicity has yet to be fully elucidated. Chicoric (CA) and rosmarinic (RA) acids are polyphenolic compounds with a wide range…
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- Recurrent meningitis caused by Salmonella enterica Paratyphi B var. Java in a 3-month-old infant complicated by dilation of subarachnoid spaces, subdural effusion and right-sided hemiparesis. [Journal Article]Paediatr Int Child Health. 2023 Feb 05 [Online ahead of print]PI
- A 3-month-old female infant with meningo-encephalitis caused by Salmonella enterica Paratyphi B var. Java is described. The aetiological agent was confirmed in six CSF samples; however, none of the blood or faecal samples was positive for the same pathogen. The presence of the bacteria was confirmed in the CSF by culture, serology and Multiplex PCR assay. The infant developed dilated subarachnoid…
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- A novel type lavandulyl flavonoid from Sophora flavescens as potential anti-hepatic injury agent that inhibit TLR2/NF-κB signaling pathway. [Journal Article]J Ethnopharmacol. 2023 Feb 02 [Online ahead of print]JE
- CONCLUSIONS: These findings demonstrated that the novel compound (kurarinol A, 1) possessed notable hepatoprotective activity against CCl4. It was confirmed that kurarinol A had a certain effect on mice with liver damage induced by CCl4, and its mechanism could be include inhibiting inflammation and reducing of oxidative stress reaction by regulating expression of related genes and proteins. Thus, kurarinol A could as a novel active agent that contributes to the hepatoprotective activity of S. flavescens for the treatment of live injury.
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- A Human Liver Organoid Screening Platform for DILI Risk Prediction. [Journal Article]J Hepatol. 2023 Feb 02 [Online ahead of print]JH
- CONCLUSIONS: The high throughput and liver-on-chip system exhibit enhanced in vivo-like function and demonstrate the potential utility of these platforms for hepatotoxicity risk assessment. Tenofovir-inarigivr associated hepatotoxicity was observed and correlates with the clinical manifestation of DILI observed in patients.
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- Elevated alanine transaminase is nonlinearly associated with in-hospital death in ICU-admitted diabetic ketoacidosis patients. [Journal Article]Diabetes Res Clin Pract. 2023 Feb 02 [Online ahead of print]DR
- CONCLUSIONS: Elevated ALT is robustly associated with in-hospital death in ICU-admitted DKA patients across several subgroups. Close monitoring of ALT in these patients is recommended.
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- A dry chemistry-based electrochemiluminescence device for point-of-care testing of alanine transaminase. [Journal Article]Talanta. 2023 Jan 20; 256:124287.T
- Liver disease causes serious public health problems because of its high prevalence, particularly affecting low- and middle-income countries. Alanine transaminase (ALT) is considered to be one of the most sensitive indicators for diagnosing liver disease. Although many strategies have been reported for ALT detection, few of them have solved the problem of automatic detection. In this work, for the…
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- Acetaminophen-induced hepatotoxicity predominantly via inhibiting Nrf2 antioxidative pathway and activating TLR4-NF-κB-MAPK inflammatory response in mice. [Journal Article]Ecotoxicol Environ Saf. 2023 Feb 02; 252:114590.EE
- To explore the action time and molecular mechanism underlying the effect of acetaminophen (APAP) on liver injury. APAP was used to establish drug-induced liver injury (DILI) model in mice. Mice in the model group were intraperitoneally injected 300 mg/kg APAP for 6, 12, and 24 h respectively, and control group mice were given the same volume of normal saline. The mice were anesthetized through in…
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- A new glutamine synthetase index to evaluate hepatic lobular restoration in advanced fibrosis during anti-HBV therapy. [Journal Article]J Med Virol. 2023 Feb 04 [Online ahead of print]JM
- Hepatic lobular architecture distortion is a deleterious turning point and a crucial histological feature of advanced liver fibrosis in chronic liver diseases. Regression of fibrosis has been documented in chronic hepatitis B (CHB) patients. However, whether lobular architecture could be restored following fibrosis regression after antiviral therapy is still unclear. Glutamine synthetase (GS) is …
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- Optical characterisation of two novel myopia control spectacle lenses. [Journal Article]Ophthalmic Physiol Opt. 2023 Feb 04 [Online ahead of print]OP
- CONCLUSIONS: Varying sagittal power and consistent curvature power across the lenslets is an identifying signature of the novel non-coaxial lens design included in both spectacle lenses. Lenslet array structure itself plays a significant role in determining image characteristics. For both lenses, the blur created by the fragmented base optic contributes to the image quality. The reduced MTFs over a wide range of spatial frequencies result in lowered image contrast.
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- M1 macrophages may be effective adjuvants for promoting Th‑17 differentiation in HBeAg positive hepatitis patients with ALT ≤2ULN. [Journal Article]Mol Med Rep. 2023 Mar; 27(3)MM
- Hepatitis B virus (HBV) infection can activate macrophages to accelerate liver disease progression, including inflammation and fibrosis. However, the exact mechanism remains undetermined. The present study assessed the effects of macrophage polarization and the related cytokines on Th‑17 differentiation in HBeAg positive individuals with a HBV infection, and also evaluated the potential associati…
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- Age-specific risk factors for the prediction of obesity using a machine learning approach. [Journal Article]
- Machine Learning is a powerful tool to discover hidden information and relationships in various data-driven research fields. Obesity is an extremely complex topic, involving biological, physiological, psychological, and environmental factors. One successful approach to the topic is machine learning frameworks, which can reveal complex and essential risk factors of obesity. Over the last two decad…
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- Swimming exercise reduces oxidative stress and liver damage indices of male rats exposed to electromagnetic radiation. [Journal Article]Life Sci. 2023 Jan 30; 317:121461.LS
- CONCLUSIONS: The study findings showed that the SE is beneficial in attenuating the harmful effects of RF-EMR emitted from the Wi-Fi on the liver.
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