- Modeling adaptation of sorghum in Ethiopia with APSIM-opportunities with G×E×M. [Journal Article]Agron Sustain Dev. 2023; 43(1):15.AS
- Sorghum is an important food and feed crop in the dry lowland areas of Ethiopia. Farmers grow both early-sown long-duration landraces and late-sown short-duration improved varieties. Because timing and intensity of drought stress can vary in space and time, an understanding of major traits (G), environments (E), management (M), and their interactions (G×E×M) is needed to optimize grain and forage…
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- The Association between Threatened Abortion and the Risk of Autism Spectrum Disorders among Children: A Meta-Analysis. [Review]Biomed Res Int. 2023; 2023:5249585.BR
- CONCLUSIONS: The findings suggest that threatened abortion is a risk factor for ASD. As a result, screening tools to detect are necessary in mothers facing a threatened abortion.
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- Intestinal metabolites and the risk of autistic spectrum disorder: A two-sample Mendelian randomization study. [Journal Article]Front Psychiatry. 2022; 13:1034214.FP
- CONCLUSIONS: Our study found potential causality from intestinal metabolites on ASD. Clinicians are encouraged to offer preventive measures to such populations.
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- Will the adjustment of insertional pedicle screw positions affect the risk of adjacent segment diseases biomechanically? An in-silico study. [Journal Article]Front Surg. 2022; 9:1004642.FS
- CONCLUSIONS: Reducing the fixation stiffness by adjusting the insertional screw positions could alleviate the biomechanical deterioration and be an effective method to reduce the risk of ASD caused by BPS.
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- Editorial: Dietary polyphenols, gut microbiota, and human health. [Editorial]Front Pharmacol. 2022; 13:1131074.FP
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- TCF4 mutations disrupt synaptic function through dysregulation of RIMBP2 in patient-derived cortical neurons. [Preprint]bioRxiv. 2023 Jan 20B
- Genetic variation in the transcription factor 4 ( TCF4) gene is associated with risk for a variety of developmental and psychiatric conditions, which includes a syndromic form of ASD called Pitt Hopkins Syndrome (PTHS). TCF4 encodes an activity-dependent transcription factor that is highly expressed during cortical development and in animal models is shown to regulate various aspects of neuronal …
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- Genetic liability to major psychiatric disorders contributes to multi-faceted quality of life outcomes in children and adults. [Preprint]medRxiv. 2023 Jan 18M
- CONCLUSIONS: The present study reveals an inverse relationship between psychiatric genetic liabilities and multiple quality of life metrics, with ADHD-associated genetic risk being the main contributor in both children and adults, and MDD additionally showing effects in adults. All effect sizes observed were small, as expected. Understanding potential real-world outcomes of quantitative measures of disorder-related genetic risks in the general population can provide a scientific foundation for societal intervention and policy-making processes, with profound implications for promoting a flourishing society.
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- A novel head-fixed assay for social touch in mice uncovers aversive responses in two autism models. [Preprint]bioRxiv. 2023 Jan 13B
- Social touch, an important aspect of social interaction and communication, is essential to kinship across animal species. How animals experience and respond to social touch has not been thoroughly investigated, in part due to the lack of appropriate assays. Previous studies that examined social touch in freely moving rodents lacked the necessary temporal and spatial control over individual touch …
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- The autism-associated loss of δ-catenin functions disrupts social behaviors. [Preprint]bioRxiv. 2023 Jan 12B
- δ-catenin is expressed in excitatory synapses and functions as an anchor for the glutamatergic AMPA receptor (AMPAR) GluA2 subunit in the postsynaptic density. The glycine 34 to serine (G34S) mutation in the δ-catenin gene is found in autism spectrum disorder (ASD) patients and induces loss of δ-catenin functions at excitatory synapses, which is presumed to underlie ASD pathogenesis in humans. Ho…
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- Vigilance or avoidance: How do autistic traits and social anxiety modulate attention to the eyes? [Journal Article]Front Neurosci. 2022; 16:1081769.FN
- Social anxiety disorder (SAD) and autism spectrum disorder (ASD) are highly overlapping in symptoms and have a high rate of comorbidity, posing challenges in diagnosis and intervention for both disorders. Both disorders are linked to abnormal attention to the eyes, yet how they interactively modulate the attentional process to the eyes remains unclear.
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- An auditory processing advantage enables communication in less complex social settings: Signs of an extreme female brain in children and adolescents being assessed for Autism Spectrum Disorders. [Journal Article]Front Psychol. 2022; 13:1068001.FP
- CONCLUSIONS: A female unisensory processing advantage in ASD could very well be explaining the male domination in ASD. However, the social difficulties related to multisensory processing indicate that ASD females might be struggling as hard as males in more complex settings. Implications on the assessment procedure are discussed.
