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1,394 results
  • A novel lidocaine hydrochloride mucoadhesive films for periodontal diseases. [Journal Article]
    J Mater Sci Mater Med 2019; 30(1):14Pleguezuelos-Villa M, Nácher A, … Díez-Sales O
  • Periodontal diseases are inflammatory disorders caused primarily by dental plaque microorganisms that even may need surgery to remove damaged tissue. Adhesive biocompatible films may be an adequate form in order to improve drug retention or prevent microbial infections by covering the surgical site. In recent years, much attention has been focused on biocompatible inexpensive polymers, for biomed…
  • Full-Thickness Intraoral Mucosa Barrier Models for In Vitro Drug-Permeation Studies Using Microneedles. [Journal Article]
    J Pharm Sci 2019; 108(5):1756-1764Serpe L, Muniz BV, … Franz-Montan M
  • The use of permeation enhancers such as microneedles (MNs) to increase drug penetration across intraoral mucosa has increased in recent years. Permeation studies, commonly performed using vertical diffusion cells, are a well-established way to preview formulations and enhance their performance during the development stage. However, to our knowledge, the existing intraoral mucosa barrier models do…
  • The Effect of Dexmedetomidine on Oral Mucosal Blood Flow and the Absorption of Lidocaine. [Journal Article]
    Anesth Prog 2018; 65(3):168-176Tomita S, Yamazaki S, … Kawaai H
  • Dexmedetomidine (DEX) is a sedative and analgesic agent that acts via the alpha-2 adrenoreceptor and is associated with reduced anesthetic requirements, as well as attenuated blood pressure and heart rate in response to stressful events. A previous study reported that cat gingival blood flow was controlled via sympathetic alpha-adrenergic fibers involved in vasoconstriction. In the present study,…
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