- Notoginsenoside Fc ameliorates renal tubular injury and mitochondrial damage in acetaminophen-induced acute kidney injury partly by regulating SIRT3/SOD2 pathway. [Journal Article]Front Med (Lausanne). 2022; 9:1055252.FM
- CONCLUSIONS: In summary, Fc might reduce renal tubular injury and mitochondrial dysfunction in AKI partly through the regulation of SIRT3/SOD2 pathway.
- PMC Free PDF
- Acetaminophen-Induced Hepatotoxicity in Obesity and Nonalcoholic Fatty Liver Disease: A Critical Review. [Journal Article]Livers. 2023 Mar; 3(1):33-53.L
- The epidemic of obesity, type 2 diabetes and nonalcoholic liver disease (NAFLD) favors drug consumption, which augments the risk of adverse events including liver injury. For more than 30 years, a series of experimental and clinical investigations reported or suggested that the common pain reliever acetaminophen (APAP) could be more hepatotoxic in obesity and related metabolic diseases, at least …
- Publisher Full Text (DOI)
- Fatty liver-mediated glycine restriction impairs glutathione synthesis and causes hypersensitization to acetaminophen. [Preprint]bioRxiv. 2023 Jan 18B
- Non-alcoholic fatty liver disease (NAFLD) affects nearly one third of the population worldwide. Understanding metabolic pathways involved can provide insights into disease progression. Untargeted metabolomics of livers from mice with early-stage steatosis indicated a decrease in methylated metabolites suggesting altered one carbon metabolism. The levels of glycine, a central component of one carb…
- PMC Free PDF
- Does Facial Fracture Management Require Opioids? A Pilot Trial of a Narcotic-Minimizing Analgesia Protocol for Operative Facial Trauma. [Journal Article]J Craniofac Surg. 2023 Jan 30 [Online ahead of print]JC
- Opioid minimization in the acute postoperative phase is timely in the era of the opioid epidemic. The authors hypothesize that patients with facial trauma receiving multimodal, narcotic-minimizing pain management in the perioperative period will consume fewer morphine milligram equivalents (MMEs) while maintaining adequate pain control compared with a traditional analgesia protocol. An IRB-approv…
- Publisher Full Text (DOI)
- Pharmacokinetic and Pharmacodynamic Herb-Drug Interactions of Common Over-the-Counter Pain Medications. [Review]Biomed Chromatogr. 2023 Jan 29 [Online ahead of print]BC
- Pain is one of the most common reasons for seeking medical intervention, and self-medication with over-the-counter medications and/or traditional herbal remedies has become increasingly popular. In this review, original articles on understanding possible herb-drug interaction between traditional herbs and four major pain medication: acetaminophen, aspirin, ibuprofen, and naproxen were compiled an…
- Publisher Full Text (DOI)
- Characterization of childhood exposure to environmental contaminants using stool in a semi-urban middle-class cohort from eastern Canada. [Journal Article]Environ Res. 2023 Jan 25 [Online ahead of print]ER
- Children are exposed to various environmental organic and inorganic contaminants with effects on health outcomes still largely unknown. Many matrices (e.g., blood, urine, nail, hair) have been used to characterize exposure to organic and inorganic contaminants. The sampling of feces presents several advantages; it is non-invasive and provides a direct evaluation of the gut microbiome exposure to …
- Publisher Full Text (DOI)
- Mera: A scalable high throughput automated micro-physiological system. [Journal Article]SLAS Technol. 2023 Jan 25 [Online ahead of print]ST
- There is an urgent need for scalable Microphysiological Systems (MPS's)1 that can better predict drug efficacy and toxicity at the preclinical screening stage. Here we present Mera, an automated, modular and scalable system for culturing and assaying microtissues with interconnected fluidics, inbuilt environmental control and automated image capture. The system presented has multiple possible flu…
