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4,262 results
  • Pharmacological Treatment of Bipolar Depression: What are the Current and Emerging Options? [Journal Article]
    Neuropsychiatr Dis Treat. 2020; 16:1459-1472.Yalin N, Young AH
  • Depression accounts for the predominant burden associated with bipolar disorder. The identification and management of bipolar depression are challenging, since bipolar depression differs from unipolar depression, responding poorly to traditional antidepressants, which may also induce a switch to hypomania/mania, mixed states and/or cause rapid cycling. Current treatment options for bipolar depres…
  • Variability in Price of Generic Antipsychotic Medications at Community Pharmacies. [Journal Article]
    Psychiatr Serv. 2020 Jun 24 [Online ahead of print]Kriz CR, Nelson LA, … Sommi RW
  • CONCLUSIONS: This report is the first on pharmacy-level variability in the costs of generic antipsychotic treatment options for schizophrenia. Appreciable differences were found in the costs of generic antipsychotics. Understanding variability in antipsychotic pricing may be important for providers serving uninsured patients.
  • Aripiprazole cytotoxicity coincides with activation of the unfolded protein response in human hepatic cells. [Journal Article]
    J Pharmacol Exp Ther. 2020 Jun 17 [Online ahead of print]Forno F, Maatuf Y, … Tirosh B
  • Schizophrenia is a mental disease that results in decreased life expectancy and wellbeing, by promoting obesity and sedentary lifestyles. Schizophrenia is treated by antipsychotic drugs. While the second generation of antipsychotics (SGA), Olanzapine and Aripiprazole are more effective in treating schizophrenia, they display a higher risk of metabolic side effects, mostly by development of diabet…
  • Low-dose Aripiprazole Induced Enuresis Continuum in a Child. [Journal Article]
    Clin Neuropharmacol. 2020 Jun 11 [Online ahead of print]Karatoprak S, Uzun N
  • Aripiprazole is an atypical antipsychotic commonly used in the treatment of childhood disorders, such as bipolar disorder, psychosis, and irritability associated with autism spectrum disorder. Common side effects of its use include extrapyramidal side effects, somnolence, tremor, fatigue, nausea, and akathisia. Enuresis is an additional and rare side effect of aripiprazole use. There is limited d…
  • Pharmacological Treatments for Patients with Treatment-Resistant Depression. [Review]
    Pharmaceuticals (Basel). 2020 Jun 04; 13(6)Ruberto VL, Jha MK, Murrough JW
  • Over a third of patients with major depressive disorder (MDD) do not have an adequate response to first-line antidepressant treatments, i.e., they have treatment-resistant depression (TRD). These patients tend to have a more severe course of illness and are at an increased risk of suicide. Next step treatment options for patients with TRD, include switching to a different antidepressant, combinin…
  • Effects of Oxidation of Human Serum Albumin on the Binding of Aripiprazole. [Journal Article]
    Biol Pharm Bull. 2020; 43(6):1023-1026.Sakurama K, Nishi K, … Otagiri M
  • Aripiprazole (ARP) is one of antipsychotics and binds to human serum albumin (HSA) with a high affinity. In this study, we investigated the binding characteristics of ARP to oxidized HSA as observed in chronic disease conditions. Oxidized HSAs were prepared using chloramine-T (CT-HSA) or metal-catalyzed oxidation system (MCO-HSA) in vitro, respectively. An increase in the carbonyl content was con…
  • Comparative cardiometabolic risk of antipsychotics in children, adolescents and young adults. [Journal Article]
    Eur Child Adolesc Psychiatry. 2020 May 29 [Online ahead of print]Chung YS, Shao SC, … Lai EC
  • Understanding different cardiometabolic safety profiles of antipsychotics helps avoid unintended outcomes among young patients. We conducted a population-based study to compare cardiometabolic risk among different antipsychotics in children, adolescents and young adults. From Taiwan's National Health Insurance Database, 2001-2013, we identified two patient cohorts aged 5-18 (children and adolesce…
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