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28,104 results
  • Acetaminophen-Induced Hepatotoxicity in Obesity and Nonalcoholic Fatty Liver Disease: A Critical Review. [Journal Article]
    Livers. 2023 Mar; 3(1):33-53.Begriche K, Penhoat C, … Fromenty B
  • The epidemic of obesity, type 2 diabetes and nonalcoholic liver disease (NAFLD) favors drug consumption, which augments the risk of adverse events including liver injury. For more than 30 years, a series of experimental and clinical investigations reported or suggested that the common pain reliever acetaminophen (APAP) could be more hepatotoxic in obesity and related metabolic diseases, at least …
  • Pharmacokinetic and Pharmacodynamic Herb-Drug Interactions of Common Over-the-Counter Pain Medications. [Review]
    Biomed Chromatogr. 2023 Jan 29 [Online ahead of print]Sun CK, Tsai TH
  • Pain is one of the most common reasons for seeking medical intervention, and self-medication with over-the-counter medications and/or traditional herbal remedies has become increasingly popular. In this review, original articles on understanding possible herb-drug interaction between traditional herbs and four major pain medication: acetaminophen, aspirin, ibuprofen, and naproxen were compiled an…
  • Mera: A scalable high throughput automated micro-physiological system. [Journal Article]
    SLAS Technol. 2023 Jan 25 [Online ahead of print]Cliffe FE, Madden C, … Lyons M
  • There is an urgent need for scalable Microphysiological Systems (MPS's)1 that can better predict drug efficacy and toxicity at the preclinical screening stage. Here we present Mera, an automated, modular and scalable system for culturing and assaying microtissues with interconnected fluidics, inbuilt environmental control and automated image capture. The system presented has multiple possible flu…
  • Self-assembled FGF21 nanoparticles alleviate drug-induced acute liver injury. [Journal Article]
    Front Pharmacol. 2022; 13:1084799.Huang Z, Wang H, … Zhao Y
  • Acetaminophen (N-acetyl-p-aminophenol, APAP) is a common antipyretic agent and analgesic. An overdose of APAP can result in acute liver injury (ALI). Oxidative stress and inflammation are central to liver injury. N-acetylcysteine (NAC), a precursor of glutathione, is used commonly in clinical settings. However, the window of NAC treatment is limited, and more efficacious alternatives must be foun…
  • Internuclear distance measurements between 1H and 14N in multi-component rigid solids at fast MAS. [Journal Article]
    J Magn Reson. 2023 Jan 18; 348:107378.Ogaeri Y, Suzuki N, … Nishiyama Y
  • 1H-14N internuclear distances are readily and accurately measured using the symmetry-based phase-modulated resonance-echo saturation-pulse double-resonance (PM-S-RESPDOR) method in rigid solids. The fraction curve, (S0 - S')/S0, is represented by a single variable of a 1H-14N heteronuclear dipolar coupling, where S0 and S' are the PM-S-RESPDOR signal intensity with and without 14N PM saturation p…
  • Analgesia in Postoperative Adult Strabismus Patients. [Journal Article]
    J Pediatr Ophthalmol Strabismus. 2023 Jan-Feb; 60(1):e5-e7.Rho J, Gannon E, … Hoehn ME
  • This survey of pediatric ophthalmic surgeons on analgesia for postoperative adult strabismus patients indicates that 65% prescribed acetaminophen and/or nonsteroidal anti-inflammatory drugs (NSAIDs), and 12% to 16% prescribed opioids. Most surgeons reported reasonable control of pain regardless of analgesia. Acetaminophen and/or NSAIDs may adequately control pain, although certain circumstances m…
  • The Opioid Analgesic Reduction Study (OARS) Pilot: A Double-Blind Randomized Multicenter Trial. [Journal Article]
    JDR Clin Trans Res. 2023 Jan 20 [Online ahead of print]Feldman CA, Fredericks-Younger J, … Lu SE
  • With addiction rates and opioid deaths increasing, health care providers are obligated to help stem the opioid crisis. As limited studies examine the comparative effectiveness of fixed-dose combination nonopioid analgesia to opioid-containing analgesia, a comparative effectiveness study was planned and refined by conducting a pilot study.
  • Treatment of Drug-Induced Liver Injury. [Review]
    Biomedicines. 2022 Dec 21; 11(1)Teschke R
  • Current pharmacotherapy options of drug-induced liver injury (DILI) remain under discussion and are now evaluated in this analysis. Needless to say, the use of the offending drug must be stopped as soon as DILI is suspected. Normal dosed drugs may cause idiosyncratic DILI, and drugs taken in overdose commonly lead to intrinsic DILI. Empirically used but not substantiated regarding efficiency by r…
  • The molecular mechanisms of acetaminophen-induced hepatotoxicity and its potential therapeutic targets. [Review]
    Exp Biol Med (Maywood). 2023 Jan 20 [Online ahead of print]Luo G, Huang L, Zhang Z
  • Acetaminophen (APAP), a widely used antipyretic and analgesic drug in clinics, is relatively safe at therapeutic doses; however, APAP overdose may lead to fatal acute liver injury. Currently, N-acetylcysteine (NAC) is clinically used as the main antidote for APAP poisoning, but its therapeutic effect remains limited owing to rapid disease progression and the general diagnosis of advanced poisonin…
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