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34,750 results
  • Modeling adaptation of sorghum in Ethiopia with APSIM-opportunities with G×E×M. [Journal Article]
    Agron Sustain Dev. 2023; 43(1):15.Tirfessa A, Getachew F, … Hammer G
  • Sorghum is an important food and feed crop in the dry lowland areas of Ethiopia. Farmers grow both early-sown long-duration landraces and late-sown short-duration improved varieties. Because timing and intensity of drought stress can vary in space and time, an understanding of major traits (G), environments (E), management (M), and their interactions (G×E×M) is needed to optimize grain and forage…
  • Genetic liability to major psychiatric disorders contributes to multi-faceted quality of life outcomes in children and adults. [Preprint]
    medRxiv. 2023 Jan 18Shi Y, Franke B, … Sprooten E
  • CONCLUSIONS: The present study reveals an inverse relationship between psychiatric genetic liabilities and multiple quality of life metrics, with ADHD-associated genetic risk being the main contributor in both children and adults, and MDD additionally showing effects in adults. All effect sizes observed were small, as expected. Understanding potential real-world outcomes of quantitative measures of disorder-related genetic risks in the general population can provide a scientific foundation for societal intervention and policy-making processes, with profound implications for promoting a flourishing society.
  • A novel head-fixed assay for social touch in mice uncovers aversive responses in two autism models. [Preprint]
    bioRxiv. 2023 Jan 13Chari T, Hernandez A, Portera-Cailliau C
  • Social touch, an important aspect of social interaction and communication, is essential to kinship across animal species. How animals experience and respond to social touch has not been thoroughly investigated, in part due to the lack of appropriate assays. Previous studies that examined social touch in freely moving rodents lacked the necessary temporal and spatial control over individual touch …
  • The autism-associated loss of δ-catenin functions disrupts social behaviors. [Preprint]
    bioRxiv. 2023 Jan 12Mendez-Vazquez H, Roach RL, … Kim S
  • δ-catenin is expressed in excitatory synapses and functions as an anchor for the glutamatergic AMPA receptor (AMPAR) GluA2 subunit in the postsynaptic density. The glycine 34 to serine (G34S) mutation in the δ-catenin gene is found in autism spectrum disorder (ASD) patients and induces loss of δ-catenin functions at excitatory synapses, which is presumed to underlie ASD pathogenesis in humans. Ho…
  • Resting Heart Rate Variability and Emotion Dysregulation in Adolescents with Autism Spectrum Disorder. [Journal Article]
    J Autism Dev Disord. 2023 Jan 30 [Online ahead of print]Chiu HT, Ip IN, … Wong SWH
  • Emotion dysregulation is common among individuals with autism spectrum disorder (ASD). This study examined the relationship between emotion dysregulation and resting heart rate variability (HRV), a marker of the autonomic nervous system, in ASD adolescents. Resting HRV data were collected from ASD (n = 23) and typically developing (TD) adolescents (n = 32) via short-term electrocardiogram. Parent…
  • Evidence for parent-of-origin effects in autism spectrum disorder: a narrative review. [Review]
    J Appl Genet. 2023 Jan 30 [Online ahead of print]Ryan NM, Heron EA
  • Autism spectrum disorder (ASD) is a heterogeneous group of early-onset neurodevelopmental disorders known to be highly heritable with a complex genetic architecture. Abnormal brain developmental trajectories that impact synaptic functioning, excitation-inhibition balance and brain connectivity are now understood to play a central role in ASD. Ongoing efforts to identify the genetic underpinnings …
  • DeepMNF: Deep Multimodal Neuroimaging Framework for Diagnosing Autism Spectrum Disorder. [Journal Article]
    Artif Intell Med. 2023 Feb; 136:102475.Abbas SQ, Chi L, Chen YP
  • The growing prevalence of neurological disorders, e.g., Autism Spectrum Disorder (ASD), demands robust computer-aided diagnosis (CAD) due to the diverse symptoms which require early intervention, particularly in young children. The absence of a benchmark neuroimaging diagnostics paves the way to study transitions in the brain's anatomical structure and neurological patterns associated with ASD. T…
  • Anatomy of the miniature four-legged mite Achaetocoptes quercifolii (Arachnida: Acariformes: Eriophyoidea). [Journal Article]