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- Resting Heart Rate Variability and Emotion Dysregulation in Adolescents with Autism Spectrum Disorder. [Journal Article]J Autism Dev Disord. 2023 Jan 30 [Online ahead of print]JA
- Emotion dysregulation is common among individuals with autism spectrum disorder (ASD). This study examined the relationship between emotion dysregulation and resting heart rate variability (HRV), a marker of the autonomic nervous system, in ASD adolescents. Resting HRV data were collected from ASD (n = 23) and typically developing (TD) adolescents (n = 32) via short-term electrocardiogram. Parent…
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- Evidence for parent-of-origin effects in autism spectrum disorder: a narrative review. [Review]J Appl Genet. 2023 Jan 30 [Online ahead of print]JA
- Autism spectrum disorder (ASD) is a heterogeneous group of early-onset neurodevelopmental disorders known to be highly heritable with a complex genetic architecture. Abnormal brain developmental trajectories that impact synaptic functioning, excitation-inhibition balance and brain connectivity are now understood to play a central role in ASD. Ongoing efforts to identify the genetic underpinnings …
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- DeepMNF: Deep Multimodal Neuroimaging Framework for Diagnosing Autism Spectrum Disorder. [Journal Article]Artif Intell Med. 2023 Feb; 136:102475.AI
- The growing prevalence of neurological disorders, e.g., Autism Spectrum Disorder (ASD), demands robust computer-aided diagnosis (CAD) due to the diverse symptoms which require early intervention, particularly in young children. The absence of a benchmark neuroimaging diagnostics paves the way to study transitions in the brain's anatomical structure and neurological patterns associated with ASD. T…
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- MicroRNA-218 regulates neuronal radial migration and morphogenesis by targeting Satb2 in developing neocortex. [Journal Article]Biochem Biophys Res Commun. 2023 Jan 23; 647:9-15.BB
- Neuronal migration and morphogenesis are fundamental processes for cortical development. Their defects may cause abnormities in neural circuit formation and even neuropsychiatric disorders. Many proteins, especially layer-specific transcription factors and adhesion molecules, have been reported to regulate the processes. However, the involvement of non-coding RNAs in cortical development has not …
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- Comparative morphology and ultrastructure of the labial gland among castes of Camponotus japonicus (Hymenoptera: Formicidae). [Journal Article]Arthropod Struct Dev. 2023 Jan 26; 72:101236.AS
- The labial gland is a major exocrine gland in the thoracic cavity of ants, which is connected to the mouth area and opens at the base of the labium. The labial gland in the various castes and males of Camponotus japonicus were examined using dissection, light microscopy, scanning and transmission electron microscopy. Our findings reveal clear caste differences in the appearance of the labial glan…
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- Anatomy of the miniature four-legged mite Achaetocoptes quercifolii (Arachnida: Acariformes: Eriophyoidea). [Journal Article]Arthropod Struct Dev. 2023 Jan 26; 72:101235.AS
- Miniaturization is one of the important trends in the evolution of terrestrial arthropods. In order to study adaptations to microscopic sizes, the anatomy of the smallest insects was previously studied, but not the anatomy of the smallest mites. Some of the smallest mites are Eriophyidae. In this study we describe for the first time the anatomy of the mite Achaetocoptes quercifolii, which is abou…
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- Ultrastructure of the dorsal ocellus of Bittacus planus larvae (Mecoptera: Bittacidae) with evolutionary significance. [Journal Article]Arthropod Struct Dev. 2023 Jan 26; 72:101234.AS
- The Bittacidae are unique in holometabolous insects in that their larvae bear a dorsal ocellus on the frons. The fine structure of the dorsal ocellus, however, has not been investigated to date. Here, the ultrastructure of the larval dorsal ocellus was studied in the hangingfly Bittacus planus Cheng, 1949 using light, scanning, and transmission electron microscopy. The dorsal ocellus of the larva…
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- Autistic traits of children born very preterm assessed using Autism Diagnostic Observation Schedule, Second Edition. [Journal Article]Early Hum Dev. 2023 Jan 25; 176:105716.EH
- Preterm birth has been linked with increased incidence of autism spectrum disorder (ASD). Despite the remarkable difference in the clinical backgrounds between ASD children born preterm and term, cross-sectional studies have found no striking difference in their autistic traits. To highlight autistic traits related with preterm birth, children born very preterm (prospective birth cohort, n = 50) …
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- Autism spectrum disorder and personality disorders: How do clinicians carry out a differential diagnosis? [Journal Article]Autism. 2023 Jan 28 [Online ahead of print]A
- It is now recognised that autism spectrum disorder (ASD) and personality disorders (PDs) have a variety of factors in common. However, the exact nature of the relationship between ASD and the PDs remains unclear. The overlapping symptom profiles of ASD and PDs can lead to diagnostic uncertainty - features of ASD and PD can be misattributed and easily lead to misdiagnosis of ASD patients. Since di…
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- Nutritional status and eating behavior of children with autism spectrum disorders in Vietnam: A case-control study. [Journal Article]Nutr Health. 2023 Jan 27 [Online ahead of print]NH
- Background: Atypical eating behaviors and feeding issues are common in children with autism spectrum disorder (ASD). Aim: This study aims to evaluate the nutritional status and eating behavior of the ASD and typically developing groups. Methods: A case-control study was conducted from January to April 2019 in Nghe An, Vietnam. A total of 93 children in each group participated in the study with th…
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- The Perspectives of Preservice Kinesiology Students Concerning Autism and Physical Activity: Differences by Adapted Physical Activity Exposure. [Journal Article]J Phys Act Health. 2023 Jan 27 [Online ahead of print]JP
- CONCLUSIONS: Results suggest that APA education and contact with children with disabilities improves self-efficacy, perspectives, and knowledge of PA and motor concerns in children with autism spectrum disorder.