- Publisher Full Text (DOI)
- Self-assembled FGF21 nanoparticles alleviate drug-induced acute liver injury. [Journal Article]
- Acetaminophen (N-acetyl-p-aminophenol, APAP) is a common antipyretic agent and analgesic. An overdose of APAP can result in acute liver injury (ALI). Oxidative stress and inflammation are central to liver injury. N-acetylcysteine (NAC), a precursor of glutathione, is used commonly in clinical settings. However, the window of NAC treatment is limited, and more efficacious alternatives must be foun…
- PMC Free PDF
- Is Paracetamol Better than Diclofenac Sodium in Management of Postoperative Pain and Edema Following Major Maxillofacial Surgeries? [Journal Article]
- Paracetamol is an optimal non-opioid analgesic and holds considerable advantages over NSAIDs in managing post-operative pain. Literature to date doesn't provide substantial documentation of it's efficacy and safety in major oral and maxillofacial surgeries. The study is designed to compare the effectiveness of intravenous paracetamol with diclofenac sodium for controlling post-operative pain and …
- Publisher Full Text (DOI)
- Internuclear distance measurements between 1H and 14N in multi-component rigid solids at fast MAS. [Journal Article]J Magn Reson. 2023 Jan 18; 348:107378.JM
- 1H-14N internuclear distances are readily and accurately measured using the symmetry-based phase-modulated resonance-echo saturation-pulse double-resonance (PM-S-RESPDOR) method in rigid solids. The fraction curve, (S0 - S')/S0, is represented by a single variable of a 1H-14N heteronuclear dipolar coupling, where S0 and S' are the PM-S-RESPDOR signal intensity with and without 14N PM saturation p…
- Publisher Full Text (DOI)
- Caveolin-1 ameliorates acetaminophen-aggravated inflammatory damage and lipid deposition in non-alcoholic fatty liver disease via the ROS/TXNIP/NLRP3 pathway. [Journal Article]Int Immunopharmacol. 2023 Jan; 114:109558.II
- The overuse of acetaminophen (APAP) may cause more severe hepatotoxicity in patients with non-alcoholic fatty liver disease (NAFLD). Caveolin-1 (CAV1), is an essential regulator of metabolic function, which can alleviate liver damage by scavenging reactive oxygen species (ROS). Evidence suggests that the NOD-like receptor family pyrin domain-containing 3 (NLRP3) -mediated pyroptosis is involved i…
- Publisher Full Text (DOI)
- Reducing Opioid Overprescribing through Procedure-specific Prescribing Guidelines. [Journal Article]Plast Reconstr Surg Glob Open. 2023 Jan; 11(1):e4776.PR
- CONCLUSIONS: A procedure-specific prescribing model is a straight-forward intervention to promote safer opioid-prescribing practices in plastic surgery. Its usage in clinical practice may lead to more appropriate opioid prescribing.
- PMC Free PDF
- Analgesia in Postoperative Adult Strabismus Patients. [Journal Article]J Pediatr Ophthalmol Strabismus. 2023 Jan-Feb; 60(1):e5-e7.JP
- This survey of pediatric ophthalmic surgeons on analgesia for postoperative adult strabismus patients indicates that 65% prescribed acetaminophen and/or nonsteroidal anti-inflammatory drugs (NSAIDs), and 12% to 16% prescribed opioids. Most surgeons reported reasonable control of pain regardless of analgesia. Acetaminophen and/or NSAIDs may adequately control pain, although certain circumstances m…
- Publisher Full Text (DOI)
- Migraine treatment in pregnancy: A survey of comfort and treatment practices of women's healthcare providers. [Journal Article]Headache. 2023 Jan 25 [Online ahead of print]H
- CONCLUSIONS: This survey of women's healthcare providers revealed varying levels of comfort regarding migraine management during pregnancy, and highlights the need for additional education regarding migraine treatment safety data during pregnancy.