    Arthropod Struct Dev. 2023 Jan 26; 72:101235.Propistsova EA, Makarova AA, … Polilov AA
  • Miniaturization is one of the important trends in the evolution of terrestrial arthropods. In order to study adaptations to microscopic sizes, the anatomy of the smallest insects was previously studied, but not the anatomy of the smallest mites. Some of the smallest mites are Eriophyidae. In this study we describe for the first time the anatomy of the mite Achaetocoptes quercifolii, which is abou…
  • Autism spectrum disorder and personality disorders: How do clinicians carry out a differential diagnosis? [Journal Article]
    Autism. 2023 Jan 28 [Online ahead of print]Allely CS, Woodhouse E, Mukherjee RA
  • It is now recognised that autism spectrum disorder (ASD) and personality disorders (PDs) have a variety of factors in common. However, the exact nature of the relationship between ASD and the PDs remains unclear. The overlapping symptom profiles of ASD and PDs can lead to diagnostic uncertainty - features of ASD and PD can be misattributed and easily lead to misdiagnosis of ASD patients. Since di…
  • Evaluation of Chronic Constipation in Children With Autism Spectrum Disorder. [Journal Article]
    J Pediatr Gastroenterol Nutr. 2023 Feb 01; 76(2):154-159.Coe A, Ciricillo J, … Williams KC
  • CONCLUSIONS: Chronic constipation does not appear to be associated with a higher rate of abnormal colonic motility in children with ASD. Clinical information of disease duration and presence of soiling due to constipation show promise in identifying patients with ASD at a greater risk for abnormal colonic motility.
  • Factors predicting current and future use of video-modelling in teaching students with autism spectrum disorder (ASD): a Saudi Arabian perspective. [Journal Article]
    Disabil Rehabil Assist Technol. 2023 Jan 26 [Online ahead of print]Aldabas R, Alhossein A
  • CONCLUSIONS: Results show that video-modelling is still used as an assistive technology slightly in teaching students with ASD, suggesting that educators may find it challenging to use video-modelling in classrooms. Results indicate that using video-modelling in teaching students with ASD can be influenced by a variety of factors related to the Diffusion of Innovation Theory. This is evidence that educational and rehabilitation stakeholders need to cooperate in addressing these factors to close the research-practice gap, and improve the adoption of video-modelling in classrooms.IMPLICATIONS FOR REHABILITATIONFew studies have addressed how video-modelling as an assistive technology is being adopted in the classroom.The findings revealed that video-modelling was underutilized in the classrooms for students with ASD, indicating the need to investigate causes contributing to this lack of adoption and to increase video-modelling use.Perceived relative advantage, complexity, trialability, and observability predicted educators' current video-modelling use.Perceived relative advantage and trialability predicted educators' future video-modelling use.Support should be done via collaboration among special educators and other professionals (e.g., assistive technology specialists, occupational and physical therapists) to help in development of and use video-modelling more extensively.
  • Adaptive noise depression for functional brain network estimation. [Journal Article]
    Front Psychiatry. 2022; 13:1100266.Ma D, Peng L, Gao X
  • Autism spectrum disorder (ASD) is one common psychiatric illness that manifests in neurological and developmental disorders, which can last throughout a person's life and cause challenges in social interaction, communication, and behavior. Since the standard ASD diagnosis is highly based on the symptoms of the disease, it is difficult to make an early diagnosis to take the best cure opportunity. …
  • GRIN2B-related neurodevelopmental disorder: current understanding of pathophysiological mechanisms. [Review]
    Front Synaptic Neurosci. 2022; 14:1090865.Sabo SL, Lahr JM, … Sceniak MP
  • The GRIN2B-related neurodevelopmental disorder is a rare disease caused by mutations in the GRIN2B gene, which encodes the GluN2B subunit of NMDA receptors. Most individuals with GRIN2B-related neurodevelopmental disorder present with intellectual disability and developmental delay. Motor impairments, autism spectrum disorder, and epilepsy are also common. A large number of pathogenic de novo mut…
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