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- Phylogenetic implications based on an ultrastructural study with emphasis on the tracheal system of the compound eyes of three species of nymphalid butterflies. [Journal Article]Arthropod Struct Dev. 2023 Jan 25; 72:101230.AS
- Compound eyes are the prominent visual organs of insects and can provide valuable information for the reconstruction of insect phylogeny. Although the largest butterfly family (Nymphalidae) has been well defined, the infrafamilial phylogenetic relationships remain controversial hitherto. In the present study the ultrastructure of the compound eyes of three nymphalids Neptis beroe, Childrena zenob…
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- Evaluation of Chronic Constipation in Children With Autism Spectrum Disorder. [Journal Article]J Pediatr Gastroenterol Nutr. 2023 Feb 01; 76(2):154-159.JP
- CONCLUSIONS: Chronic constipation does not appear to be associated with a higher rate of abnormal colonic motility in children with ASD. Clinical information of disease duration and presence of soiling due to constipation show promise in identifying patients with ASD at a greater risk for abnormal colonic motility.
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- Factors predicting current and future use of video-modelling in teaching students with autism spectrum disorder (ASD): a Saudi Arabian perspective. [Journal Article]Disabil Rehabil Assist Technol. 2023 Jan 26 [Online ahead of print]DR
- CONCLUSIONS: Results show that video-modelling is still used as an assistive technology slightly in teaching students with ASD, suggesting that educators may find it challenging to use video-modelling in classrooms. Results indicate that using video-modelling in teaching students with ASD can be influenced by a variety of factors related to the Diffusion of Innovation Theory. This is evidence that educational and rehabilitation stakeholders need to cooperate in addressing these factors to close the research-practice gap, and improve the adoption of video-modelling in classrooms.IMPLICATIONS FOR REHABILITATIONFew studies have addressed how video-modelling as an assistive technology is being adopted in the classroom.The findings revealed that video-modelling was underutilized in the classrooms for students with ASD, indicating the need to investigate causes contributing to this lack of adoption and to increase video-modelling use.Perceived relative advantage, complexity, trialability, and observability predicted educators' current video-modelling use.Perceived relative advantage and trialability predicted educators' future video-modelling use.Support should be done via collaboration among special educators and other professionals (e.g., assistive technology specialists, occupational and physical therapists) to help in development of and use video-modelling more extensively.
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- Adaptive noise depression for functional brain network estimation. [Journal Article]
- Autism spectrum disorder (ASD) is one common psychiatric illness that manifests in neurological and developmental disorders, which can last throughout a person's life and cause challenges in social interaction, communication, and behavior. Since the standard ASD diagnosis is highly based on the symptoms of the disease, it is difficult to make an early diagnosis to take the best cure opportunity. …
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- Struggle for recognition, rights, and redistribution: Understanding the identity of parents of children with autism spectrum disorder in China. [Journal Article]
- The number of children diagnosed with autism spectrum disorders (ASD) worldwide has increased rapidly in the past decade and China is no exception. Yet the identity development of Chinese parents of children with ASD is little understood. This study employed an ethics of care perspective to explore the identity of parents of children with ASD as shaped in their social-cultural context in mainland…
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- GRIN2B-related neurodevelopmental disorder: current understanding of pathophysiological mechanisms. [Review]
- The GRIN2B-related neurodevelopmental disorder is a rare disease caused by mutations in the GRIN2B gene, which encodes the GluN2B subunit of NMDA receptors. Most individuals with GRIN2B-related neurodevelopmental disorder present with intellectual disability and developmental delay. Motor impairments, autism spectrum disorder, and epilepsy are also common. A large number of pathogenic de novo mut…
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- Feasibility of a Remote-based Nutrition Education and Culinary Skills Program for Young Adults With Autism Spectrum Disorder. [Journal Article]J Nutr Educ Behav. 2023 Jan 24 [Online ahead of print]JN
- CONCLUSIONS: The remote-based nutrition program met feasibility benchmarks for adherence and retention and was well-accepted by participants. A remote-based format for nutrition interventions can reach a wider range of young adults with ASD; however, input from the target population should be considered in the development of the program.
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- Effects of repetitive transcranial magnetic stimulation combined with action-observation-execution on social interaction and communication in autism spectrum disorder: Feasibility study. [Journal Article]Brain Res. 2023 Jan 23; 1804:148258.BR
- CONCLUSIONS: Ten sessions of HF-rTMS combined with AOE could improve both the subitems of communication and daily living skills domain in children aged 7-12 years with ASD. Although it is still inconclusive, this behavioural improvement may be partly attributable to increased cortical activity, as evidenced by beta rhythms.
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