- Publisher Full Text (DOI)
- Pharmaceutical toxicity is a common pattern of inpatient acute poisonings in Birjand City, East of Iran. [Journal Article]
- Information on the pattern of acute poisonings in hospitals of Birjand city, Iran, is limited. This study aimed to address this knowledge gap by examining the admissions in a major poisoning center in eastern Iran. This cross-sectional study included patients admitted to the Imam Reza Hospital in Birjand over 12 months. Medical records of the poisoned patients were reviewed, and the study variabl…
- PMC Free PDF
- eAn effective and stability-indicating method development and optimization utilizing the Box-Behnken Design for the simultaneous determination of Acetaminophen, Caffeine, and Aspirin in Tablets Formulation. [Journal Article]Biomed Chromatogr. 2023 Jan 24 [Online ahead of print]BC
- Analytical techniques must be sensitive, specific, and accurate in order to assess the active pharmaceutical ingredients in pharmaceutical dosage forms. The Quality by Design (QbD) application has proven to be a practical method for magnifying HPLC operations. This article discusses the successfully developed QbD-based stability-indicative LC method for evaluating acetaminophen, caffeine, and asp…
- Publisher Full Text (DOI)
- Oral NSAIDs vs. Other Oral Analgesic Agents for Acute Soft Tissue Injury. [Journal Article]Am Fam Physician. 2023 Jan; 107(1):23-24.AF
- Retracted: Comparison between Ibuprofen and Acetaminophen in the Treatment of Infectious Fever in Children: A Meta-Analysis. [Retraction of Publication]
- [This retracts the article DOI: 10.1155/2022/1794258.].
- PMC Free PDF
- Recombinant GM-CSF for diseases of GM-CSF insufficiency: Correcting dysfunctional mononuclear phagocyte disorders. [Review]
- Endogenous granulocyte-macrophage colony-stimulating factor (GM-CSF), identified by its ability to support differentiation of hematopoietic cells into several types of myeloid cells, is now known to support maturation and maintain the metabolic capacity of mononuclear phagocytes including monocytes, macrophages, and dendritic cells. These cells sense and attack potential pathogens, present antige…
- PMC Free PDF
- Dextromethorphan improves locomotor activity and decreases brain oxidative stress and inflammation in an animal model of acute liver failure. [Journal Article]
- CONCLUSIONS: The effect of dextromethorphan on oxidative stress and inflammation seems to be a major mechanism for its neuroprotective properties in HE. Based on these data DXM could be applied as an effective pharmacological option against HE-associated brain injury.
- PMC Free PDF
- A novel humanized Chi3l1 blocking antibody attenuates acetaminophen-induced liver injury in mice. [Journal Article]
- Acetaminophen (APAP) overdose is a leading cause of acute liver injury in the USA. The chitinase 3-like-1 (Chi3l1) protein contributes to APAP-induced liver injury (AILI) by promoting hepatic platelet recruitment. Here, we report the development of a Chi3l1-targeting antibody as a potential therapy for AILI. By immunizing a rabbit successively with the human and mouse Chi3l1 proteins, we isolated…
- PMC Free PDF
- Continuous operation of fungal wheel reactor based on solid-state fermentation for the removal of pharmaceutical and personal care products. [Journal Article]J Environ Manage. 2023 Jan 20; 331:117316.JE
- Wood-rotting fungi and their enzymatic systems represent promising biocatalysts for the removal of pharmaceuticals and personal care products (PPCPs) from wastewater. We designed a fungal wheel reactor (FWR) based on solid-state fermentation (SSF) of Trametes versicolor and a lignocellulosic substrate, which was used as an immobilization carrier for fungal biomass and the sole initial nutrient so…
- Publisher Full Text (DOI)
- Intravenous Hydromorphone Versus Intravenous Acetaminophen for Older Adult Patients: More to Think About. [Letter]Ann Emerg Med. 2023 Feb; 81(2):246-247.AE
- Publisher Full Text (DOI)
- Development of a newly designed biosensor using multi-walled carbon nanotubes (MWCNTs) with gold nanoparticles (AuNPs) in the presence of acetaminophen for detection of Escherichia coli. [Journal Article]Arch Microbiol. 2023 Jan 21; 205(2):70.AM
- Escherichia coli is one of the main indicators in the quality control of water, pharmaceuticals, and other samples. Compared with the time-consuming and high prices of the classical methods, with their high risks in the case of insensitive, contamination and offline detections, biosensors have long been a fast and accurate approach for identifying different bacteria. The present study reports the…
- Publisher Full Text (DOI)
- The Opioid Analgesic Reduction Study (OARS) Pilot: A Double-Blind Randomized Multicenter Trial. [Journal Article]JDR Clin Trans Res. 2023 Jan 20 [Online ahead of print]JC
- With addiction rates and opioid deaths increasing, health care providers are obligated to help stem the opioid crisis. As limited studies examine the comparative effectiveness of fixed-dose combination nonopioid analgesia to opioid-containing analgesia, a comparative effectiveness study was planned and refined by conducting a pilot study.
- Publisher Full Text (DOI)
- Drug Metabolism of Hepatocyte-like Organoids and Their Applicability in In Vitro Toxicity Testing. [Journal Article]
- Emerging advances in the field of in vitro toxicity testing attempt to meet the need for reliable human-based safety assessment in drug development. Intrahepatic cholangiocyte organoids (ICOs) are described as a donor-derived in vitro model for disease modelling and regenerative medicine. Here, we explored the potential of hepatocyte-like ICOs (HL-ICOs) in in vitro toxicity testing by exploring t…
- PMC Free PDF
- Molecular Oxygen Activation by Citric Acid Boosted Pyrite-Photo-Fenton Process for Degradation of PPCPs in Water. [Journal Article]
- Pyrite has been used in photo-Fenton reactions for the degradation of pollutants, but the application of photo-Fenton processes with extra H2O2 in real water/wastewater treatment has still been limited by the economic cost of H2O2 and artificial light sources. Herein, citric acid (CA) and simulated/natural sunlight are used to develop a pyrite-based photo-Fenton system (pyrite-CA-light) in situ g…
- PMC Free PDF
- Treatment of Drug-Induced Liver Injury. [Review]
- Current pharmacotherapy options of drug-induced liver injury (DILI) remain under discussion and are now evaluated in this analysis. Needless to say, the use of the offending drug must be stopped as soon as DILI is suspected. Normal dosed drugs may cause idiosyncratic DILI, and drugs taken in overdose commonly lead to intrinsic DILI. Empirically used but not substantiated regarding efficiency by r…
- PMC Free PDF
- Adipose-Derived Mesenchymal Stem Cells Inhibit JNK-Mediated Mitochondrial Retrograde Pathway to Alleviate Acetaminophen-Induced Liver Injury. [Journal Article]
- Acetaminophen (APAP) is the major cause of drug-induced liver injury, with limited treatment options. APAP overdose invokes excessive oxidative stress that triggers mitochondria-to-nucleus retrograde pathways, contributing to APAP-induced liver injury (AILI). Mesenchymal stem cell therapy is a promising tool for acute liver failure. Therefore, the purpose of this study was to investigate the bene…
- PMC Free PDF
- The molecular mechanisms of acetaminophen-induced hepatotoxicity and its potential therapeutic targets. [Review]Exp Biol Med (Maywood). 2023 Jan 20 [Online ahead of print]EB
- Acetaminophen (APAP), a widely used antipyretic and analgesic drug in clinics, is relatively safe at therapeutic doses; however, APAP overdose may lead to fatal acute liver injury. Currently, N-acetylcysteine (NAC) is clinically used as the main antidote for APAP poisoning, but its therapeutic effect remains limited owing to rapid disease progression and the general diagnosis of advanced poisonin…
- Publisher Full Text (DOI)